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Balaji Sadhasivam, PhD
Otolaryngology

Balaji Sadhasivam, PhD

Postdoctoral Fellow


Balaji earned his PhD in Endocrinology and Animal Biotechnology from the University of Madras, Chennai, India. His interests are on the impact of modifiable risk factors, such as tobacco use, on cancer risk. His current research focuses on the use of DNA damage and other biological markers as predictors of cancer risk. His ultimate goal is to discover a potential tool that will reduce cancer incidence and mortality by contributing to the early detection and diagnosis of pre-cancerous lesions.


Select Publications:

Recent Publications:

1. Floyd EL, Greenlee S, Oni TM, Sadhasivam B, Queimado L. The Effect of Flow Rate on a Third Generation Sub-Ohm Tank Electronic Nicotine Delivery System - Comparison of CORESTA Flow Rates to More Realistic Flow Rates. Int J Environ Res Public Health, 2021 Jul 15; 18(14):7535. doi: 10.3390/ijerph18147535. PMID: 34299985. PMCID: PMC8307737.

2. Manyanga J, Ganapathy V, Bouharati C, Mehta T, Sadhasivam B, Acharya P, Zhao D, and Queimado L. Electronic cigarette aerosols alter the expression of cisplatin transporters and increase drug resistance in oral cancer cells. Sci Rep. 2021 Jan 19; 11(1):1821. doi: 10.1038/s41598-021-81148-0. PMID: 33469038. PMCID: PMC7815770.

3. Ganapathy V, Manyanga J, Brame L, McGuire D, Sadhasivam B, Floyd E, Rubenstein DA, Ramachandran I, Wagener T, and Queimado L. Electronic cigarette aerosols suppress cellular antioxidant defenses and induce significant oxidative DNA damage. PLoS One. 2017; 12(5):e0177780. doi: 10.1371/journal.pone.0177780. eCollection 2017. PMID: 28542301. PMCID: PMC5436899. 

4. Kumar KM, Aruldhas MM, Banu SL, Sadhasivam B, Vengatesh G, Ganesh KM, Navaneethabalakrishnan S, Navin AK, Michael FM, Venkatachalam S, Stanley JA, Ramachandran I, Banu SK, Akbarsha MA. Male reproductive toxicity of CrVI: In-utero exposure to CrVI at the critical window of testis differentiation represses the expression of Sertoli cell tight junction proteins and hormone receptors in adult F1 progeny rats. Reprod Toxicol. 2017 Apr; 69:84-98. doi: 10.1016/j.reprotox.2017.02.007. Epub 2017 Feb 10. PMID: 28192182.

Selected Conference Presentations:

1. Sadhasivam B, Manyanga J, Ganapathy V, Bouharati C, Mehta T, Mathews B, Castles S, Rubenstein D, Tackett AP, Acharya P, Zhao D, and Queimado L. Cisplatin Resistance In Head And Neck Cancer: Impact Of Secondhand Smoke Exposure. American Head and Neck Society (AHNS) Annual Meeting at COSM 2022, April 27-28, 2022, Dallas, TX. Poster. Awarded the Stephenson Cancer Center Trainee Research Conference and Workshop Travel Award.

2. Sadhasivam B, Manyanga J, Ganapathy V, Bouharati C, Mehta T, Mathews B, Castles S, Rubenstein D, Tackett AP, Acharya P, Zhao D, and Queimado L. Cisplatin Resistance In Head And Neck Cancer: Impact Of Secondhand Smoke Exposure. American Head and Neck Society (AHNS) Annual Meeting at COSM 2022, April 27-28, 2022, Dallas, TX. Research Paper. Received the Robert Maxwell Byers Award for the best clinical research paper submitted to the American Head and Neck Society Annual Meeting at COSM 2022.

3. Sadhasivam B, Manyanga J, Ganapathy V, Bouharati C, Mehta T, Mathews B, Castles S, Rubenstein D,  Tackett AP, Acharya P, Zhao D, and Queimado L. Secondhand Smoke Exposure Alters Drug Transporters and Induces Cisplatin-Resistant in Head and Neck Cancer Cells. 9th Annual Otolaryngology Head and Neck Surgery Research Day, April 2, 2022, OUHSC, Oklahoma City, OK, Oral Presentation. 

4. Brobst D, Ganapathy V, Chissoe G, Sadhasivam B, Chinnaiyan M, Johnson K, and Queimado L. Oral Molecular Changes in Exclusive and Dual Users of Combustible and Electronic Cigarettes. 9th Annual Otolaryngology Head and Neck Surgery Research Day, April 2, 2022, OUHSC, Oklahoma City, OK, Oral Presentation.

