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Team Members

Jimmy Manyanga, PhD
Otolaryngology

Jimmy Manyanga, PhD

Postdoctoral Fellow

Jimmy earned his PhD in Cell Biology from the University of Oklahoma Health Sciences Center. His PhD dissertation focused on the impact of e-cigarettes on cancer risk and chemotherapy resistance in oral epithelial cell lines. As a current team member of The Dunn Laboratory at Washington University School of Medicine, his research focuses on neoantigen discovery and targeting. 

Select Publications:

Recent Publications:

1. Manyanga J, Queimado L (Advisor). Electronic Cigarettes: Implications on Cancer Risk and Cisplatin Resistance in Oral Epithelial Cells. Order No. 28030538 The University of Oklahoma Health Sciences Center, 2020. ProQuest Dissertations Publishing. 2021 Jan 20.

2. Manyanga J, Ganapathy V, Bouharati C, Mehta T, Sadhasivam B, Acharya P, Zhao D, and Queimado L. Electronic cigarette aerosols alter the expression of cisplatin transporters and increase drug resistance in oral cancer cells. Sci Rep. 2021 Jan 19; 11(1):1821. doi: 10.1038/s41598-021-81148-0. PMID: 33469038. PMCID: PMC7815770.

3. Ganapathy V, Manyanga J, Brame L, McGuire D, Sadhasivam B, Floyd E, Rubenstein DA, Ramachandran I, Wagener T, and Queimado L. Electronic cigarette aerosols suppress cellular antioxidant defenses and induce significant oxidative DNA damage. PLoS One. 2017; 12(5):e0177780. doi: 10.1371/journal.pone.0177780. eCollection 2017. PMID: 28542301. PMCID: PMC5436899. 

Selected Conference Presentations:

1. Sadhasivam B, Manyanga J, Ganapathy V, Bouharati C, Mehta T, Mathews B, Castles S, Rubenstein D, Tackett AP, Acharya P, Zhao D, and Queimado L. Cisplatin Resistance In Head And Neck Cancer: Impact Of Secondhand Smoke Exposure. American Head and Neck Society (AHNS) Annual Meeting at COSM 2022, April 27-28, 2022, Dallas, TX. Poster. Awarded the Stephenson Cancer Center Trainee Research Conference and Workshop Travel Award.

2. Sadhasivam B, Manyanga J, Ganapathy V, Bouharati C, Mehta T, Mathews B, Castles S, Rubenstein D, Tackett AP, Acharya P, Zhao D, and Queimado L. Cisplatin Resistance In Head And Neck Cancer: Impact Of Secondhand Smoke Exposure. American Head and Neck Society (AHNS) Annual Meeting at COSM 2022, April 27-28, 2022, Dallas, TX. Research Paper. Received the Robert Maxwell Byers Award for the best clinical research paper submitted to the American Head and Neck Society Annual Meeting at COSM 2022.

3. Ganapathy V, Brobst D, Manyanga J, and Queimado L. E-Cigarette Aerosol Increases Oxidative Stress And Alters Inflammatory Markers In Oral Cells. 9th Annual Otolaryngology Head and Neck Surgery Research Day, April 2, 2022, OUHSC, Oklahoma City, OK, Oral Presentation.

4. Sadhasivam B, Manyanga J, Ganapathy V, Bouharati C, Mehta T, Mathews B, Castles S, Rubenstein D,  Tackett AP, Acharya P, Zhao D, and Queimado L. Secondhand Smoke Exposure Alters Drug Transporters and Induces Cisplatin-Resistant in Head and Neck Cancer Cells. 9th Annual Otolaryngology Head and Neck Surgery Research Day, April 2, 2022, OUHSC, Oklahoma City, OK, Oral Presentation. 

5. Ganapathy V, Brobst D, Manyanga J, and Queimado L. E-Cigarette Aerosol Alters the Expression of Antioxidant and Detoxification Enzymes and Inflammatory Markers in Lung Cells. 2022 Stephenson Cancer Center Annual Cancer Research Symposium, March 4, 2022, Virtual Meeting. Virtual Pre-Symposium Poster.

6. Sadhasivam B, Manyanga J, Ganapathy V, Bouharati C, Mehta T, Mathews B, Castles S, Rubenstein D, Tackett AP, Acharya P, Zhao D, and Queimado L. Secondhand Smoke Exposure Alters Drug Transporters and Induces Cisplatin-Resistant in Head and Neck Cancer Cells. 2022 Stephenson Cancer Center Annual Cancer Research Symposium, March 4, 2022, Virtual Meeting. Virtual Poster.

7. Manyanga J, Ganapathy V, Brobst D, Wren J, and Queimado L. Exposure to E-Cigarette Aerosol Extracts Alters the Expression of Cytochrome P450 Mono-Oxygenase Enzymes. Society for Research on Nicotine and Tobacco (SRNT) 27th Annual Meeting, February 24-27, 2021, Virtual Meeting. Oral Pre-Recorded Virtual Online Podium Presentation.

