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Faculty and Staff

Faculty

Rajagopal Ramesh, PhD
Pathology

Rajagopal Ramesh, PhD

Jim and Christy Everest Endowed Chair in Cancer Developmental Therapeutics
Professor of Pathology
Director, Experimental Therapeutics and Translational Cancer Medicine
Chair, Fellowship Training and Mentoring Program
Member, OU Cancer Institute


Stephenson Cancer Center 
Stanton L. Young Biomedical Research Center
Suite # 1403
University of Oklahoma Health Sciences Center
975 N.E., 10th Street
Oklahoma City, OK 73104

405-271-6101 Ext: 52501

rajagopal-ramesh@ouhsc.edu


Education:

  • B.Sc. - Biology, Osmania University
    Hyderabad, India, 1985
  • M.Sc - Microbiology
    Osmania University
    Hyderabad, India, 1987
  • DBA 
    Annamalai Univeristy
    Tamil Nadu, India, 1992
  • Ph.D. - Molecular Biology
    All India Institute of Medical Sciences (AIIMS)
    New Delhi, India, 1994


Fellowship:

  • Post-Doctoral Fellow
    Tulane University Medical Center, 
    New Orleans, LA, 1997


Clinical/Research Interests:

Studies in my laboratory are mainly focused on novel gene-based therapeutics using viral and non-viral vectors with emphasis on translational cancer research. There are two major research areas that are actively being pursued in the laboratory. The first research area is the development and testing of non-viral and nanoparticle-based gene delivery for cancer treatment, and the second research area is studying the antitumor and anti-angiogenic properties of IL-24. Our findings have lead to Phase I clinical trials for treatment of solid tumors.


Select Publications:

  1. Srivastava A, Filant J, Moxley KM, Sood A, McMeekin S, Ramesh R. Exosomes: A role for naturally occurring nanovesicles in cancer growth, diagnosis and treatment. Curr Gene Ther. Epub ahead of print 2014 Dec 23. doi: 10.2174/1566523214666141224100612. PMID: 25537774. (Print issue: 2015, Vol 15.)  

  2. Panneerselvam J, Shanker M, Jin J, Branch CD, Muralidharan R, Zhao DY, Chada S, Munshi A, Ramesh R. Phosphorylation of interleukin (IL)-24 is required for its anticancer activity. Oncotarget. 2015 May 18;6(18):16271-16286. PMID: 26009991.

  3. Ha JH, Gomathinayagam R, Yan M, Jayaraman M, Ramesh R, Dhanasekaran DN. Determinant role for the gep oncogenes, Gα12/13, in ovarian cancer cell proliferation and xenograft tumor growth. Genes Cancer. 2015; Advance Publication, 2015 Aug 3.  

  4. Al Mubarak ZH, Ramesh R, Liu L, Krishnan S. Surface plasmon resonance imaging of gold-small molecule interactions is influenced by refractive index and chemical structures. J Colloid Interface Sci. Epub ahead of print 25 Aug 2015;460:209-213. doi: 10.1016/j.jcis.2015.08.059. PMID: 26321574.  

  5. Klionsky DJ, Abdelmoshen K, Abe A, Abdedin MG, Hagai A, Arozena AA, Adachi H, Adams CM, Adams PD, Ramesh R, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. (3rd Edition) Autophagy. 12(1):1-222, ePub 21 Jan 2016. doi:10.1080/15548627.2015.1100356. PMID: 26799652

  6. Yang J, Hannafon BN, Zhang RR, Fung KM, Ding WQ. Docosahexaenoic acid and disulfiram act in concert to kill cancer cells: a mutual enhancement of their anticancer actions. Oncotarget. 2017 Jan 17. doi: 10.18632/oncotarget.14702. [Epub ahead of print] PMID: 28107189

  7. Amreddy N, Babu A, Muralidharan R, Munshi A, Ramesh R. Polymeric nanoparticle-mediated gene delivery for lung cancer treatment. Top Curr Chem (J). 2017 Apr;375(2):35. doi: 10.1007/s41061-017-0128-5 (Epub ahead of print) PMID: 28290155  

  8. Babu A, Ramesh R. Multifaceted applications of chitosan in cancer drug delivery and therapy. Mar Drugs. 2017 Mar 27;15(4). pii: E96. doi: 10.3390/md15040096. PMID: 28346381

  9. Griffith J, Andrade D, Mehta M, Berry W, Benbrook DM, Aravindan N, Herman TS, Ramesh R, Munshi A. Silencing BMI1 radiosensitizes human breast cancer cells by inducing DNA damage and autophagy. Oncol Rep. 2017 Feb 28. doi: 10.3892/or.2017.5478 (Epub ahead of print) PMID: 28260023

  10. Babu A, Munshi A, Ramesh R. Combinatorial therapeutic approaches with RNAi and anticancer drugs using nanodrug delivery systems. Drug Dev Ind Pharm. 2017 May 19:1-11. doi: 10.1080/03639045.2017.1313861. [Epub ahead of print]. PMID: 28523942



Adjunct Faculty

Prabir K. Chakraborty, PhD

Prabir K. Chakraborty, PhD

Assistant Professor (Research)

Daniel J. Cowden, MD, FCAP, CPHIMS

Daniel J. Cowden, MD, FCAP, CPHIMS

Clinical Associate Professor

Charles Esmon, PhD

Charles Esmon, PhD

Lloyd Noble Chair, Cardiovascular Research

Member & Head, Cardiovascular Biology Research at OMRF

Adjunct Professor, Pathology

Adjunct Professor, Biochemistry

Investigator at Howard Hughes Medical Institute

David M Lewis, DDS

David M. Lewis, DDS

Associate Professor
Department of Oral and Maxillofacial Pathology

Adjunct Associate Professor
Department of Pathology

Charles A. Montgomery, DVM, DACVP, DACLAM

Charles A. Montgomery, DVM, DACVP, DACLAM

Adjunct Professor
Department of Pathology
Division of Comparative Medicine

Kathy L. Moser, PhD

Kathy L. Moser, PhD

Associate Member, Arthritis & Immunology Program
OMRF

Adjunct Faculty, Pathology

Aravindan Natarajan

Aravindan Natarajan, MS., MPhil., PhD., CCA.

Associate Professor, Department of Radiation Oncology,
Associate Professor (Adjunct), Department of Anesthesiology,
Associate Professor (Adjunct), Department of Pathology
Course Director, Radiation Biology for Radiation Oncology Residents
Graduate Faculty, College of Medicine
Member, Cancer Biology Program

Amr H. Sawalha, MD

Amr H. Sawalha, MD

Assistant Member
Arthritis and Immunology Research Program

Assistant Professor of Medicine 
Department of Medicine

Staff Physician 
Veteran Affairs Medical Center
Oklahoma City

Adjunct Faculty
Department of Pathology