Education:
Postgraduate Education
2018. Ph.D. in Theoretical Medicine, Summa Cum Laude. University of Szeged, Szeged, Hungary; Advisor: Dr. Istvan Krizbai
2012. M.Sc. in NEUROBIOLOGY. University of Szeged, Szeged, Hungary.
2010. B.Sc. in BIOLOGY. University of Szeged, Szeged, Hungary.
Postgraduate Training
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2014 - 2015
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Scientific administrator, Institute of Biophysics, BRC, Szeged
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2017 - 2019
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Junior research associate, Institute of Biophysics, BRC, Szeged
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2019 - 2020
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Research Scholar, Reynolds Oklahoma Center on Aging, OUHSC, Oklahoma City, OK
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2020 - 2022
2022 -
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Postdoctoral Fellow, Department of Biochemistry and Molecular Biology, Center for Geroscience and Healthy Brain Aging, OUHSC, Oklahoma City, OK
Postdoctoral Fellow, Vascular Cognitive Impairment and Neurodegeneration and Healthy Brain Aging Program, Department of Neurosurgery, OUHSC, Oklahoma City, OK
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Fellowship:
2021-2023. Postdoctoral Fellowship, American Heart Association
Clinical/Research Interests:
My long-term research interest is to achieve a more comprehensive understanding of microvascular physiological and pathological mechanisms especially inflammation and aging and to develop new strategies for treatment of different age-related diseases, like Vascular Cognitive Impairment (VCID).
Select Honors & Accomplishments:
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2010
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1st prize in Physiology II. session, Student Research Conference, Szeged, Hungary
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2012
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3rd prize of József Sófi for the Talents of Szeged Foundation, M.Sc. category
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2014
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Session winner prize, in Session of Biological Sciences at „Tavaszi Szél” Conference, Debrecen, Hungary
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2015
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Gedeon Richter Centenary Foundation Scholarship
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2016
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1st prize of József Sófi for the Talents of Szeged Foundation, Ph.D. category
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2016
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SZTE Talent Scholarship, and membership of the „List of Excellence” of University of Szeged in Ph.D. category
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2016
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Speaker Award, Conference of the Hungarian Pharmacology, Anatomy, Microcirculation and Physiological Societies, Pécs, Hungary
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2016
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National Excellence Scholarship, Doctoral Category, New National Excellence Program of the Ministry of Human Capacities, ÚNKP-16-3, Hungarian Government
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2016
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Best poster prize, on 19th International Symposium on Signal Transduction at the Blood-Brain Barrier, Coppenhagen, Denmark
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2017
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1st prize of József Sófi for the Talents of Szeged Foundation, Ph.D. category
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2017
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Gedeon Richter Centenary Foundation Scholarship
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2017
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SZTE Talent Scholarship, and membership of the „List of Excellence” of University of Szeged in Ph.D. category
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2018
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Dr. Joó Ferenc Prize, Dr. Joó Ferenc Foundation for Brain Research, Szeged Hungary
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2019
2020
2021
2022
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„Qualitas Biologica” Prize in Ph.D. thesis category „Qualitas Biologica” Foundation, Szeged, Hungary
Microcirculatory Society Poster Award on Vascular Biology 2020, NAVBO online, USA
Microcirculatory Society Poster Award on Experimental Biology 2021, online, USA
Paul F. Glenn Award, 1st Place, American Aging Association, San Antonio, Tx, USA
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Select Publications:
Cell non-autonomous regulation of cerebrovascular aging processes by the somatotropic axis.
Bickel MA, Csik B, Gulej R, Ungvari A, Nyul-Toth A, Conley SM. Front Endocrinol (Lausanne). 2023 Jan 23;14:1087053. doi: 10.3389/fendo.2023.1087053. eCollection 2023. PMID: 36755922
Old blood from heterochronic parabionts accelerates vascular aging in young mice: transcriptomic signature of pathologic smooth muscle remodeling.
Kiss T, Nyúl-Tóth Á, Gulej R, Tarantini S, Csipo T, Mukli P, Ungvari A, Balasubramanian P, Yabluchanskiy A, Benyo Z, Conley SM, Wren JD, Garman L, Huffman DM, Csiszar A, Ungvari Z. Geroscience. 2022 Apr;44(2):953-981. doi: 10.1007/s11357-022-00519-1. Epub 2022 Feb 5. PMID: 35124764
Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain.
Kiss T, Nyúl-Tóth Á, DelFavero J, Balasubramanian P, Tarantini S, Faakye J, Gulej R, Ahire C, Ungvari A, Yabluchanskiy A, Wiley G, Garman L, Ungvari Z, Csiszar A. Geroscience. 2022 Apr;44(2):661-681. doi: 10.1007/s11357-022-00521-7. Epub 2022 Jan 31. PMID: 35098444
Cerebral venous congestion exacerbates cerebral microhemorrhages in mice.