8. Manyanga J, Mehta T, Sadhasivam B, and Queimado L. Effects of E-cigarette Aerosol Extracts on Cytochrome P450 Mono-oxygenase Enzymes. 2020 Stephenson Cancer Center Annual Cancer Research Symposium, February 7, 2020, OUHSC, Oklahoma City, OK. Poster.

9. Manyanga J, Bouharati C, Vengatesh G, Sadhasivam B, and Queimado L. Electronic Cigarettes: Implications on Cancer Risk and Cisplatin Resistance in Oral Epithelial Cells. Washington University, January 21, 2020, St. Louis, MO. Oral Presentation.

10. Manyanga J, Bouharati C, Sadhasivam B, and Queimado L. E-cigarettes Aerosol Extracts Enhance Drug Transporters and Induce Cisplatin Resistance in Oral Cancer Cells. Cell Biology Research Retreat, December 13, 2019, OUHSC, Oklahoma City, OK. Poster.

11. Manyanga J, Bouharati C, Vengatesh G, Sadhasivam B, and Queimado L. Electronic Cigarettes: Implications on Cancer Risk and Cisplatin Resistance in Oral Epithelial Cells. Crown-Bio, May 10, 2019, San Diego, CA. Oral Presentation.

12. Manyanga J, Bouharati C, Mehta TR, Sadhasivam B, Zhao YD, Ganapathy V, and Queimado L. In vitro effects of e-cigarettes in therapy resistance: Implications for clinical practice. 6th Annual Otolaryngology Head and Neck Surgery Research Day, April 27, 2019, OUHSC, Oklahoma City, OK. Oral Presentation.

13. Manyanga J, Mehta T, and Queimado L. Electronic cigarette aerosols increase clonogenic survival in oral cancer cells after cisplatin treatment. 44th Annual Graduate Research Education And Technology (GREAT) Symposium, April 1-4, 2019, OUHSC, Oklahoma City, OK. Oral Presentation.

14. Manyanga J and Queimado L. The perils of e-cigarettes: Cancer risk and therapy resistance. 44th Annual Graduate Research Education And Technology (GREAT) Symposium, April 1-4, 2019, OUHSC, Oklahoma City, OK. Oral Presentation.

15. Manyanga J, Mehta T, Sadhasivam B, and Queimado L. Electronic cigarette aerosols increase clonogenic survival in oral cancer cells after cisplatin treatment. American Association for Cancer Research (AACR) Annual Meeting 2019, March 29-April 3, 2019, Atlanta, GA. Oral Presentation. Cancer Research 79 (13 Supplement) 80-80 2019 doi: 10.1158/1538-7445.AM2019-80. Awarded the Stephenson Cancer Center Trainee Research Conference and Workshop​ Travel Award.

16. Manyanga J, Bouharati C, Ganapathy V, Sadhasivam B, and Queimado L. Exposure to Electronic Cigarettes Aerosol Increases Cisplatin Resistance in Pharyngeal Cancer Cells. Society for Research on Nicotine and Tobacco (SRNT) 25th Annual Meeting, February 20-23, 2019, San Francisco, CA. Oral Presentation.

17. Manyanga J, Mehta T, Sadhasivam B, and Queimado L. Clonogenic survival after cisplatin: Effects of e-cigarette exposure. 2019 Stephenson Cancer Center Annual Cancer Research Symposium, February 1, 2019, OUHSC, Oklahoma City, OK. Poster. Won third place prize for Outstanding Poster Presentation.

18. Manyanga J, Bouharati C, Ganapathy V, Sadhasivam B, Mehta T, and Queimado L. Electronic Cigarettes: Implications on Cancer Risk and Cisplatin Resistance in Oral Epithelial Cells. Cell Biology Student Research Seminar, November 6, 2018, OUHSC, Oklahoma City, OK. Oral Presentation.

19. Manyanga J, Bouharati C, Sadhasivam B, Ganapathy V, and Queimado L. Secondhand smoke exposure induces cisplatin resistance in oral cancer cells. Cell Biology Research Day, September 26, 2018, OUHSC, Oklahoma City, OK. Oral Presentation.

20. Manyanga J, Ganapathy V, and Queimado L. The electronic cigarette enigma: role in DNA damage and stemness. 43rd Annual Graduate Research Education And Technology (GREAT) Symposium, April 9-12, 2018, OUHSC, Oklahoma City, OK. Oral Presentation. Won Flash Talk Winner (Judge) prize.

21. Manyanga J, Bouharati C, Ganapathy V, and Queimado L. Mechanisms of Cisplatin Resistance Induced by Secondhand Smoke Exposure. 43rd Annual Graduate Research Education And Technology (GREAT) Symposium, April 9-12, 2018, OUHSC, Oklahoma City, OK. Oral Presentation.

22. Manyanga J, Sadhasivam B, Bouharati C, Ganapathy V, Mehta T, Brobst D, and Queimado L. Mechanisms of Cisplatin Resistance Induced by Secondhand Smoke Exposure. 5th Annual Otolaryngology Head and Neck Surgery Research Day, April 7, 2018, OUHSC, Oklahoma City, OK. Oral Presentation.

