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Faculty

Stacy Hussong, PhD
Biochemistry and Physiology

Stacy Hussong, PhD

Assistant Professor of Research, Department of Biochemistry & Physiology

940 Stanton L. Young Blvd., BMSB 823
Oklahoma City, OK 73104

(405) 271-2227 ext. 61205

stacy-hussong@ouhsc.edu

Education:

Ph.D. University of Minnesota, PhD, Graduate program in Biochemistry, Molecular Biology and Biophysics (BMBB), Minor: Gerontology, 2010
B.S. University of South Dakota: Bachelor of Science, Department of Chemistry and Department of Biology, 2005

Select Publications:

  1. Ethen, C.M., Hussong, S.A., Reilly, C., Feng, X., Olsen, T.W., Ferrington, D.A. 2007. Transformation of the proteasome with age-related macular degeneration. FEBS Letters 581: 885-890. PMCID: PMC1850528
  2. Ferrington, D.A., Hussong, S.A., Roehrich, H., Kapphahn, R.J., Kavanaugh, S., Heuss, N. and Gregerson, D.S. 2008. Immunoproteasome responds to injury in the retina and brain. J Neurochem. 106: 158-169. PMCID: PMC4401486
  3. Hussong, S.A., Kapphahn, R.J., Phillips, S.L., Maldonado, M., and Ferrington, D.A. 2010. Immunoproteasome deficiency alters retinal proteasome’s response to stress. J Neurochem. 113: 1481-1490. PMCID: PMC2909641
  4. Hussong, S.A., Roehrich, H., Kapphahn, R.J., Maldonado, M., Pardue, M.T., and Ferrington, D.A. 2011. A novel role for immunoproteasome in retinal function. Invest Ophthalmol Vis Sci., 52: 714-723. PMCID: PMC3053103
  5. Halloran, J.*, Hussong, S.A.* (*authors contributed equally), Burbank, R.R., Podlutskaya, N., Fischer, K., Sloane, L., Austad, S., Strong, J.R., Richardson, A., Hart, M., Galvan, V. 2012. Chronic inhibition of mTOR by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice. Neuroscience 223C:102-113. PMCID: PMC3454865
    Recommended by Faculty of 1000
  6. Pierce,A.,Podlutskaya,N.,Hussong,S.A.,Halloran,J.J.,Burbank,R.R.,Strong,J.R.,Richardson,A., Hart M.J., Galvan, V. 2012. Upregulation of heat shock proteins by chronic rapamycin treatment lowers Aβ and prevents cognitive impairment in mice modeling Alzheimer’s disease. J Neurochem. 124: 880- 893.
  7. Lin,A.-L.,Zheng,W.,Halloran,J.J.,Burbank,R.R.,Hussong,S.A.,Hart,M.J.,Javors,M.,Shih,Y.-Y., Muir, E., Solano Fonseca, R., Strong, R., Richardson, A.G., Lechleiter, J.D., Fox, P.T., and Galvan, V. 2013. Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer’s disease. J Cereb Blood Flow Metab. 33: 1412-1421. PMCID: PMC3764385
  8. Lin,A.-L.,Pulliam,D.,Sathyaeelan,D.,Halloran,J.,Hussong,S.A.,Burbank,R.,Bresnen,A.,Liu,Y., Podlutskaya, N., Soundararajan, A., Muir, E.; Duong, T., Bokov, A., Viscomi, C., Zeviani, M., Richardson, A., Van Remmen, H., Fox, P., Galvan, V. 2013. Decreased mitochondrial function with Surf1-deficiency enhances brain metabolism, blood flow and memory in mice. J Cereb Blood Flow Metab. 33: 1605-1611. PMCID: PMC3790931 Recommended by Faculty of 1000
  9. Heuss, N.D., Pierson, M.J., Montaniel, K.R., McPherson, S.W., Lehmann, U., Hussong, S.A., Ferrington, D.A., Low, W.C., Gregerson, D.S. 2014. Retinal dendritic cell recruitment, but not function, was inhibited in MyD88 and TRIF deficient mice. J Neuroinflammation. 11:143. PMCID: PMC4149240
