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OU College of Medicine

#1 Research University

In the State of Oklahoma

Funding

$177 Million in Total Sponsored Funding
$72 Million in NIH Funding

Rankings

4 Departments Ranked Top 25 
12 Departments Ranked Nationally 
By Blue Ridge Institute for Medical Research

300+

Active Clinical Trials

It’s an exciting time at the University of Oklahoma College of Medicine. The college is making major, strategic investments to accelerate health research in key areas and to recruit exceptional scientific talent from around the world. As we expand our research enterprise, we are committed to driving discoveries that improve health outcomes, deepen scientific understanding, and strengthen the future of healthcare in Oklahoma and beyond.

A cornerstone of this momentum is Project 200, a bold initiative within the University of Oklahoma’s strategic plan to recruit the nation’s top researchers—innovators whose breakthroughs will change and save lives, fuel Oklahoma’s economy, and elevate OU among the country’s most impactful research institutions. 

Learn More About Project 200 Join OU Research

Areas of Focus

Through five basic science departments across academic medicine, faculty conduct foundational, clinical, and translational research that moves ideas from bench to bedside.

Our teams are advancing discovery across the cancer continuum—uncovering risk factors, improving early detection, and developing next-generation immunotherapies and personalized treatments that transform patient outcomes.

neuroscience

From neurodegenerative disease to brain–AI interfaces, our scientists are decoding brain function, developing precision approaches to neurological care, and pioneering technologies that restore or enhance neural health.

We offer many promising research-based treatments are part of our seamless care. See information for accessing clinical trials being conducted in each area of our practice.

Researchers are tackling diabetes and obesity at their roots, exploring metabolic pathways, genomic risk, therapeutic innovation, and interventions that prevent complications and improve long-term health.

Chronic Disease, Population Health & Health Services

Teams explore how biology, behavior, environment, and policy drive chronic disease—advancing solutions that reduce disparities, improve care delivery, and move communities toward better health.

An Environment Built for Breakthroughs

The College of Medicine is supported by state-of-the-art laboratory spaces designed to advance discovery and collaboration. Recent investments include more than 29,100 square feet of new laboratory space at University Research Park, part of a $55 million commitment to strengthening OU’s research infrastructure. Open-concept labs, advanced microscopy and cell culture suites, and shared collaboration areas support high-impact, team-based science and translational research.

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Research Resources

Find the resources you need to advance research at the OU College of Medicine, including regulatory support, core facilities, research centers, grant tools, and opportunities for students and trainees.

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OU researcher’s discoveries could help predict unknown drug interactions

OU researcher’s discoveries could help predict unknown drug interactions

A University of Oklahoma researcher has received a $1.9 million National Institutes of Health award to uncover new ways to predict when multiple medications taken together could cause dangerous side effects.
Weight-Loss Surgery Produces Lasting Diabetes Remission, Long-Term Study Finds

Weight-Loss Surgery Produces Lasting Diabetes Remission, Long-Term Study Finds

People with type 2 diabetes were much more likely to achieve remission after weight-loss surgery than after intensive medical and lifestyle management, according to a long-term study. Researchers also identified patient characteristics linked to remission and to the likelihood of diabetes...
OU College of Nursing receives millions to advance maternal health research

OU College of Nursing receives millions to advance maternal health research

The University of Oklahoma’s Fran and Earl Ziegler College of Nursing has received over $5 million in additional funding through a National Institutes of Health initiative to support four maternal health research projects over the next four years.
OU Researcher to Study CAR T-Cell and Opaganib Combination in Clinical Trials for Ultra-High-Risk Multiple Myeloma

OU Researcher to Study CAR T-Cell and Opaganib Combination in Clinical Trials for Ultra-High-Risk Multiple Myeloma

Patients with ultra-high-risk multiple myeloma, an aggressive form of blood cancer, often respond poorly to standard treatments, including bone marrow transplant. A University of Oklahoma physician-researcher recently received $2.9 million in funding from the National Cancer Institute to study...
OU Diabetes Researcher Identifies Potential New Target for Type 2 Diabetes

OU Diabetes Researcher Identifies Potential New Target for Type 2 Diabetes

A protein called Miro1 found at elevated levels in the skeletal muscle of people with type 2 diabetes may contribute to insulin resistance, potentially making it a target for future treatments that help the body regulate blood sugar, according to a study published today in Nature Communications....
OU mHealth Project Aims to Address Native Americans’ Pain Disparity

OU mHealth Project Aims to Address Native Americans’ Pain Disparity

Nearly one in three Native Americans live with chronic pain, more than any other segment of the U.S. population. But providing in-person relief has long been complicated by financial and geographic barriers. A University of Oklahoma mHealth initiative seeks to reduce this pain imbalance.
OU Researchers Develop Digital Program to Help Oklahomans Prevent Diabetes

