Faculty

940 Stanton L. Young Blvd
BMSB 401
Oklahoma City, OK 73104

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Education:

• BS - Biochemistry/Chemistry, Jilin University, Changchun, China (1979-1984)
• PhD - Biochemistry/Biophysics, Oregon State University, Corvallis, OR (1985-1990)

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Fellowship:

• Postdoctoral Fellow, Biochemistry, University of Washington, Seattle, WA (1990-1994)

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Clinical/Research Interests:

• protein tyrosine phosphatases in signal transduction
• hematopoiesis and hematologic cancers
• kinases and phosphatases in cancer, diabetes, and aging

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Select Publications:

1. Bello S, Krogsbøll LT, Gruber J, Zhao ZJ, Fischer D, Hróbjartsson A. Lack of blinding of outcome assessors in animal model experiments implies risk of observer bias. J Clin Epidemiol. 2014 Jun 24. pii: S0895-4356(14)00157-7. doi: 10.1016/j.jclinepi.2014.04.008. PMID: 24972762.  
2. Cherry M, Khawandanah M, Zhao ZJ, Srour S, Ozer H, Selby G, Ghabache B, Al-Kali A. Erlotinib is not effective in patients with JAK2V617F-positive polycythemia vera. [Letter to the Editor] Ann Hematol. Epub 2014 Nov 9. doi: 10.1007/s00277-014-2247-1. PMID: 25380996.
3. Jin X, Zhao W, Kirabo A, Park SO, Ho WT, Sayeski PP, Zhao ZJ. Elevated levels of mast cells are involved in pruritus associated with polycythemia vera in JAK2V617F transgenic mice. J Immunol. 2014 Jul 15;193(2):477-84. doi: 10.4049/jimmunol.1301946. Epub 2014 Jun 11.  PMID: 24920845.
4. Zhao BF, Zhao ZJ. Molecular cloning and characterization of a tyrosine phosphatase from Monosiga brevicollis. Send to: Biochem Biophys Res Commun. 2014 Oct 31;453(4):761-6. doi: 10.1016/j.bbrc.2014.10.019. Epub 2014 Oct 13. PMID: 25445586.
5. Zhao W, Zou K, Farasyn T, Ho WT, Zhao ZJ. Generation and characterization of a JAK2V617F-containing erythroleukemia cell line. PLoS One. 2014 Jul 18;9(7):e99017. PMID: 25036984.  
6. Zhao ZJ, Liu D. A new Stem Cell Investigation. [Editorial] Stem Cell Invest. 2014, 1:1 (2014 Jan 17). (Journal not currently indexed for Medline)  
7. Agarwal A, Morrone K, Bartenstein M, Zhao ZJ, Verma A, Goel S. Bone marrow fibrosis in primary myelofibrosis: pathogenic mechanisms and the role of TGF-β. Stem Cell Investig. 2016 Feb 26;3:5. doi: 10.3978/j.issn.2306-9759.2016.02.03. eCollection 2016. PMID: 27358897; PubMed Central PMCID: PMC4923632.
8. Chen Y, Guo Y, Zhao W, Tina Ho WT, Fu X, Zhao ZJ. Identification of an orally available compound with potent and broad FLT3 inhibition activity. Oncogene. 2016 Jun 9;35(23):2971-8. doi: 10.1038/onc.2015.362. Epub 2015 Sep 28. PMID: 26411368; PMCID: PMC4809803.
9. Guo Y, Fu X, Huo B, Wang Y, Sun J, Meng L, Hao T, Zhao ZJ, Hu X. GATA2 regulates GATA1 expression through LSD1-mediated histone modification. Am J Transl Res. 2016 May 15;8(5):2265-74. eCollection 2016. PMID: 27347333; PMCID: PMC4891438.
10. Shen T, Chen Z, Zhao ZJ, Wu J. Genetic defects of the IRF1-mediated major histocompatibility complex class I antigen presentation pathway occur prevalently in the JAK2 gene in non-small cell lung cancer. Oncotarget. Epub 2017 May 8. doi: 10.18632/oncotarget.17689. PMID: 28537924