Nyul-Toth A, Fulop GA, Tarantini S, Kiss T, Ahire C, Faakye JA, Ungvari A, Toth P, Toth A, Csiszar A, Ungvari Z. Geroscience. 2022 Apr;44(2):805-816. doi: 10.1007/s11357-021-00504-0. Epub 2022 Jan 6. PMID: 34989944
Early manifestation of gait alterations in the Tg2576 mouse model of Alzheimer's disease.
Nyul-Toth A, DelFavero J, Mukli P, Tarantini A, Ungvari A, Yabluchanskiy A, Csiszar A, Ungvari Z, Tarantini S. Geroscience. 2021 Aug;43(4):1947-1957. doi: 10.1007/s11357-021-00401-6. Epub 2021 Jun 23. PMID: 34160781
Demonstration of age-related blood-brain barrier disruption and cerebromicrovascular rarefaction in mice by longitudinal intravital two-photon microscopy and optical coherence tomography.
Nyúl-Tóth Á, Tarantini S, DelFavero J, Yan F, Balasubramanian P, Yabluchanskiy A, Ahire C, Kiss T, Csipo T, Lipecz A, Farkas AE, Wilhelm I, Krizbai IA, Tang Q, Csiszar A, Ungvari Z. Am J Physiol Heart Circ Physiol. 2021 Apr 1;320(4):H1370-H1392. doi: 10.1152/ajpheart.00709.2020. Epub 2021 Feb 5. PMID: 33543687
Increases in hypertension-induced cerebral microhemorrhages exacerbate gait dysfunction in a mouse model of Alzheimer's disease.
Nyúl-Tóth Á, Tarantini S, Kiss T, Toth P, Galvan V, Tarantini A, Yabluchanskiy A, Csiszar A, Ungvari Z. Geroscience. 2020 Dec;42(6):1685-1698. doi: 10.1007/s11357-020-00256-3. Epub 2020 Aug 25. PMID: 32844283
Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain.
Kiss T, Nyúl-Tóth Á, Balasubramanian P, Tarantini S, Ahire C, DelFavero J, Yabluchanskiy A, Csipo T, Farkas E, Wiley G, Garman L, Csiszar A, Ungvari Z. Geroscience. 2020 Apr;42(2):429-444. doi: 10.1007/s11357-020-00177-1. Epub 2020 Mar 31. PMID: 32236824
Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects.
Kiss T, Nyúl-Tóth Á, Balasubramanian P, Tarantini S, Ahire C, Yabluchanskiy A, Csipo T, Farkas E, Wren JD, Garman L, Csiszar A, Ungvari Z. Geroscience. 2020 Apr;42(2):527-546. doi: 10.1007/s11357-020-00165-5. Epub 2020 Feb 13. PMID: 32056076
Role of pattern recognition receptors of the neurovascular unit in inflamm-aging.
Wilhelm I, Nyúl-Tóth Á, Kozma M, Farkas AE, Krizbai IA. Am J Physiol Heart Circ Physiol. 2017 Nov 1;313(5):H1000-H1012. doi: 10.1152/ajpheart.00106.2017. Epub 2017 Aug 11. PMID: 28801521
Expression of pattern recognition receptors and activation of the non-canonical inflammasome pathway in brain pericytes.
Nyúl-Tóth Á, Kozma M, Nagyőszi P, Nagy K, Fazakas C, Haskó J, Molnár K, Farkas AE, Végh AG, Váró G, Galajda P, Wilhelm I, Krizbai IA. Brain Behav Immun. 2017 Aug;64:220-231. doi: 10.1016/j.bbi.2017.04.010. Epub 2017 Apr 18. PMID: 28432035
Heterogeneity of the blood-brain barrier.
Wilhelm I, Nyúl-Tóth Á, Suciu M, Hermenean A, Krizbai IA. Tissue Barriers. 2016 Jan 28;4(1):e1143544. doi: 10.1080/21688370.2016.1143544. eCollection 2016 Jan-Mar. PMID: 27141424
Differences in the molecular structure of the blood-brain barrier in the cerebral cortex and white matter: an in silico, in vitro, and ex vivo study.
Nyúl-Tóth Á, Suciu M, Molnár J, Fazakas C, Haskó J, Herman H, Farkas AE, Kaszaki J, Hermenean A, Wilhelm I, Krizbai IA. Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1702-14. doi: 10.1152/ajpheart.00774.2015. Epub 2016 Apr 8. PMID: 27059078