https://medicine.ouhsc.edu/academic-departments Parent Page: Academic Departments id: 27839 Active Page: Detailsid:27860

Faculty

Dr. Pankaj K. Singh
Oncology Science

Pankaj K. Singh, PhD

Professor and Founding Chairman, Department of Oncology Science

Jim and Christy Everest Chair in Cancer Research

Senior Director of Oncology Science, Stephenson Cancer Center


940 Stanton L. Young Blvd., Oklahoma City, OK  73104

Office: 405.271.8001 x52229

pankaj-singh@ouhsc.edu


Academic Section(s):

Oncology Science


Education:

Ph.D., University of Nebraska Medical Center, Nebraska, USA 

Postdoctoral Training, Salk Institute for Biological Studies, USA 


Clinical/Research Interests:

  • Cancer Metabolism and metabolic alterations in the regulation of chemotherapy and radiotherapy resistance in pancreatic cancer
  • Metabolic regulation of cancer cachexia
  • Nutritional interventions to prevent/revert wasting in cancer patients,
  • Tumor-stromal metabolic interactions
  • Metabolic regulation of stromal and immune microenvironment in pancreatic cancer
  • Metabolic regulation of stemness and cancer metastasis

Keywords
Cancer Metabolism, Signal transduction, chemotherapy resistance, Immunometabolism, Tumor progression and metastasis, Mucins, Sirtuins, Cancer cachexia, Metabolomics, Pancreatic cancer

Currently recruiting new students and trainees


Select Publications:

King RJ, Shukla SK, He C, Vernucci E, Thakur R, Attri KS, Dasgupta A, Chaika NV, Mulder SE, Abrego J, Murthy D, Gunda V, Pacheco CG, Grandgenett PM, Lazenby AJ, Hollingsworth MA, Yu F, Mehla K, Singh PK. CD73 induces GM-CSF/MDSC-mediated suppression of T cells to accelerate pancreatic cancer pathogenesis. Oncogene. 2022 Feb;41(7):971-982. doi: 10.1038/s41388-021-02132-6. Epub 2022 Jan 10. PubMed PMID: 35001076; PubMed Central PMCID: PMC8840971. 

Hu T, Shukla SK, Vernucci E, He C, Wang D, King RJ, Jha K, Siddhanta K, Mullen NJ, Attri KS, Murthy D, Chaika NV, Thakur R, Mulder SE, Pacheco CG, Fu X, High RR, Yu F, Lazenby A, Steegborn C, Lan P, Mehla K, Rotili D, Chaudhary S, Valente S, Tafani M, Mai A, Auwerx J, Verdin E, Tuveson D, Singh PKMetabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression. Gastroenterology. 2021 Nov;161(5):1584-1600. doi: 10.1053/j.gastro.2021.06.045. Epub 2021 Jul 8. PubMed PMID: 34245764; PubMed Central PMCID: PMC8546779. 

Dasgupta A, Shukla SK, Vernucci E, King RJ, Abrego J, Mulder SE, Mullen NJ, Graves G, Buettner K, Thakur R, Murthy D, Attri KS, Wang D, Chaika NV, Pacheco CG, Rai I, Engle DD, Grandgenett PM, Punsoni M, Reames BN, Teoh-Fitzgerald M, Oberley-Deegan R, Yu F, Klute KA, Hollingsworth MA, Zimmerman MC, Mehla K, Sadoshima J, Tuveson DA, Singh PKSIRT1-NOX4 signaling axis regulates cancer cachexia. J Exp Med. 2020 Jul 6;217(7). doi: 10.1084/jem.20190745. PubMed PMID: 32441762; PubMed Central PMCID: PMC7336299. 

Olou AA, King RJ, Yu F, Singh PKMUC1 oncoprotein mitigates ER stress via CDA-mediated reprogramming of pyrimidine metabolism. Oncogene. 2020 Apr;39(16):3381-3395. doi: 10.1038/s41388-020-1225-4. Epub 2020 Feb 26. PubMed PMID: 32103170; PubMed Central PMCID: PMC7165067. 

Li X, Gong W, Wang H, Li T, Attri KS, Lewis RE, Kalil AC, Bhinderwala F, Powers R, Yin G, Herring LE, Asara JM, Lei YL, Yang X, Rodriguez DA, Yang M, Green DR, Singh PK, Wen H. O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3. Immunity. 2019 Mar 19;50(3):576-590.e6. doi: 10.1016/j.immuni.2019.01.007. Epub 2019 Feb 12. PubMed PMID: 30770249; PubMed Central PMCID: PMC6426684. 

Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Matés JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PKMUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 2017 Jul 10;32(1):71-87.e7. doi: 10.1016/j.ccell.2017.06.004. PubMed PMID: 28697344; PubMed Central PMCID: PMC5533091. 

Chaika NV, Gebregiworgis T, Lewallen ME, Purohit V, Radhakrishnan P, Liu X, Zhang B, Mehla K, Brown RB, Caffrey T, Yu F, Johnson KR, Powers R, Hollingsworth MA, Singh PKMUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer. PNAS. 2012 Aug 21;109(34):13787-92. doi: 10.1073/pnas.1203339109. Epub 2012 Aug 6. PubMed PMID: 22869720; PubMed Central PMCID: PMC3427054. 

Bibliography:  https://www.ncbi.nlm.nih.gov/sites/myncbi/pankaj.singh.1/bibliography/42858263/public/?sortby=pubDate&sdirection=descending