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Tuyen T. Dang, Ph.D.
Neurosurgery

Tuyen T. Dang, Ph.D.

Ph.D., Research


Education:

Oregon State University     2004-2008

B.S. Biochemistry/Biophysics     June 2008

University of Texas Southwestern Medical Center     2008-2014

Ph.D. Cancer Biology     December 2014


Clinical/Research Interests:

Research Experiences:

Oregon State University     2005-2008

Research Assistant, Dr. Christopher Matthews’s Lab

Oregon State University     Summer 2006

HMMI Summer Fellow, Dr. Christopher Matthews’s Lab

University of Texas Southwestern Medical Center     Summer 2007

SURF Fellow, Dr. Hiromi Yanagisawa’s Lab

University of Texas Southwestern Medical Center     2009-2014

Graduate Student, Dr. Gray Pearson’s Lab

University of Texas Southwestern Medical Center     2014-2015

Post-doctoral Fellow, Dr. Gray Pearson’s Lab

University of Oklahoma Health Science Center     2015-present

Post-doctoral Fellow, Dr. Julio Morales’s Lab                 


Select Publications:

  1. Jaykumar AB, Jung JU, Parida PK, Dang TT, Wichaidit C, Kannangara AR, Earnest S, Goldsmith EJ, Pearson GW, Malladi S, Cobb MH. WNK1 Enhances Migration and Invasion in Breast Cancer Models. Mol Cancer Ther. 2021 Jul 12;. doi: 10.1158/1535-7163.MCT-21-0174. [Epub ahead of print] PubMed PMID: 34253593.
  2. Dang TT, Morales JC. Loss of CENP-I Impairs Homologous Recombination and Sensitizes Cells to PARP1 Inhibition. Cancers (Basel). 2021 Jun 26;13(13). doi: 10.3390/cancers13133202. PubMed PMID: 34206916; PubMed Central PMCID: PMC8267748.
  3. Dang TT, McIntosh AT, Morales JC, Pearson GW. miR614 Expression Enhances Breast Cancer Cell Motility. Int J Mol Sci. 2020 Dec 24;22(1). doi: 10.3390/ijms22010112. PubMed PMID: 33374314; PubMed Central PMCID: PMC7801944.
  4. Westcott JM, Camacho S, Nasir A, Huysman ME, Rahhal R, Dang TT, Riegel AT, Brekken RA, Pearson GW. ΔNp63-Regulated Epithelial-to-Mesenchymal Transition State Heterogeneity Confers a Leader-Follower Relationship That Drives Collective Invasion. Cancer Res. 2020 Sep 15;80(18):3933-3944. doi: 10.1158/0008-5472.CAN-20-0014. Epub 2020 Jul 13. PubMed PMID: 32661136.
  5. Dang TT, Morales JC. XRN2 Links RNA:DNA Hybrid Resolution to Double Strand Break Repair Pathway Choice. Cancers (Basel). 2020 Jul 7;12(7). doi: 10.3390/cancers12071821. PubMed PMID: 32645903; PubMed Central PMCID: PMC7408924.
  6. Dang TT, Morales JC. Involvement of POLA2 in Double Strand Break Repair and Genotoxic Stress. Int J Mol Sci. 2020 Jun 15;21(12). doi: 10.3390/ijms21124245. PubMed PMID: 32549188; PubMed Central PMCID: PMC7352189.
  7. Morales JC, Richard P, Patidar PL, Motea EA, Dang TT, Manley JL, Boothman DA. XRN2 Links Transcription Termination to DNA Damage and Replication Stress. PLoS Genet. 2016 Jul;12(7):e1006107. doi: 10.1371/journal.pgen.1006107. eCollection 2016 Jul. PubMed PMID: 27437695; PubMed Central PMCID: PMC4954731.
  8. Dang TT, Westcott JM, Maine EA, Kanchwala M, Xing C, Pearson GW. ΔNp63α induces the expression of FAT2 and Slug to promote tumor invasion. Oncotarget. 2016 May 10;7(19):28592-611. doi: 10.18632/oncotarget.8696. PubMed PMID: 27081041; PubMed Central PMCID: PMC5053748.
  9. Maine EA, Westcott JM, Prechtl AM, Dang TT, Whitehurst AW, Pearson GW. The cancer-testis antigens SPANX-A/C/D and CTAG2 promote breast cancer invasion. Oncotarget. 2016 Mar 22;7(12):14708-26. doi: 10.18632/oncotarget.7408. PubMed PMID: 26895102; PubMed Central PMCID: PMC4924746.
  10. Dang TT, Esparza MA, Maine EA, Westcott JM, Pearson GW. ΔNp63α Promotes Breast Cancer Cell Motility through the Selective Activation of Components of the Epithelial-to-Mesenchymal Transition Program. Cancer Res. 2015 Sep 15;75(18):3925-35. doi: 10.1158/0008-5472.CAN-14-3363. Epub 2015 Aug 19. PubMed PMID: 26292362; PubMed Central PMCID: PMC4573836.
  11. Westcott JM, Prechtl AM, Maine EA, Dang TT, Esparza MA, Sun H, Zhou Y, Xie Y, Pearson GW. An epigenetically distinct breast cancer cell subpopulation promotes collective invasion. J Clin Invest. 2015 May;125(5):1927-43. doi: 10.1172/JCI77767. Epub 2015 Apr 6. PubMed PMID: 25844900; PubMed Central PMCID: PMC4463195.
  1. Dang TT, Prechtl AM, Pearson GW. Breast cancer subtype-specific interactions with the microenvironment dictate mechanisms of invasion. Cancer Res. 2011 Nov 1;71(21):6857-66. doi: 10.1158/0008-5472.CAN-11-1818. Epub 2011 Sep 9. PubMed PMID: 21908556; PubMed Central PMCID: PMC3206184.
  1. Yang C, Sudderth J, Dang T, Bachoo RM, McDonald JG, DeBerardinis RJ. Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling. Cancer Res. 2009 Oct 15;69(20):7986-93. doi: 10.1158/0008-5472.CAN-09-2266. Epub 2009 Oct 13. PubMed PMID: 19826036; PubMed Central PMCID: PMC2764330.