Academic Section(s):
Oncology Science
Education:
Ph.D., University of Nebraska Medical Center, Nebraska, USA
Postdoctoral Training, Salk Institute for Biological Studies, USA
Clinical/Research Interests:
- Cancer Metabolism and metabolic alterations in the regulation of chemotherapy and radiotherapy resistance in pancreatic cancer
- Metabolic regulation of cancer cachexia
- Nutritional interventions to prevent/revert wasting in cancer patients,
- Tumor-stromal metabolic interactions
- Metabolic regulation of stromal and immune microenvironment in pancreatic cancer
- Metabolic regulation of stemness and cancer metastasis
Keywords
Cancer Metabolism, Signal transduction, chemotherapy resistance, Immunometabolism, Tumor progression and metastasis, Mucins, Sirtuins, Cancer cachexia, Metabolomics, Pancreatic cancer
Currently recruiting new students and trainees
Select Publications:
Murthy D, Attri KS, Shukla SK, Thakur R, Chaika NV, He C, Wang D, Jha K, Dasgupta A, King RJ, Mulder SE, Souchek J, Gebregiworgis T, Rai V, Patel R, Hu T, Rana S, Kollala SS, Pacheco C, Grandgenett PM, Yu F, Kumar V, Lazenby AJ, Black AR, Ulhannan S, Jain A, Edil BH, Klinkebiel DL, Powers R, Natarajan A, Hollingsworth MA, Mehla K, Ly Q, Chaudhary S, Hwang RF, Wellen KE, Singh PK. Cancer-associated fibroblast-derived acetate promotes pancreatic cancer development by altering polyamine metabolism via the ACSS2-SP1-SAT1 axis. Nat Cell Biol. 2024 Mar 1. doi: 10.1038/s41556-024-01372-4.
Mullen NJ, Singh PK. Nucleotide metabolism: a pan-cancer metabolic dependency. Nat Rev Cancer. 2023 Mar 27:1-20. doi: 10.1038/s41568-023-00557-7. Online ahead of print.PMID: 36973407
King RJ, Shukla SK, He C, Vernucci E, Thakur R, Attri KS, Dasgupta A, Chaika NV, Mulder SE, Abrego J, Murthy D, Gunda V, Pacheco CG, Grandgenett PM, Lazenby AJ, Hollingsworth MA, Yu F, Mehla K, Singh PK. CD73 induces GM-CSF/MDSC-mediated suppression of T cells to accelerate pancreatic cancer pathogenesis. Oncogene. 2022 Feb;41(7):971-982. doi: 10.1038/s41388-021-02132-6. Epub 2022 Jan 10. PubMed PMID: 35001076; PubMed Central PMCID: PMC8840971.
Hu T, Shukla SK, Vernucci E, He C, Wang D, King RJ, Jha K, Siddhanta K, Mullen NJ, Attri KS, Murthy D, Chaika NV, Thakur R, Mulder SE, Pacheco CG, Fu X, High RR, Yu F, Lazenby A, Steegborn C, Lan P, Mehla K, Rotili D, Chaudhary S, Valente S, Tafani M, Mai A, Auwerx J, Verdin E, Tuveson D, Singh PK. Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression. Gastroenterology. 2021 Nov;161(5):1584-1600. doi: 10.1053/j.gastro.2021.06.045. Epub 2021 Jul 8. PubMed PMID: 34245764; PubMed Central PMCID: PMC8546779.
Dasgupta A, Shukla SK, Vernucci E, King RJ, Abrego J, Mulder SE, Mullen NJ, Graves G, Buettner K, Thakur R, Murthy D, Attri KS, Wang D, Chaika NV, Pacheco CG, Rai I, Engle DD, Grandgenett PM, Punsoni M, Reames BN, Teoh-Fitzgerald M, Oberley-Deegan R, Yu F, Klute KA, Hollingsworth MA, Zimmerman MC, Mehla K, Sadoshima J, Tuveson DA, Singh PK. SIRT1-NOX4 signaling axis regulates cancer cachexia. J Exp Med. 2020 Jul 6;217(7). doi: 10.1084/jem.20190745. PubMed PMID: 32441762; PubMed Central PMCID: PMC7336299.
Olou AA, King RJ, Yu F, Singh PK. MUC1 oncoprotein mitigates ER stress via CDA-mediated reprogramming of pyrimidine metabolism. Oncogene. 2020 Apr;39(16):3381-3395. doi: 10.1038/s41388-020-1225-4. Epub 2020 Feb 26. PubMed PMID: 32103170; PubMed Central PMCID: PMC7165067.
Li X, Gong W, Wang H, Li T, Attri KS, Lewis RE, Kalil AC, Bhinderwala F, Powers R, Yin G, Herring LE, Asara JM, Lei YL, Yang X, Rodriguez DA, Yang M, Green DR, Singh PK, Wen H. O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3. Immunity. 2019 Mar 19;50(3):576-590.e6. doi: 10.1016/j.immuni.2019.01.007. Epub 2019 Feb 12. PubMed PMID: 30770249; PubMed Central PMCID: PMC6426684.
Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Matés JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 2017 Jul 10;32(1):71-87.e7. doi: 10.1016/j.ccell.2017.06.004. PubMed PMID: 28697344; PubMed Central PMCID: PMC5533091.
Chaika NV, Gebregiworgis T, Lewallen ME, Purohit V, Radhakrishnan P, Liu X, Zhang B, Mehla K, Brown RB, Caffrey T, Yu F, Johnson KR, Powers R, Hollingsworth MA, Singh PK. MUC1 mucin stabilizes and activates hypoxia-inducible factor 1 alpha to regulate metabolism in pancreatic cancer. PNAS. 2012 Aug 21;109(34):13787-92. doi: 10.1073/pnas.1203339109. Epub 2012 Aug 6. PubMed PMID: 22869720; PubMed Central PMCID: PMC3427054.
Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/pankaj.singh.1/bibliography/public/