5. Chinnaiyan M, Chissoe G, Acharya P, Sadhasivam B, Ganapathy V, Brobst D, Johnson K, Zhao YD, and Queimado L. Marijuana Use And Co-Use Among Tobacco And Non-Tobacco Products Users. 9th Annual Otolaryngology Head and Neck Surgery Research Day, April 2, 2022, OUHSC, Oklahoma City, OK, Oral Presentation.

6. Coles T, Sadhasivam B, Chinnaiyan M, Chissoe G, Ganapathy V, Brobst D, Johnson K, and Queimado L. Evaluation of E-cigarette Mutagenicity in Vapers Using Ames Test. 9th Annual Otolaryngology Head and Neck Surgery Research Day, April 2, 2022, OUHSC, Oklahoma City, OK. Oral Presentation. Won Jesus E. Medina M.D. Award for Excellence in Research by a Medical Student.

7. Milton A, Chinnaiyan M, Chissoe G, Brobst D, Sadhasivam B, Ganapathy V, and Queimado L. Puff Topography Among Single and Dual Users of Combustible Cigarettes, Pod-Based, and Mod-Based Electronic Cigarettes. 9th Annual Otolaryngology Head and Neck Surgery Research Day, April 2, 2022, OUHSC, Oklahoma City, OK. Oral Presentation.

8. Chinnaiyan M, Chissoe G, Acharya P, Sadhasivam B, Ganapathy V, Brobst D, Johnson K, Zhao YD, and Queimado L. Prevalence of marijuana use and co-use among combustible tobacco and electronic cigarette users. 2022 Stephenson Cancer Center Annual Cancer Research Symposium, March 4, 2022, Virtual Meeting. Virtual Poster.

9. Milton A, Chinnaiyan M, Chissoe G, Brobst D, Sadhasivam B, Ganapathy V, and Queimado L. Puffing Topography Among Exclusive Combustible Cigarette Users and Dual Users of Cigarettes and Pod-Based or Mod-Based Electronic Cigarettes. 2022 Stephenson Cancer Center Annual Cancer Research Symposium, March 4, 2022, Virtual Meeting. Virtual Poster.

10. Sadhasivam B, Manyanga J, Ganapathy V, Bouharati C, Mehta T, Mathews B, Castles S, Rubenstein D, Tackett AP, Acharya P, Zhao D, and Queimado L. Secondhand Smoke Exposure Alters Drug Transporters and Induces Cisplatin-Resistant in Head and Neck Cancer Cells. 2022 Stephenson Cancer Center Annual Cancer Research Symposium, March 4, 2022, Virtual Meeting. Virtual Poster. Won second place prize for Outstanding Poster Presentation.

11. Sadhasivam B, Raj V, Hahn EH, Ganapathy V, Chinnaiyan M, Wagener TL, and Queimado L. E-Cigarette and mitochondria: implications on oral health. 8th Annual Otolaryngology Head and Neck Surgery Research Day, May 8, 2021, OUHSC, Oklahoma City, OK. Oral Presentation.

12. Chinnaiyan M, Brobst D, Sadhasivam B, Ganapathy V, Johnston SE, Zhao YD, Krempl G, and Queimado L. DNA damage on HPRT as a biomarker of susceptibility to tobacco-induced cancer. American Association for Cancer Research (AACR) Annual Meeting 2021, April 10-15, 2021, Virtual Meeting. Virtual Poster. Awarded the Stephenson Cancer Center Trainee Research Conference and Workshop Travel Award.

13. Sadhasivam B, Jackson CG, Smith KM, Coles T, Jhingan I, Stewart R, Hahn EH, Johnston SE, Zhao YD, Ganapathy V, and Queimado L. DNA damage level correlates with grade of cervical dysplasia: A potential biomarker to assess cervical cancer risk. American Association for Cancer Research (AACR) Annual Meeting 2021, April 10-15, 2021, Virtual Meeting. Virtual Poster. Awarded the Stephenson Cancer Center Trainee Research Conference and Workshop​ Travel Award.

14. Sadhasivam B, Raj V, Hahn EH, Ganapathy V, Wagener TL, and Queimado L. E-cigarette aerosol increases mitochondrial biogenesis in oral epithelial cells. Society for Research on Nicotine and Tobacco (SRNT) 27th Annual Meeting, February 24-27, 2021, Virtual Meeting. Virtual Poster.

15. Sadhasivam B, Raj V, Hahn EH, Ganapathy V, Chinnaiyan M, Wagener TL, and Queimado L. E-Cigarette Aerosol Alters Mitochondria DNA Damage and Biogenesis. 2021 Stephenson Cancer Center Annual Cancer Research Symposium, February 5, 2021, Virtual Meeting. Virtual Poster. Won second place prize for Outstanding Poster Presentation.

