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Faculty and Staff

Biji T. Kurien, PhD
Internal Medicine

Biji T. Kurien, PhD

Professor of Research


OMRF
825 NE 13th St. MS24
Oklahoma City, OK 73104

(405) 271-8000 ext 35204

Biji-Kurien@ouhsc.edu


Academic Section(s):

Endocrinology and Diabetes


Education:

  • 1990     Doctor of Philosophy, Department of Biochemistry, University of Madras, India
  • 1985 - 1990     Doctor of Philosophy, Summa cum laude, Biochemistry, Department of Medical Biochemistry, Post Graduate Institute of Basic Medical Sciences, Taramani, Madras, India
  • 1985 - 1987      Master of Philosophy, Biochemistry, Department of Medical Biochemistry, University of Madras, Madras (Chennai), India
  • 1981 - 1983       Master of Science, Biochemistry, Department of Biochemistry, PSG College of Arts and Science, University of Madras, Coimbatore, India
  • 1978 - 1981       Bachelor of Science, Biochemistry, Biophysics, Zoology, Department of Biochemistry, PSG College of Arts and Science, University of Madras, Coimbatore, India

 


Fellowship:

  • 1992 - 1993       Research Fellow, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK

  • 1989 - 1992       Research Fellow, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK


Clinical/Research Interests:

Research Interests

  • Sjögren’s syndrome
  • Systemic lupus erythematosus
  • Prolidase deficiency
  • Free radical biology
  • Experimental urolithiasis


Select Publications:

Kurien BT, Porter A, Dorri Y, Iqbal S, D'Souza A, Singh A, Asfa S, Cartellieri M, Matsumoto H, Bachmann M, Hensley K, Scofield RH. (2011). Degree of modification of Ro60 by the lipid peroxidation by-product 4-hydroxy-2-nonenal may differentially induce Sjogren syndrome of syndrome or systemic lupus erythematosus in BALB/c mice. Free Radic Biol Med. [Epub ahead of print]

Bippes CC, Feldmann A, Stamova S, Cartellieri M, Schwarzer A, Wehner R, Schmitz M, Rieber EP, Zhao S, Schäkel K, Temme A, Scofield RH, Kurien BT, Bartsch H, Bachmann M. (2011). A novel modular antigen delivery system for immuno targeting of human 6-fulfo LacNac-positive blood dendritic cells (SlanDCs). PLoS One 6:e163152011.

Kurien BT, Dillon SP, Dorri Y, D'Souza A, Scofield RH. (2011). Curcumin does not bind or intercalate into DNA and a noe on the gray side of curcumin. Int J Cancer 128:242-5.

Dorri Y, Kurien BT. (2010). Environmentally safe removal/disposal of Coomassie Brilliant Blue from gel destain and used gel stain. Anal Biochem. 404:193-6.

Kurien BT, D’Souza A, and Scofield RH. (2010). Heat-solubilized curry spice curcumin inhibits antibody-antigen interaction in vitro studies: A possible therapy to alleviate autoimmune disorders. Mol Nutr Food Res. 54:1202-9.

Protein Blotting and Detection: Methods and Protocols. (2009).  Eds. Kurien BT, and Scofield RH. Methods in Molecular Biology Series, Humana Press/Springer Science, New York, NY, Volume 536.

Gomez-Mejiba SE, Zhai Z, Akram H, Pye QN, Hensley K, Kurien BT, Scofield RH, and Ramirez DC. (2009). Inhalation of environmental stressors & chronic inflammation: Autoimmunity and neurodegeneration. Mutat Res 674:62-72.

Dorri Y, Kurien BT, and Scofield RH. (2009). A Simpler and Faster Version of Two-Dimensional Gel Electrophoresis Using Vertical, Mini SDS-PAGE Apparatus. Iran J Chem Chem Eng 2:51-56.

Kurien BT, and Scofield RH. (2009). Increasing aqueous solubility of curcumin for improving bioavailability. Trends Pharmacol Sci 30:334-5.

Kurien BT, and Scofield RH. (2009). Heat solubilized curcumin should be considered in clinical trials for increasing bioavailability. Clin Cancer Res 15:747.

Kurien BT, and Scofield RH. (2009). Bubbling hookah smoke through heat-solubilized curcumin/turmeric and incorporation of the curry spice as an additive or filter in cigarettes to minimize tobacco smoke-related toxicants. Med Hypotheses 73:462-3.

Kurien BT, and Scofield RH. (2008). Sjogren’s Syndrome. Monograph for BMJ Point of Care.

Kurien BT, and Scofield RH. (2008). Lipstick consumption and systemic lupus erythematosus: Nothing to gloss over. Clin Rheumatol 27:1339-40.

Kurien BT, and Scofield RH. (2008). 4-hydroxynonenal modified Ro 60 autoantigen accelerates autoimmunity in experimental animals. Rheumatology (Oxford) 47:1587.

Mathews SA, Kurien BT, and Scofield RH. (2008). Oral manifestations of Sjögren's syndrome. J Dent Res 87:308-18. Review.

Kurien BT. (2008). Name variations can hit citation rankings. Nature 453:450.

Kurien BT, and Scofield RH. (2008). Autoimmunity and oxidatively modified autoantigens. Autoimmun Rev 7:567-73.

D'Souza A, Kurien BT, Rodgers R, Shenoi S, Kurono S, Matsumoto H, Hensley K, Nath S, and Scofield RH. (2008). Detection of catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association as a risk factor in SLE. BMC Med Genet 9:62-69.

Kurien BT. (2007). Reply to 'pH paper trumps expensive kits in measuring acidity'. Nat Med 13:1275.

Kurien BT, Singh A, Matsumoto H, and Scofield RH. (2007). Improving the solubility and pharmacological efficacy of curcumin by heat treatment. Assay Drug Dev Technol 5:567-76.

Kurien BT, Mathews SA, and Scofield RH. (2007). Can low dose diagnostic dental radiation trigger Sjögren's syndrome? Med Hypotheses 69:995-1000.

Kurien BT, and Scofield RH. (2006). Western blotting. Methods 38:283-93.

Kurien BT, Hensley K, Bachmann M, and Scofield RH. (2006). Oxidatively modified autoantigens in autoimmune diseases. Free Rad Biol Med:41:549-56.

Scofield RH, Asfa S, Obeso D, Jonsson R, and Kurien BT. (2005). Immunization with short peptides from the 60-kDa Ro antigen recapitulates the serological and pathological findings as well as the salivary gland dysfunction of Sjögren's syndrome. J Immunol 175:8409-14.

Kurien BT, Gross T, and Scofield RH. (2005). Barbering in mice: a model for trichotillomania. BMJ 331:1503-5.

Kurien BT, Asfa S, Li C, Dorri Y, Jonsson R and Scofield RH. (2005). Induction of Oral Tolerance in Experimental Sjögren's Syndrome Autoimmunity. Scand.J Immunol. 61:418-425.

Scofield RH, Kurien BT, Ganick S, McClain MT, Pye Q, James JA, Schneider RI, Broyles RH, Bachmann M and Hensley K. (2005). Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading. Free Radic Biol Med 38:719-728.