https://medicine.ouhsc.edu/Academic-Departments Parent Page: Academic Departments id: 23109 Active Page: Our Teamid:23118

Faculty

Peter Vitiello, PhD
Pediatrics

Peter Vitiello, PhD

Associate Professor
Director of Laboratory Research


800 Research Parkway, Suite 462
Oklahoma City, OK 73104

405-271-5215

Peter-Vitiello@ouhsc.edu


Dr. Vitiello is Director of the Laboratory Research for Neonatal-Perinatal Medicine. His research uses molecular and cellular approaches to determine the molecular influence of environmental toxins, oxidative stress, and antioxidant enzymes on tissue development, homeostasis, and disease pathogenesis. He uses experimental models of oxidative diseases including bronchopulmonary dysplasia (BPD) and Friedreich’s Ataxia to discover redox-dependent signaling mechanisms underlying pathogenesis.


MyNCBI Publications

Fun Fact: "I was on the New York City Championship Math Team in middle school."


Academic Section(s):

Neonatal-Perinatal Medicine


Education:

PhD - University of Rochester School of Medicine & Dentistry, Rochester NY
Postdoctoral Fellowship - University of Rochester School of Medicine & Dentistry, Rochester NY


Clinical/Research Interests:

The Vitiello laboratory works to identify and define the molecular interface between environmental toxins and biological systems. Research is targeted at understanding redox-dependent regulation of molecular networks regulating cellular programming during tissue development and injury/repair processes. Dr. Vitiello is specifically researching if thioredoxin antioxidants serve as molecular sensors of altered atmospheric oxygen tension in lung epithelial cells during development and bronchopulmonary dysplasia (BPD), a form of chronic lung disease in the preterm lung. He is also testing how mitochondrial antioxidants regulate redox signaling and mitochondrial function during pathogenesis of Friedreich’s Ataxia, a degenerative neuromuscular disease primarily diagnosed in adolescence. Using a variety of genetic, molecular, proteomic, and cellular approaches, the laboratory hopes to develop new diagnostic and therapeutic strategies to predict, ameliorate, and prevent the life-long burden of oxidative diseases.


Select Honors & Accomplishments:

2020 - Outstanding Reviewer Award, Experimental Biology and Medicine

2019 - Distinguished Researcher Award, USD SSOM Department of Pediatrics

2013-2014 - T. Denny Sanford Pediatric Collaborative Research Award, Sanford Health

2009 - Best Poster Presentation, European Respiratory Society Meeting

2008-2010 - Pediatric Research Loan Repayment Program, NIH

2008 - Harold Hodge Award, University of Rochester School of Medicine & Dentistry

2006 - Bristol-Myers Squibb Travel Award, University of Rochester School of Medicine

2006 - William F. Neuman Award, University of Rochester School of Medicine

2006 - Gilbert B. Forbes Prize in Pediatrics, University of Rochester School of Medicine 


Select Publications:

  • Booze ML, Hansen J, and Vitiello PF. A novel mouse model for the identification of thioredoxin-1 protein interactions. Free Rad Biol Med v99:533-43, 2016. PMID 27639450. PMC5107173.
  • ​Baack ML, Forred BJ, Jensen DN, Khan M, Larsen T, Wachal AL, and Vitiello PF. Consequences of a maternal high fat diet and late gestation diabetes on the developing rat lung. PLOS One v11:e0160818, 2016. PMID 27518105. PMC4982689.
  • ​Forred BJ, Daugaard DR, Titus BK, Wood RR, Floen MJ, Booze ML, and Vitiello PF. Detoxification of mitochondrial oxidants and apoptotic signaling are facilitated by thioredoxin-2 and peroxiredoxin-3 during hyperoxic injury. PLOS One v12:e0168777, 2017. PMID 28045936. PMC5207683.