https://medicine.ouhsc.edu/academic-departments Parent Page: Academic Departments id: 22538 Active Page: Facultyid:23539

Faculty

Prabha Nagareddy, M.Pharm, PhD, FAHA
Internal Medicine

Prabha R Nagareddy, M.Pharm, PhD, FAHA

Professor of Medicine


O'Donoghue Research Building
1122 NE 13th St, Suite 333B
Oklahoma City, OK, 73117

405-271-8001 Ex 44737

Prabhakara-Nagareddy@ouhsc.edu


The research in Nagareddy lab is broadly focused on defining the pathological basis for enhanced atherothrombotic risk to various cardiovascular risk factors such as diabetes, obesity, cigarette smoking, high salt diet, rheumatoid arthritis etc.  We specifically focus on identifying the inflammatory cues/ signaling mediators that interact with hematopoietic stem and progenitor cells in the bone marrow that promote systemic inflammation. Our major emphasis is on innate immune cells, particularly the neutrophils that have the ability not only to instigate inflammation but also facilitate the resolution of inflammation. We have identified certain neutrophil-derived alarmin molecules such as S100A8 and S100A9 that activate the NLRP3 inflammasome to initiate inflammation while also retaining the ability to induce anti-inflammatory signaling mechanisms. We use various animal models, human samples, invitro and ex vivo techniques to address our research questions. Our short-term goal is to validate and repurpose certain FDA-approved agents to target chronic inflammation and improve cardiometabolic outcomes. The long-term goal is to harness the wealth of knowledge from our studies and others to develop novel therapeutic strategies to reduce the overall burden of cardiovascular and cardiometabolic diseases. Our research is supported by both federal (NIH) and foundation grants (AHA).


Academic Section(s):

Cardiovascular Diseases


Education:

1993-1997:  B. Pharm, Bangalore University, Bangalore, India
1999-2011:  M. Pharm, Rajiv Gandhi University of Health Sciences, Bangalore, India
2002-2004:  MSc, University of British Columbia, Vancouver, BC, Canada
2005-2009:  PhD, University of British Columbia, Vancouver, BC, Canada
2009-2012:  Post Doc, Columbia University, New York, NY, USA
2012-2016:  Post Doc, University of Kentucky, Lexington, KY, USA


Board Certification(s):

FPGEC


Clinical/Research Interests:

Cardiovascular Risk Factors (Obesity, Diabetes, Smoking, High Salt Diet, RA etc.) and Aberrant Hematopoiesis
Neutrophils in Myocardial Infarction and Heart Failure
Myelopoiesis and Thrombopoiesis, Inflammation, Inflammasome and DAMPs
Adipose Tissue Inflammation, Insulin Resistance and Diabetes
Platelet Production and Function in Diabetes
Neutrophils in Pancreatic Islets and Beta Cell Loss
High Salt Diet, Th17 Cells, Gut Microbiome, Hematopoiesis and Atherosclerosis
Clonal Hematopoiesis and Atherosclerosis


Funding:

NIH Funding: https://reporter.nih.gov/search/J843ctCXLESirnUXqAuqKg/projects
ORCID: https://orcid.org/0000-0002-0294-641X


Select Honors & Accomplishments:

2020    Elected, Fellow of the American Heart Association, BCVS (FAHA)
2018    Young Investigator Award (Finalist), ISHR, Canada
2017    Kenneth M. Brinkhous Young Investigator Prize in Thrombosis (Finalist), ATVB/PVD, AHA
2015    Dean’s Distinguished Lecture Award, College of Medicine, University of Kentucky (UK)
2015    Outstanding Post-Doctoral Presentation- Gill Heart Institute Cardiovascular Research Day
2015    Young Investigators Award- at American College of Cardiology (Kentucky Chapter)
2015    Outstanding Early Career Award, (Finalist) at BCVS 2015, AHA Scientific Sessions
2015    Irvine H. Page Young Investigator Research Award (Finalist), ATVB/PVD, AHA
2014    Stew Whitman Memorial Award- Cardiovascular Research Day (UK)
2014    Best Research Presentation- Barnstable Brown Obesity and Diabetes Research Day (UK)
2014    CIHR (The Canadian Institutes of Health Research)-ICS Travel Award
2014    Best Poster Presentation, College of Medicine (UK)
2014    Stew Whitman Memorial Award- Cardiovascular Research Day (UK)
2013    Vasculata Scholarship- North American Vascular Biology Organization (NAVBO)
2013    Best Research Presentation- Barnstable Brown Obesity and Diabetes Research Day (UK)
2012    Have a Heart Award- Canadian Cardiovascular Society, Toronto, Canada
2012    CIHR-ICS Travel Award- Young Investigators Forum, Montreal, Canada
2012    Future of Science Fund Scholarship- Keystone Conference, Montana
2011    Young Investigator Award – ATVB Council, AHA, Chicago
2010    Post-Doctoral Research Fellowship from CIHR (3 years), Canada
2010    Early Career Investigator Award, The Kern Aspen Lipid Conference, Aspen, CO
2008   Peter Dresel Award- The IXth World Conference on Clinical Pharmacology & Therapeutics
2008   Graduate Student Travel Award – Canadian Society for Clinical Pharmacology, Canada
2008   Graduate Student Travel Award- Experimental Biology (ASPET)
2007   Subhash C. Verma Prize for best research published article in Pharma. Sciences, UBC, 
2006   Heart and Stroke Foundation Travel Award, Young Investigators Forum, Canada
2006   Doctoral Research Award, Heart and Stroke Foundation of Canada (3 Years)
2006   Doctoral Research Award, Canadian Diabetes Association (3 Years)
2006   Doctoral Research Award, The Michael Smith Foundation for Health Research (3 Years)
2004   The John H McNeill Prize- UBC, Vancouver, Canada
2004   Graduate Research Scholarship in Pharmacy, CIHR and Rx & D (2 Years), Canada


Select Publications:

OUHSC Profile:  https://profiles.ouhsc.edu/display/8464330
Publications: https://pubmed.ncbi.nlm.nih.gov/?term=nagareddy+pr&sort=date
ORCID: https://orcid.org/0000-0002-0294-641X