16. Chinnaiyan M, Ganapathy V, Sadhasivam B, Zhao YD, Wagener TL, and Queimado L. Measuring DNA Damage to Assess the Use of Electronic Cigarettes as a Tobacco Harm Reduction Strategy. 2021 Stephenson Cancer Center Annual Cancer Research Symposium, February 5, 2021, Virtual Meeting. Virtual Poster. Won first place prize for Outstanding Poster PresentationWon Flash Talk Award.

17. Sadhasivam B, Gunderson C, Coles T, Stewart R, Hahn EH, Johnson SE, Zhao YD, Ganapathy V, and Queimado L. Nuclear DNA Damage as a Potential Tool to Predict Cervical Cancer Risk. NIH Virtual IDeA Program Meeting, September 22, 2020. Oral Presentation.

18. Sadhasivam B, Gunderson C, Coles T, Stewart R, Hahn EH, Johnston SE, Zhao YD, Ganapathy V, and Queimado L. DNA damage detection by q-PADDA: a promising tool for assessment of cervical cancer risk. 2020 Stephenson Cancer Center Annual Cancer Research Symposium, February 7, 2020, OUHSC, Oklahoma City, OK. Poster. Won third place prize for Outstanding Poster Presentation.

19. Sadhasivam B, Gunderson C, Hahn EH, Johnston SE, Zhao YD, Ganapathy V, and Queimado L. Optimization of mitochondrial DNA damage detection to predict cancer risk. 6th Annual Otolaryngology Head and Neck Surgery Research Day, April 27, 2019, OUHSC, Oklahoma City, OK. Oral Presentation.

20. Sadhasivam B, Gunderson C, Hahn E, Johnston S, Zhao Y, Ganapathy V, and Queimado L. Mitochondrial DNA damage: a promising tool to screen cervical cancer risk. 44th Annual Graduate Research Education And Technology (GREAT) Symposium, April 1-4, 2019, OUHSC, Oklahoma City, OK. Oral Presentation.

21. Manyanga J, Mehta T, Sadhasivam B, and Queimado L. Electronic cigarette aerosols increase clonogenic survival in oral cancer cells after cisplatin treatment. American Association for Cancer Research (AACR) Annual Meeting 2019, March 29-April 3, 2019, Atlanta, GA. Oral Presentation. Cancer Research 79 (13 Supplement) 80-80 2019 doi: 10.1158/1538-7445.AM2019-80Awarded the Stephenson Cancer Center Trainee Research Conference and Workshop Travel Award.

22. Sadhasivam B, Gunderson C, Hahn EH, Johnston SE, Zhao YD, Ganapathy V, and Queimado L. Mitochondrial DNA damage: a promising tool to screen cervical cancer risk. American Association for Cancer Research (AACR) Annual Meeting 2019, March 29-April 3, 2019, Atlanta GA. Oral Presentation. Cancer Research 79 (13 Supplement) 4219-4219 2019 doi: 10.1158/1538-7445.AM2019-4219.

23. Sadhasivam B, Gunderson C, Hahn EH, Johnston SE, Zhao YD, Ganapathy V, and Queimado L. A novel promising biomarker to assess cervical cancer risk. 2019 Stephenson Cancer Center Annual Cancer Research Symposium, February 1, 2019, OUHSC, Oklahoma City, OK. Poster.

24. Manyanga J, Mehta T, Sadhasivam B, and Queimado L. Clonogenic survival after cisplatin: Effects of e-cigarette exposure. 2019 Stephenson Cancer Center Annual Cancer Research Symposium, February 1, 2019, OUHSC, Oklahoma City, OK. Poster. Won third place prize for Outstanding Poster Presentation.

25. Sadhasivam B and Queimado L. Mitochondrial DNA damage. Mitochondria and Metabolic Regulation Research Retreat, April 20, 2018, OUHSC, Oklahoma City, OK. Oral Presentation.

26. Sadhasivam B, Brobst D, Ganapathy V, Zhao D, and Queimado L. Cancer risk assessment in tobacco exposed populations. 5th Annual Otolaryngology Head and Neck Surgery Research Day, April 7, 2018, OUHSC, Oklahoma City, OK. Oral Presentation.

27. Sadhasivam B, Brobst D, Ganapathy V, Zhao D, and Queimado L. DNA Damage detection: sensitivity among qPADDA, comet and LORD-Q assays. 4th Annual Otolaryngology Head and Neck Surgery Research Day, April 8, 2017, OUHSC, Oklahoma City, OK. Oral Presentation.