Dr. Ofman research focuses on a translational approach to bring perinatal bedside findings on organ and cellular oxidative stress and mitochondrial function to laboratory explanations of disease mechanisms. He studies the effects of early life environmental, nutritional and clinical exposures to long term human diseases.
Medical School: Universidad Favaloro, Buenos Aires, Agrentina
Residency: The Univeristy of Texas Southwestern, Dallas, Texas
Fellowship: Northwestern University, Chicago, Illinois
American Board of Pediatrics
The Ofman laboratory works focuses on very early determinants of long-term preterm outcomes. Research is targeted at understanding bedside and laboratory environmental exposures that modulate the developing cardiopulmonary system offering a window of opportunity to improve the undesirable consequences of premature birth.
Dr. Ofman is specifically researching phenotype-specific disease determinants, from molecular alterations in mitochondrial function to genetic mutations or gene-by-environment interactions that leads to cardiopulmonary outcomes in newborns. He is also interested in finding specific physiologic predictors of bronchopulmonary, a form of preterm pulmonary disease, and aligning those with laboratory findings. The laboratory hopes to develop combine molecular mechanism with physiologic and bedside biomarkers hoping to identifying early disease mechanisms and potential modifiable risk factors and therapeutic targets.
Select Honors & Accomplishments:
2019 - Thrasher Early Career Investigator Award
2018 - Fellowship Basic Science Award – Northwestern University
2017 - Selected for the Annual NICHD Young Investigator Conference on Maternal-Fetal-Neonatal-Reproductive Medicine
2013 - AAP International Elective Award
2009 - Honor Diploma for Academic Excellence, Universidad Favaloro, Argentina
Ofman G, Tipple. Thiol-redox regulation in lung development and vascular remodeling. Antioxid Redox Signal. 2019 Jan 16. doi: 10.1089/ars.2018.7712
Ofman G, Tipple T Antioxidants & bronchopulmonary dysplasia: Beating the system or beating a dead horse? Free Radical Biology and Medicine, 2019 doi: 10.1016/j.freeradbiomed.2019.01.038.
Ofman G, Caballero M, Alavarez-Paggi D, et al. : The Discovery BPD (D-BPD) program: A prospective translational collaborative study of chronic lung disease of prematurity BMC Peds 2019 https://doi.org/10.1186/s12887-019-1610-8
Ofman G, Pradarelli B, Caballero M, et al. : Respiratory failure and death in vulnerable premature children with lower respiratory tract illness JID 2020 doi:10.1093/infdis/jiaa046