Education:
Postdoctoral Fellow, University of California, Los Angeles
PhD., Biomedical Science (Cell, Molecular and Developmental Biology), University of Maine
Clinical/Research Interests:
- Adult and pediatric brain tumors, glioblastoma (GBM)
- Epigenetic mediators of phenotypic plasticity
- Interplay of DNA repair and metabolism in therapeutic resistance
- Vascular-immune crosstalk in GBM immunosuppression
- Develop pre-clinical models, novel molecular therapeutics and immunotherapy for GBM
Select Publications:
Muthukrishnan SD, Kawaguchi R, Nair P, Prasad R, Qin Y, Johnson M, Wang Q, Vanderveer-Harris N, Pham A, Alvarado AG, Condro M, Gao F, Gau R, Castro MG, Lowenstein PR, Deb A, Hinman JD, Pajonk F, Burns T, Goldman S, Geschwind DH, Kornblum HI. P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells into vascular-like cells. Nature Communications 13(1):6202 (2022).
Ghochani Y*, Muthukrishnan SD*, Sohrabi S, Kawaguchi R, Bastola S, Coppola G, Iruela-Arispe L, Goldman SA, Nakano I, Kornblum HI. A molecular interactome of the glioblastoma perivascular niche reveals Integrin Binding Sialoprotein as a key mediator of tumor cell migration. Cell Reports (2022) *Co-first authors
Alvarado AG, Tessema K, Muthukrishnan SD, Sober M, Kawaguchi R, Laks DR, Bhaduri A, Swarup V, Nathanson DA, Geschwind DH, Goldman SA, Kornblum HI. Pathway based approach reveals differential sensitivity of glioblastoma to E2F1 inhibition. Cancer Research Communications (2022)
Ludwig K, Le Belle JE, Muthukrishnan SD, Sperry J, Condro M, Vlashi E, Pajonk F, Kornblum HI. NAPDH oxidase promotes glioblastoma radiation resistance in a PTEN-dependent manner. Antioxidants and Redox Signaling (2023)
Complete List of Published Work in My Bibliography
https://www.ncbi.nlm.nih.gov/myncbi/sreedeepthi.muthukrishnan.1/bibliography/public/