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Wei-Qun Ding, PhD
Pathology

Wei-Qun Ding, PhD

Professor of Experimental Pathology 
Research/Molecular Oncology


Biomedical Sciences Center
940 Stanton L. Young Blvd
RM 401A
Oklahoma City, OK 73104-5020

405-271-1605

weiqun-ding@ouhsc.edu


Academic Section(s):

Pathology


Education:

  • Lund University
    Department of Medical Neurochemistry
    Lund, Sweden
    PhD (1998)
  • Center for Basic Research in Digestive Diseases
    Mayo Clinic and Foundation
    Postdoctoral research fellow (2002)


Clinical/Research Interests:

  • Exosomal signaling in tumor microenvironment
  • Plasma exosomal signatures as non-invasive biomarkers for cancer
  • microRNAs in cancer
  • Anticancer activity of metal binding compounds and docosahexaenoic acid


Select Publications:

 

  1. Xu X, Bhandari K, Xu C, Morris K, Ding WQ. miR-18a and miR-106a signatures in plasma small EVs are promising biomarkers for early detection of pancreatic ductal adenocarcinoma. Int J Mol Sci. 2023 Apr 13;24(8):7215. PMID: 37108374
  2. Xu YF, Xu X, Gin A, Nshimiyimana JD, Mooers BHM, Caputi M, Hannafon BN, Ding WQ. SRSF1 regulates exosome microRNA enrichment in human cancer cells. Cell Commun Signal. 2020 Aug 20;18(1):130. PMID: 32819370.
  3. Xu YF, Hannafon BN, Khatri U, Gin A, Ding WQ. The origin of exosomal miR-1246 in human cancer cells. RNA Biol. 2019 Jun;16(6):770-784. PMID: 30806147.
  4. Hannafon BN, Trigoso YD, Calloway CL, Zhao YD, Lum DH, Welm AL, Zhao ZJ, Blick KE, Dooley WC, Ding WQ. Plasma exosome microRNAs are indicative of breast cancer. Breast Cancer Res. 2016 Sep 8;18(1):90. PMID: 27608715.
  5. Hannafon BN, Carpenter KJ, Berry WL, Janknecht R, Dooley WC, Ding WQ. Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA). Mol Cancer. 2015 Jul 16;14:133. PMID: 26178901.
  6. Zhang S, Xue J, Zheng J, Wang S, Zhou J, Jiao Y, Geng Y, Wu J, Hannafon BN, Ding WQ. The superoxide dismutase 1 3'UTR maintains high expression of the SOD1 gene in cancer cells: The involvement of the RNA-binding protein AUF-1. Free Radic Biol Med. 2015 Aug;85:33-44. PMID: 25908445.
  7. Xue J, Moyer A, Peng B, Wu J, Hannafon BN, Ding WQ.
    Chloroquine is a zinc ionophore. PLoS One. 2014 Oct 1;9(10):e109180. PMID: 25271834.
  8. Hannafon BN, Ding WQ. Intercellular communication by exosome-derived microRNAs in cancer. Int J Mol Sci. 2013 Jul 9;14(7):14240-69. PMID: 23839094. 
  9. Zhou J, Zhang S, Xue J, Avery J, Wu J, Lind SE, Ding WQ. Activation of peroxisome proliferator-activated receptor α (PPARα) suppresses hypoxia-inducible factor-1α (HIF-1α) signaling in cancer cells. J Biol Chem. 2012 Oct 12;287(42):35161-35169. PMID: 22932900.
  10. Jiang H, Taggart JE, Zhang X, Benbrook DM, Lind SE, Ding WQ. Nitroxoline (8-hydroxy-5-nitroquinoline) is more a potent anti-cancer agent than clioquinol (5-chloro-7-iodo-8-quinoline). Cancer Lett. 2011 Dec 15;312(1):11-7.  PMID: 21899946.

Complete List of Published Work:

https://www.ncbi.nlm.nih.gov/myncbi/wei-qun.ding.1/bibliography/public/