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Department of Oncology Science

The Department of Oncology Science seeks to provide a research home to trainees, young investigators, and national/international leaders working in the areas of cancer prevention, diagnosis, treatment, and cure. We intend to achieve this through programs of excellence in research, education, outreach, and cost-effective patient care. The Department of Oncology Science is committed to facilitating interdisciplinary, collaborative, and innovative team-science to make OU Health Sciences Center a world-leader in translational cancer research.


Immunohistochemical (IHC) Analysis

Immunohistochemical (IHC) Analysis: IHC is a method to determine the location of proteins in tissue sections, it offers some quantitation and enables the observation of processes in the context of intact tissue. As shown in the picture: Blue (Nucleus), Pink (MUC1), and Green (alpha-SMA).

PDAC Organoids

PDAC Organoids: An organoid is a 3D multicellular in vitro tissue construct that mimics a corresponding tumor, such that it can be used to study aspects of that organ in the tissue culture dish.

Tumor cells, Fibroblasts, NK cells

Coculture is a key tool to understand the interaction between various cell types in cell culture settings. As shown in the picture: Tumor cells (pink), Fibroblasts (red), NK cells (green)

Omics

Omics: Genomics, Transcriptomics, and Metabolomics are established tools to understand the disease’s molecular mechanisms.

Cachexia in PDAC

Cachexia in PDAC: Cachexia is the loss of skeletal muscle mass that cannot be fully reversed by conventional nutritional therapy and leads to progressive functional impairment. It is a metabolic syndrome that contributes to significant mortality in cancer patients. As shown in the picture: Right (Healthy Muscle) Left (Cachectic muscle)

Research Themes

The department is focused on several key areas of cancer research.

  • Signaling basis of cancer cell growth, cell death, and senescence
  • Mechanisms of chemo- and radiotherapy resistance
  • Metabolic alterations in cancer cells supporting survival under various abiotic stresses, including hypoxia, low pH, and nutrient deprivation
  • Metabolic vulnerabilities of various cancer types
  • Cancer-induced systemic organ failure, including cachexia
  • Tumor immunology, immunotherapies, and immunometabolism
  • Epigenetic and transcriptomic alterations and intratumoral heterogeneity
  • Cancer health disparity research

Department of Oncology Seminar Series

The Department of Oncology Seminar Series is focused on current and emerging areas of cancer research. The seminars are organized with the goal of educating faculty, postdocs, students, and other trainees about the latest advancements in the field and facilitating interdisciplinary collaborations. 

Upcoming seminars currently being planned!

News and Events

Funding Opportunities

https://research.ouhsc.edu/Research-Administration/Grant