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Cardiovascular Research

Patrick Crosswhite and Zhongjie Sun.  Inhibition of phosphodiesterase 1 attenuates cold-induced pulmonary hypertension.  Hypertension. 61:585-592,2013

Xiuqing Wang and Zhongjie Sun.  Normal IgG downregulates the intracellular superoxide and attenuates migration and permeability in human aortic endothelial cells from a hypertensive patient.  Hypertension. 60:818-826, 2012.

Xiuqing Wang, Lucille Skelley, Bo Wang and Zhongjie Sun. AAV-based RNAi silencing of NADPH oxidase gp91phox attenuates cold-induced cardiovascular dysfunction. Human Gene Ther. 23(9):1016-1026, 2012.

Yi Lin and Zhongjie Sun. Klotho enhances glucose-induced insulin secretion in Min6 β cells by upregulating plasma membrane retention of TRPV2.  Endocrinology.  153(7):3029-3039, 2012.

Yuhong Wang and Zhongjie Sun. Klotho suppresses NADPH oxidase activity and superoxide production in rat aortic smooth muscle cells. Aging Cell. 11(3):410-417, 2012.

Karigowda J. Dammanahalli, Xiuqing Wang and Zhongjie Sun. Genetic interleukin-10 deficiency causes vascular remodeling via the upregulation of Nox1. J Hypertens. 29(11):2116-2125, 2011.  (*Editorial comment. 29:2061-2063, 2011).

Zhong Zuo, Han Lei, Xiuqing Wang, Yuhong Wang, William Sonntag and Zhongjie Sun.  Aging-related renal damage is associated with decreased klotho expression and increased superoxide production.  AGE. 33:261-274, 2011.

Yi Lin and Zhongjie Sun. Thyroid hormone ameliorates diabetic nephropathy in a mouse model of type II diabetes.  J Endocrinol. 209(2):185-191, 2011.  (*Top 10 most frequently downloaded article).

Yi Lin and Zhongjie Sun. T3 enhances insulin-induced glucose uptake via the Akt-VAMP2 pathway in 3T3-L1 adipocytes.  J Cell Physiol. 226:2625-2632, 2011.

Patrick Crosswhite and Zhongjie Sun.  RNA inhibition of interleukin-6 gene attenuates cold-induced hypertension.  Hypertension.  55:1484-1491, 2010.

Yi Lin and Zhongjie Sun.  Thyroid hormone potentiates insulin signaling, attenuates hyperglycemia and reverses insulin resistance in type II diabetes. British J Pharmacol. 162(3):597-610, 2010.

Patrick Crosswhite and Zhongjie Sun. Nitric oxide, oxidative stress and inflammation in pulmonary arterial hypertension.  J Hypertens. 28(2):201-212, 2010.

Xiuqing Wang and Zhongjie Sun. RNAi inhibition of brain klotho potentiates cold-induced elevation of blood pressure.  Physiol Genom. 41:120-126, 2010.

Xiuqing Wang and Zhongjie Sun. Thyroid hormone induces vascular smooth muscle cell proliferation through a new TRα1-Nox1 pathway. J Cell Mol Med. 14(2):368-380, 2010.

Yi Lin and Zhongjie Sun. Current views of type II diabetes. J Endocrinol. 204(1):1-11, 2010.

Zhongjie SunCardiovascular responses to cold exposure. Frontiers in Biosci. 2:495-503, 2010. (invited review).

Yuhong Wang and Zhongjie Sun In vivo klotho gene delivery attenuates spontaneous hypertension and renal damage.  Hypertension. 54:810-817, 2009.

Yuhong Wang and Zhongjie Sun.  Current understanding of klothoAging Res Rev. 8:43-51, 2009. (*Top 5 most frequently cited article)

Karigowda J. Dammanahalli and Zhongjie Sun. Endothelin-1 inhibits Nox1 activity in human abdominal aorta cells: a novel function of ETB1 receptors.  Endocrinology. 149(10):4979-4987, 2008.

Zhongjie Sun, Mahajoub Bello Roufai and Xiuqing Wang. RNAi inhibition of  mineralocorticoid receptors prevents the development of cold-induced hypertension.  Am J Physiol Heart & Circ Physiol. 294:H1880-H1887, 2008.

Karigowda J. Dammanahalli and Zhongjie Sun. Endothelins and NADPH oxidases in the cardiovascular system. Clin Exp Pharmacol Physiol. 35:2-6, 2008.

Mahajoub Bello Roufai, Hua Li and Zhongjie Sun. Heart-specific inhibition of proto-oncogene c-myc delays and attenuates cold-induced hypertension and cardiac hypertrophy. Gene Ther. 14:1406-1416, 2007.

Xiuqing Wang, Lucille Skelley, Robert Cade and Zhongjie Sun.  AAV delivery of mineralocorticoid receptor shRNA prevents progression of cold-induced hypertension and attenuates renal damage. Gene Ther. 13:1097-1103, 2006.

Zhongjie Sun. Genetic AVP deficiency abolishes cold-induced diuresis but does not attenuate cold-induced hypertension.  Am J Physiol Renal Physiol.  290:F1472-F1477, 2006.

Gin-Fu Chen and Zhongjie Sun. Effects of chronic cold exposure on the endothelin system. J Appl Physiol. 100:1719-1726, 2006.

Zhongjie Sun. Recent technical advances in molecular cardiology. Can J Cardiol. 22(3):235-240, 2006.

Xiuqing Wang, Robert Cade, and Zhongjie Sun. Expression of human eNOS in cardiac and endothelial cells. Methods Mol Med. 112:91-107, 2005.

Zhongjie Sun and Zhonge Zhang. Historic perspectives and recent advances in major animal models of hypertension. (Invited Review). Acta Pharmacol. Sinica. 26 (3):295-301, 2005.

