OU Medical Center is the only comprehensive academic hospital in the state and is home to Oklahoma’s only Level I trauma center. OU Medical Center offers the highest level of care for stroke patients and is home to Oklahoma’s most experienced organ transplant team, only comprehensive bone marrow transplant center, and more radiation therapy options than any hospital in Oklahoma. Residents are exposed to a wide variety of patients and pathologies. Most of the inpatient ward, cardiovascular critical care, medical intensive care, and subspecialty consult experiences happen at OU Medical center. Additionally, a new state-of-the-art bed tower with additional inpatient beds, ICUs, and operating rooms opened in 2020. OU Medical Center was ranked in Becker's "Top 100 Hospitals" (2020). 

The Veterans Affairs Medical Center (VAMC) is located directly across the street from the main campus and is connected to the OU Medical Center, Children's Hospital, and Andrews Academic Tower via a skybridge. Internal Medicine residents complete both core months (medical intensive care and inpatient wards) as well as elective rotations in all of the subspecialties at the VAMC. In addition, many of the subspecialty faculty members hold dual accreditation at OU Medical Center as well as VAMC. 

The Nicholson Tower is home to the merged internal medicine resident and attending continuity clinic as well as several subspecialty clinics including dermatology, senior health, rheumatology, gastroenterology, and nephrology. Residents will spend eight half-days in the continuity clinic during their outpatient 2-week Y block rotations. Nicholson Tower additionally has its own radiology department, laboratory, and pharmacy.

The College of Medicine Building (also called the Andrews Academic Tower) is home to the administrative and physician offices of almost all of the subspecialties represented on campus including the Department of Internal Medicine. This modern nine story building built in 2016 is located in a central location on the Health Sciences campus and is walking distance from the OU Medical Center and the VA Medical Center. The Internal Medicine educational conferences are also held at this location. 

In 2019, OU Medical Center and Stephenson earned a highly coveted US News and World Report Top 50 “Best Hospitals for Cancer” ranking, placing it in the Top 1% of all hospitals in the nation for cancer care. Stephenson Cancer Center supports 135 member investigators who conduct state-of-the-art research in the basic, clinical, behavioral and population sciences on the OU Health Sciences Center and OU Norman campuses. Residents have the opportunity to work closely with clinical and research faculty at the Stephenson Cancer Center throughout their training. 

Harold Hamm Diabetes Center is among the world’s largest and most comprehensive institutions focusing on all aspects of diabetes care, prevention, research, and training. Harold Hamm has facilities in Oklahoma City and Tulsa as well as affiliated sites across the state, including partnerships with Native American communities. Hamm Diabetes Center's research group is one of the top-funded and largest in the world. Endocrinologists based out of Harold Hamm also staff an inpatient consult service and dedicate time to teaching residents throughout their training.

OU is home to the state's most comprehensive children’s hospital. The Children’s Hospital also houses the Women’s and Newborn center where internal medicine residents may be called to help manage expectant mothers with various medical conditions. Residents also utilize the ample conference space in the Samis Education Center, located in the Children’s Hospital

The Oklahoma Medical Research Foundation (OMRF) is a non-profit organization that was founded in 1946 with the mission of conducting basic biomedical research to help people live longer, healthier lives. Scientists at OMRF are dedicated to understanding and curing human disease and focus on such critical research areas as lupus, multiple sclerosis, heart disease, cancer, and Alzheimer's disease. Many of the subspecialty attendings and residents hold positions at OMRF and the VA and/or OUMC.