Dr. Weston received at BS in Chemistry with Honors and Distinction from Indiana University, Bloomington IN in 1982. He then attended the Indiana University School of Medicine, Indianapolis, IN graduating followed by a three year Internal Medicine Residency at University of Iowa Hospital and Clinics in Iowa City, IA. A Gastroenterology-Hepatology Fellowship was completed in 1992 at University of Kansas Medical Center, Kansas City Kansas, where he remained for the next 12 years a faculty member, promoted to Associate Professor of Medicine and became the GI-Hepatology Section Chief at the Kansas City, VAMC. During his tenure in Kansas CIty, Dr. Weston co-authored over 50 original manuscripts, presented over 100 abstracts and wrote 2 book chapters and undertook research. Clinical and translational research was undertaken in Helicobacter pylori infection and Gastric Lymphoma as well as the risk stratification of Barrett’s Esophagus into cancer. Clinical research also focused on conducting phase 2 and 3 clinical trials on chronic hepatitis C and B treatment. The academic environment also created an opportunity to master many diagnostic and therapeutic skills including endoscopic ultrasonography, photodynamic therapy, Nd:YAG laser ablation, chromoendoscopy and magnification endoscopy. Although he has a wide number of clinical interests involving the pancreas, colon, liver and esophagus, major clinical research interests currently involve non-invasive imaging of the liver for assessment of severity of steatosis and fibrosis, the molecular stratification of cystic neoplasms of the pancreas, and breath testing for gastric emptying and bacterial overgrowth. Dr. Weston also has served as Governor for the American College of Gastroenterology for both Missouri and Kansas and is a reviewer for several gastroenterology journals. Dr. Weston is excited to a member of the OU Medical Staff and is dedicated at giving his patients state of the art, compassionate care.
Indianapolis University, Indianapolis, IN
National Board of Medical Examiners 1988
American Board of Internal Medicine 1990
American Board of Internal Medicine-Gastroenterology Subspecialty 1993-Present
University of Iowa Hospital and Clinics
University of Kansas School of Medicine
Clinical Interests: Pancreas, Colon, Liver and Esophagus
Although my interests in gastroenterology are diverse, variety of clinical research interests, the major clinical research interests involve: 1) All aspects of Barrett's esophagus (screening, endoscopic diagnosis, ablation, complications), 2) clinical issues surrounding Chronic Liver Disease including non-invasive Fibrosis/Steatosis imaging/testing [Elastography] and Chronic Hepatitis C, 3) premalignant and malignant gastric Helicobacter pylori diseases, 4) Irritable Bowel: incorporation of breath testing and SMARTPill to direct therapy. Additional clinical research interests include: a) clinical aspects of GI oncology including – diagnostic, molecular-genetic aspects including genetic testing/counseling, and therapeutic EUS issues, palliative treatment of tumors of with expandable metallic stents, Nd:YAG laser or photodynamic therapy (PDT), b) high resolution- magnification endoscopy and chromoendoscopy for early diagnosis of high grade dysplasia/early cancer within Barrett’s Esophagus, stomach, and colon (indigo carmine green, Lugol’s iodine, and methylene blue).
Select Honors & Accomplishments:
- Phi Beta Kappa Honor Society
- Young Investigator Award 1992 from Merck Human Health Division for Microscopic Changes in the Terminal Ileum in Chronic Left-sided Ulcerative Colitis
- Faculty Domestic Travel Award, $400, to San Diego CA in May 1995 to give 4 poster presentations
- Merit Review Award (3 year grant starting 4/1/98) totaling $285,100 for Molecular Genetics of Helicobacter pylori associated Gastric MALT and MALT Lymphoma
- DDW 1998 poster of distinction: Badr AS, Weston AP. Prospective multivariate analysis of factors predictive of endoscopic and histologic regression of Barrett’s esophagus during long-term follow up.
- DDW 1999 poster of distinction: Sharma P, Topalovski M, Sampliner RE, Weston AP. H pylori eradication dramatically improves inflammation in the gastric cardia (carditis). Gastroenterology 1999;116:A308.
- DDW 1999 poster of distinction: Sharma P, Weston AP, Morales TG, Mayo M, Sampliner RE. Relative risk of dysplasia for patients with intestinal metaplasia (IM) in the distal esophagus versus the gastric cardia. Gastroenterology 1999;116:A308.
- ACG Governors Award for Clinical Excellence in Clinical Research. ACG Meeting 1999, Phoenix AZ: Weston AP, Banerjee SK, Persons D, Cherian R, Sharma P. P53 positivity in low-grade dysplasia (LGD) in Barrett’s esophagus: marker predictive of progression to cancer or multifocal high-grade dysplasia (mHGD).
- Auxillary Award for best scientific paper submitted by a Member/Fellow of the College: ACG 1999 Phoenix AZ. Elevation of cytokine and peptide growth factors in gastric juice of patients with Barrett’s esophagus: its potential clinical significance.
- DDW 2000 Poster of Distinction: Sharma P, Mayo MS, Topalovski M, Weston AP. Increased detection of patients with short segment Barrett’s esophagus (SSBE) using chromoendoscopy.
- DDW 2000 Poster of Distinction: Sharma P, Topalovski M, Weston, AP, Sampliner RE. Cytokeratin 7 & 20 staining patterns in patients with cardia intestinal metaplasia associated with either Barrett’s esophagus or H. pylori.
- p53 and Barrett’s. American College of Gastroenterology Governor’s Award for Excellence in Clinical Research. ACG Meeting Annual Meeting, October 2001, Las Vegas NV.