Zhongjie Sun. An introduction to Molecular Cardiology. Methods Mol Med. 112:3-12, 2005.

Xiuqing Wang, Zhongjie Sun, and Robert Cade. Prolonged attenuation of cold-induced hypertension by adenoviral delivery of renin antisense. Kidney Int. 68(2):680-687, 2005.

Xiuqing Wang, Robert Cade, and Zhongjie Sun. Human eNOS gene delivery attenuates cold-induced hypertension.  Am J Physiol Heart & Cir Physiol. 289(3):H1161-1168, 2005.

Zhongjie Sun, Xiuqing Wang, Charles Wood, and Robert Cade. Genetic AT1A receptor deficiency attenuates cold-induced hypertension.  Am J Physiol Regul Integr Comp Physiol. 288(2):R433-R439, 2005.

Zhongjie Sun and Zhonge Zhang. The major types of experimentally-induced hypertension. Cardiovas. Res & Rev. 24(4):191-196, 2003.

Zhongjie Sun, Zhonge Zhang, and Robert Cade. Renal responses to chronic cold exposure. Can J Physiol Pharmacol. 81(1):22-27, 2003.

Zhongjie Sun, Robert Cade, Zhonge Zhang, James Alouidor, and Huong Van. Angiotensinogen gene knockout delays and attenuates cold-induced hypertension. Hypertension. 41:322-327, 2003.

Zhongjie Sun, Robert Cade, and Cerinda Morales.  Role of central angiotensin II receptors in cold-induced hypertension. Am. J. Hypertens. 15(1):85-92, 2002.

Zhongjie Sun, Robert Cade, and Cheryl Tatum. Central imidazoline and angiotensin II receptors in cardiovascular responses to chronic cold exposure in rats.  J. Thermal Biol. 26:513-518, 2001.

Zhongjie Sun and Robert Cade. Cold-induced hypertension and diuresis. J. Therm. Biol. 25:105-109, 2000.

Shechtman, O., Zhongjie Sun, M.J. Fregly and M.J. Katovich. Increased tail artery vascular responsiveness to angiotensin II in cold-treated rats. Can. J. Physiol. Pharmacol. 77(12):974-979, 1999. 

Zhongjie Sun, Robert Cade, Michael Katovich, and Melvin Fregly. Body fluid distribution in rats with Cold-induced hypertension. Physiol. Behav. 65(4/5):879-884, 1999.

Zhongjie Sun, Robert Cade, Melvin Fregly, and Neil Rowland. Effect of chronic treatment with propranolol on the cardiovascular responses to cold. Physiol. Behav. 62(2):379-384, 1997.

Zhongjie Sun, Robert Cade & Melvin Fregly. Cold-induced hypertension: A model of mineralocorticoid-induced hypertension. Ann. NY. Acad. Sci. 813:682-688, 1997.

Zhongjie Sun, Melvin J. Fregly, and Neil E. Rowland. Comparison of changes in blood pressure and dipsogenic responsiveness in male and female rats chronically exposed to cold. Physiol. Behav. 60(6):1543-1549, 1996.

Zhongjie Sun, J. Robert Cade and Melvin J. Fregly. Effect of renal denervation on the elevation of blood pressure in cold exposed rats. Can. J. Physiol. Pharmacol. 73:72-78, 1995.

Melvin J. Fregly, Zhongjie Sun and J. Robert Cade. Effect of a non-peptide angiotensin II receptor antagonist on the elevated blood pressure of cold-exposed rats. Thermal Balance in Health and Disease. Advances in Pharmacological Sciences. Birkhauser Verlag Basel. 455-460, 1994.

Melvin J. Fregly, Fabian Rossi, Zhongjie Sun, Nihal Tumer, Robert Cade, Donald Hegland, and M Yurekli.  Effect of chronic treatment with prazosin and L-arginine on the elevation of blood pressure during cold exposure. Pharmacology. 49(6):351-362, 1994.

Zhongjie Sun, Peng Li, and Yoshiaki Hayashida. Inhibitory effect of morphine on cardiovascular responses and renal sympathetic nerve activity induced by tail stimulation in conscious unrestrained rats. Chin J Physiol Sci. 8(4):326-332, 1992.

Autism Research

Zhongjie Sun and Robert Cade.  A finding in normal rats following administration of Gliadorphin-7 (GD-7). Peptides. 24(2):321-323, 2003.

Zhongjie Sun, Robert Cade, Zaher Elmir and Melvin J. Fregly. Possible relation of β-casomorphin to apnea in sudden infant death syndrome. Peptides. 24(6):937-943, 2003.

Robert Cade, Malcolm Privette, Melvin Fregly, Neil Rowland, Zhongjie Sun, Virgina Zele, Herbert Wagemaker, and Charlotte Edelstein. Autism and schizophrenia: Intestinal diseases. Nutritional Neuroscience 3:57-72, 2000.

Zhongjie Sun and Robert Cade. A peptide found in schizophrenia and autism causes behavioral changes in rats. Autism. 3(1):85-95, 1999.

Zhongjie Sun, J. Robert Cade, Melvin J. Fregly, and Malcolm Privette.  β-Casomorphin induces Fos-like immunoreactivity in discrete brain regions relevant to schizophrenia and autism. Autism. 3(1):67-83, 1999.

Zhongjie Sun and Robert Cade. β-Casomorphin, schizophrenia, and autism. Proceedings of the 2nd Pan-Asia Pacific Conference on Mental Health. 2:575-583, 1998.

Robert Cade and Zhongjie Sun. Autism and Schizophrenia. Proceedings of the 2nd Pan-Asia Pacific Conference on Mental Health. 2:96-103, 1998.