Academic Section(s):
Neonatal-Perinatal
Education:
Medical School: NRS Medical College & Hospital, Kolkata, West Bengal, India
Residency: Jackson Memorial Hospital - University of Miami, Flordia
Fellowship: Rainbow Babies & Children's Hospital - Case Western Reserve University, Cleveland, Ohio
Board Certification(s):
Board-certified for General Pediatrics, American Board of Pediatrics
Board-certified for Neonatal-Perinatal Medicine
Clinical/Research Interests:
As a neonatologist and physician-scientist, Dr. Ganguly’s clinical and research interests center on bronchopulmonary dysplasia (BPD), a chronic lung disease affecting premature infants, and the long-term respiratory problems experienced by survivors of extreme prematurity. Survivors of extreme prematurity frequently develop recurrent respiratory infections, wheezing and asthma-like symptoms, and are at increased risk for chronic obstructive pulmonary disease (COPD) early in adulthood.
Dr. Ganguly's research asks a fundamental question: Why do the developing airways of premature infants become injured and remodel abnormally, and can this process be prevented? His laboratory investigates how oxidative stress - including exposure to the supplemental oxygen therapy - alters mitochondrial function and other pathways that regulate airway development, differentiation, and repair. A central feature of his translational research program is the use of patient-derived airway epithelial cells isolated from tracheal aspirates of premature infants and grown as three-dimensional organotypic models, complemented by experimental animal models of neonatal lung injury. By integrating these models with mitochondrial, transcriptomic and proteomic approaches, his laboratory seeks to understand why some premature infants develop severe BPD and airway disease while others demonstrate greater resilience. The long-term goal of his research is to develop therapeutic strategies to prevent lifelong respiratory disease in infants born prematurely.
Dr. Ganguly's research is supported by grant funding from the National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI), as well as foundation and institutional sources.
Select Honors & Accomplishments:
2026: Reviewer, NHLBI Pulmonary Injury Remodeling and Repair (PIRR) Study Section
2024 – 2025: American Physiological Society/Society for Pediatric Research (APS/SPR) Research Journey Award
2021: Travel award for Perinatal Research Society (PRS) – Grant Writing Workshop, Tampa, FL, USA
2019: Travel award for Pediatric Academic Society 2019, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, OH, USA
2018 – 2019: William Randolph Hearst research fellow in Neonatology, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, OH, USA
2018: Program representative for the NICHD Clinician Scientist Investigators Meeting, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Potomac, MD, USA
2018: Young Investigator Award, 5th Annual Neonatal Cardiopulmonary Biology: Young investigator Forum, Chicago, IL, USA
2007: Scholastic Award, West Bengal University of Health Sciences, Kolkata, India
Select Publications:
- Ganguly A*, Carter CM, Rivera Negron A, Zhong H, Moreira A, Walters MS, Rogers LK, Prakash YS, Tipple TE, Richardson A. Quantitative proteomics links mitochondrial dysfunction to metabolic changes and epithelial differentiation defects in hyperoxia-exposed neonatal airway cells. Am J Physiol Lung Cell Mol Physiol. 2026 Jan 1;330(1):L87-L103. doi: 10.1152/ajplung.00205.2025. Epub 2025 Dec 5. PMID: 41348646; PMCID: PMC12928458.
- Ganguly A*, Carter CM, Rivera Negron A, Pierce PT, Rogers LK, Walters MS, Prakash YS, Tipple TE, Richardson A. 3-Mercaptopyruvate sulfurtransferase regulates mitochondrial metabolism and epithelial differentiation in neonatal patient-derived airway cells. Am J Physiol Lung Cell Mol Physiol. 2026 May 1;330(5):L557-L566. doi: 10.1152/ajplung.00418.2025. Epub 2026 Mar 28. PMID: 41902666.
- Carter CM, Mathias MM, Bailey-Downs L, Tipple TE, Vitiello PF, Walters MS, Ganguly A*. Translational 3D-Cell Culture Model to Assess Hyperoxia Effects on Human Neonatal Airway Epithelial Cells. J Vis Exp. 2024 Jul 12;(209). doi: 10.3791/65913. PMID: 39072632.
- Mayer CA, Ganguly A, Mayer A, Pabelick CM, Prakash YS, Hascall VC, Midura RJ, Cali V, Flask CA, Erokwu BO, Martin RJ. CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3. Pediatric Research. 2021 Nov 8:1-9. PMID: 34750521
*Corresponding author
MyNCBI Publications Link