OU Researchers Develop Digital Program to Help Oklahomans Prevent Diabetes

One in eight Oklahomans has type 2 diabetes, and an estimated one-third of the state’s adult population has undiagnosed prediabetes. University of Oklahoma researchers are developing a digital outreach program to help people understand their risk and connect with resources to help prevent...
OU College of Medicine researcher named 2026 AAIP Physician of the Year

OU College of Medicine researcher named 2026 AAIP Physician of the Year

A leader in improving Native American health outcomes, Dorothy A. Rhoades, M.D., M.P.H., has been named the 2026 Physician of the Year by the Association of American Indian Physicians (AAIP).
Residents Honored With Lloyd Rader Award

Residents Honored With Lloyd Rader Award

The University of Oklahoma College of Medicine has honored two residents with the Lloyd Rader Award, which recognizes outstanding clinical and research achievements in residency. Named for the director of the Oklahoma Department of Human Services from 1951 to 1982, the award comes with a $500...
OU Study Tests Peer Mentoring to Help Young Adults Quit Vaping

OU Study Tests Peer Mentoring to Help Young Adults Quit Vaping

Young adults who want to quit vaping may turn to social media for support, but keeping them engaged with digital cessation programs over time can be challenging. A University of Oklahoma researcher is testing whether adding support from trained peers can help keep young adults engaged as they try...
OU Study Examines Whether Blood Tests Can Detect Cancer

OU Study Examines Whether Blood Tests Can Detect Cancer

At OU Health Stephenson Cancer Center at the University of Oklahoma, enrollment is underway for the Vanguard Study, which is evaluating whether multi-cancer detection tests can find cancer at an earlier stage than is currently possible.
Cell Paper Identifies Subclusters Driving Cancer-Induced Cachexia

Cell Paper Identifies Subclusters Driving Cancer-Induced Cachexia

Research published today in Cell identifies three small subclusters of cells driving pancreatic cancer-induced cachexia, a muscle-wasting and fat-loss condition that makes patients less tolerant of cancer treatment. The study, led by the University of Oklahoma, holds significant promise for the...
A Game Changer: Harold Hamm commits largest gift in OU history to lift health of Oklahoma, name Health Campus

A Game Changer: Harold Hamm commits largest gift in OU history to lift health of Oklahoma, name Health Campus

The University of Oklahoma today announced an historic $150 million gift from Harold Hamm, the largest single gift in university history, to lift the health of Oklahoma by advancing health education, research and discovery, strengthening the state’s health care workforce and accelerating...
Li Named President of International Association of Pancreatology

Li Named President of International Association of Pancreatology

Min Li, Ph.D., George Lynn Cross Research Professor of Medicine, Surgery and Cell Biology at the University of Oklahoma College of Medicine and Associate Director for Global Oncology at OU Health Stephenson Cancer Center, has been named president of the International Association of Pancreatology...
OU Health Campus Explores AI’s Potential to Improve Health in Oklahoma

OU Health Campus Explores AI’s Potential to Improve Health in Oklahoma

Artificial intelligence is rapidly changing healthcare, research and education, creating new opportunities to improve the health of Oklahomans while also raising important questions about its risks and responsible use. Those opportunities and challenges took center stage at the first AI Symposium...
Siddhartha Mukherjee discusses AI and health at OU Presidential Speakers Series dinner

Siddhartha Mukherjee discusses AI and health at OU Presidential Speakers Series dinner

The University of Oklahoma welcomed Siddhartha Mukherjee to campus for the Presidential Speakers Series dinner on the evening of Sept. 9 at the Oklahoma Memorial Union. Mukherjee — an oncologist, entrepreneur and Pulitzer Prize-winning author — delivered a talk titled “Research...
Protein Linked to Cell Death May Also Drive Liver Cancer

Protein Linked to Cell Death May Also Drive Liver Cancer

New research from the University of Oklahoma identifies a protein in liver cells that appears to help drive the development of liver cancer associated with obesity-related fatty liver disease. The finding, published in Hepatology, points to the protein as a potential new therapeutic target for...
Study Targets Prostate Cancer Screening Gap Among Black Men

Study Targets Prostate Cancer Screening Gap Among Black Men

A newly funded study at the University of Oklahoma aims to increase prostate-specific antigen (PSA) screening among Black men in Oklahoma, who die from prostate cancer at rates two to four times higher than other racial groups. An interactive app called Connect2Care may hold the key to early...
Study Aims to Empower Parents to Prevent Teen Vaping

Study Aims to Empower Parents to Prevent Teen Vaping

Parents are an important line of defense against teen vaping, yet many lack the knowledge and tools needed to recognize vaping products, understand their risks and prevent their children from using them. A new University of Oklahoma study will examine whether targeted social media messages can...
Researcher Investigates How Mother’s Diet Shapes Liver Health

Researcher Investigates How Mother’s Diet Shapes Liver Health

University of Oklahoma researcher Keenan Greyslak, Ph.D., has long been interested in how a mother’s diet during pregnancy and lactation may influence a child’s risk of developing metabolic diseases earlier and more severely as they age. With a new grant from the National Institutes...