23. Castles S, Mehta T, Manyanga J, and Queimado L. What is the outcome of removing smoke exposure during cisplatin treatment? An in vitro study. 5th Annual Otolaryngology Head and Neck Surgery Research Day, April 7, 2018, OUHSC, Oklahoma City, OK. Oral Presentation. Won Jesus E. Medina Award for Excellence in Research by a Medical Student.

24. Manyanga J, Sadhasivam B, Bouharati C, Ganapathy V, Mehta T, Brobst D, and Queimado L. Secondhand smoke exposure increases cisplatin resistance in oral cancer cells. Society for Research on Nicotine and Tobacco (SRNT) 24th Annual Meeting, February 21-24, 2018, Baltimore, MD. Poster.

25. Manyanga J, Sadhasivam B, Bouharati C, Ganapathy V, Mehta T, Brobst D, and Queimado L. Secondhand smoke exposure increases cisplatin resistance in oral cancer cells. 2018 Stephenson Cancer Center Annual Cancer Research Symposium, February 2, 2018, OUHSC, Oklahoma City, OK. Oral Presentation.

26. Manyanga J, Bouharati C, Ganapathy V, and Queimado L. Electronic cigarettes: effects on DNA damage, cisplatin resistance and stemness in oral epithelial cells. Cell Biology (Cell 6010) Graduate Research Seminar, November 28, 2017, OUHSC, Oklahoma City, OK. Oral Presentation.

27. Manyanga J, Ganapathy V, and Queimado L. Electronic cigarettes: implications in epithelial cancer and non-cancer stemness. Cell Biology Research Retreat, October 28, 2017, OUHSC, Oklahoma City, OK. Oral Presentation.

28. Manyanga J, Sadhasivam B, Ganapathy V, and Queimado L. Secondhand Smoke Increases Cisplatin Resistance in Oral Cancer Cells. 4th Annual Otolaryngology Head and Neck Surgery Research Day, April 8, 2017, OUHSC, Oklahoma City, OK. Oral Presentation.

29. Manyanga J, Ganapathy V, Rubenstein D, Wagener T, and Queimado L. Electronic cigarettes increase cellular reactive oxygen species and reduce cellular antioxidant capacity. Society for Research on Nicotine and Tobacco (SRNT) 23rd Annual Meeting, March 8-11, 2017, Florence, Italy. Poster.

30. Manyanga J, Bouharati C, Ganapathy V, and Queimado L. Secondhand smoke: effects on drug resistance, and stem cell proliferation in oral epithelial cells. 2017 Stephenson Cancer Center Annual Cancer Research Symposium, January 27, 2017, OUHSC, Oklahoma City, OK. Oral Presentation.

31. Manyanga J, Bouharati C, Ganapathy V, and Queimado L. Electronic cigarettes increase stemness and drug resistance in cancer and non-cancer oral epithelial cells. Cell Biology Research Day, November 18, 2016, OUHSC, Oklahoma City, OK. Poster.

32. Manyanga J, Bouharati C, Ganapathy V, and Queimado L. Electronic cigarettes: effects on DNA damage, cisplatin resistance, and stemness in oral epithelial cells. Cell Biology (Cell 6010) Graduate Research Seminar, November 15, 2016, OUHSC, Oklahoma City, OK. Oral Presentation.

33. Manyanga J, Bouharati C, Ganapathy V, and Queimado L. Electronic cigarette aerosol increases cisplatin resistance in oral epithelial cancer cells. 3rd Annual Otorhinolaryngology Research Day, May 21, 2016, OUHSC, Oklahoma City, OK. Oral Presentation.

34. Manyanga J, Bouharati C, Ganapathy V, and Queimado L. Electronic Cigarettes increase the stemness and drug resistance in cancer and non-cancer epithelial cells.  41st Annual Graduate Research Education And Technology (GREAT) Symposium, March 28-31, 2016, OUHSC, Oklahoma City, OK. Poster.

35. Manyanga J, Ganapathy V, and Queimado L. Active and passive smoking increase epithelial normal and cancer stemness. Society for Research on Nicotine and Tobacco (SRNT) 22nd Annual Meeting, March 2-5, 2016, Chicago, IL. Poster. Awarded the 2016 SRNT Health Disparities Network Travel Scholarship.

36. Mathews B, Manyanga J, Ganapathy V, and Queimado L. Nicotine actives the WNT/beta-catenin pathway and increases the stemness of head and neck cancer cells. Society for Research on Nicotine and Tobacco (SRNT) 22nd Annual Meeting, March 2-5, 2016, Chicago, IL. Poster. Awarded the 2016 SRNT Health Disparities Network Travel Scholarship.

37. Manyanga J, Bouharati C, Ganapathy V, and Queimado L. Active and passive smoking increase epithelial normal and cancer stemness and induce drug resistance. Stephenson Cancer Center Cancer Research Symposium, January 29, 2016, OUHSC, Oklahoma City, OK. Poster. Won second place prize for Best Poster Presentation.

38. Manyanga J, Ganapathy V, Rubenstein D, and Queimado L. Exposure to mainstream and sidestream smoke increases the stemness of epithelial normal and cancer cells. Stephenson Cancer Center Cancer Research Symposium, January 30, 2015, OUHSC, Oklahoma City, OK. Poster.