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Molecular Genetics
and Genome Sciences

Unlocking the Code of Life — Advancing Health Through Genomic Discovery

At the University of Oklahoma College of Medicine, the Department of Molecular Genetics and Genome Sciences is forging a bold new path in biomedical research. As one of the newest basic science departments at OU Health Sciences, we are dedicated to exploring the fundamental building blocks of life, and transforming that knowledge into real-world solutions that improve human health.

The genome, our complete set of DNA, holds the key to understanding nearly every disease. By examining how genetic variations and epigenetic regulation drive development, normal function, and disease processes, genome research is poised to open new frontiers of discovery. From cancer genetics to AI-powered drug discovery, from single-cell sequencing to multi-omic integration, our research aims to span the full spectrum of contemporary genomic science.

A New Hub for Discovery and Collaboration

Under the leadership of Dr. Jun Li, a nationally recognized genome scientist and computational biologist, the department has begun to bring together an exceptional community of scientists to drive research that changes lives. Dr. Li’s arrival from the University of Michigan Medical School marks a new era of interdisciplinary innovation and national collaboration at the University of Oklahoma. His team’s work, often integrating large-scale biological data with advanced computational methods, has already shed light on complex conditions ranging from metabolic disorders to reproductive health.

The department serves as a critical pillar in OU’s strategic plan to become a top-tier public research university and an Association of American Universities (AAU) member. As one of the fastest-growing areas in biomedical science, genetics is central to the future of precision medicine, and this department ensures OU is not only participating, but leading, in this revolution.

To jump-start its fast growth, the Department of Molecular Genetics and Genome Sciences is among the first to occupy newly renovated lab space at University Research Park  in Oklahoma City. As part of a $55 million investment in research infrastructure, this cutting-edge facility features open-concept labs, advanced microscopy and cell culture suites, ultra-low temperature storage, and specialized instrumentation, all designed to foster high-impact, team-based science. Shared collaboration zones and flexible, state-of-the-art workspaces bring together researchers, clinicians, and students from across disciplines, creating an environment that accelerates discovery, attracts top-tier talent, and drives innovation at the intersection of genetics, genomics, and human health.

Training the Next Generation of Scientists

As we build up our research and collaboration portfolio, we are also launching robust training programs to equip the next generation of geneticists and biomedical researchers. New master’s and Ph.D. programs will offer immersive, mentored research experiences in a collaborative academic health center environment. Whether decoding inherited diseases, mapping gene function in tissues, or exploring the epigenetic consequences of lifestyle and environment, students in our programs will be part of a transformative mission to advance science and serve society.

Shaping the Future of Medicine

With strong support from the OU Board of Regents and the broader research community, the Department of Molecular Genetics and Genome Sciences is more than a new academic unit—it is a powerful engine of discovery, education, and clinical translation. As we build this department from the ground up, we invite researchers, students, and collaborators to join us in redefining what’s possible in medicine and human health.