  10. Bai, X., Hussong, S.A. 2014. A new mouse model to study compensatory mechanisms that support normal motor function in Parkinson’s disease. J. Biochem. Pharmacol. Res. 2(2): 54-56. PMCID: PMC4578241 (Literature Review)
  11. Schuld, N.J.*, Hussong, S.A.* (*authors contributed equally), Kapphahn, R.J., Lehmann, U., Roehrich, H., Rageh, A., Heuss, N., Gregerson, D.S., Ferrington, D.A. 2015. Immunoproteasome deficiency protects the retina after optic nerve crush. PloS One 10(5):e0126768. PMCID: PMC4433222
  12. Jahrling, J.B., Lin, A, DeRosa, N., Hussong S.A., Van Skike, C.E., Girotti, M., Javors, M., Zhao, Q., Maslin, L.A., Asmis, R.,Galvan, V. 2018. mTOR Drives Cerebral Blood Flow and Memory Deficits in LDLR- /- Mice Modeling Atherosclerosis and Vascular Cognitive Impairment. Journal of Cerebral Blood Flow and Metabolism. 38(1): 58-74. PMCID: PMC5757441
  13. Van Skike, C.E., Jahrling, J.B., Olson, A.B., Sayre, N.L., Hussong, S.A., Ungvari, Z., Lechleiter, J.D., Galvan, V. 2018. Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer’s disease and vascular cognitive impairment. Am J Physiol Heart Circ Physiol. 314(4): H693-H703. PMCID: PMC5966773
  14. Zhang, S.Y., Clark, N.E., Freije, C.A., Pauwels, E., Taggart, A., Okada, S., Mandel, H., Garcia, P., Ciancanelli, M.J., Biran, A., Lafaille, F.G., Tsumura, M., Cobat,A., Luo, J., Volpi, S., Zimmer, B., Sakata, S., Dinis, A., Ohara, O., Garcia-Reino, E.J., Dobbs, K., Hasek, M., Holloway, S.P., McCammon, K., Hussong, S.A., DeRosa, N., Lorenzo, L., Hyodo, Van Skike, C.E., Katolik, A., Faria, E., Halwani, R., Fukuhara, R., Galvan, V., Damha, M.J., Al-Muhsen,S., Itan, Y., Boeke, J.D., Notarangelo, L.D., Studer, L., Kobayashi, M., Diogo, L., Fairbrother, W., Abel, L., Rosenberg, B., Hart, J., Etzioni, A., Casanova, J.L. 2018. Inborn errors of lariat metabolism in humans with viral infections of the brainstem. Cell. 172(5): 952-965. PMCID: PMC5886375
  15. Van Skike, C.E., Lin, A-L., Burbank Roberts, R.R., Halloran, J.J., Hernandez, S.F., Cuvillier, J., Soto, V., Hussong, S.A., Jahrling, J., Javors, M., Hart, M.J., Fischer, K., Austad, S.A., and Galvan, V. 2020. mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging. Aging Cell. 19(1): e13057. PMCID: PMC6974719.
  16. Dorigatti, A.O.*, Hussong, S.A.* (*authors contributed equally), Hernandez, S.F., Sills, A.M., Salmon, A.B., Galvan, V. 2020. Primary neuron and astrocyte cultures from postnatal Callithrix jacchus: a non- human primate in vitro model for research in neuroscience, nervous system aging, and neurological diseases of aging. GeroScience. 43(1): 115-124. PMCID: PMC8050148.
  17. Van Skike, C.E., Hussong, S.A., Hernandez, S.F., Banh, A.Q., DeRosa, N., Galvan, V. 2021. mTOR attenuation with rapamycin reverses neurovascular uncoupling and memory deficits in mice modeling Alzheimer's disease J. Neuroscience. 41(19): 4305-4320. PMCID: PMC8143195.
  18. Hussong, S.A.*, Banh, A.Q.*, (*authors contributed equally), Van Skike, C.E., Olson, A.B., Hernandez, S.F., Hart, M.J., Gazynska, M., Osmulski, P.A., McAllen, S.A., Dineley, K.T., Ungvari, Z., Pérez, V.I., Kayed, R., and Galvan, V. Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in tauopathy. In revision for Nature Communications.
  19. Hussong, S.A.*, Van Skike, C*.E., (*authors contributed equally), DeRosa, Nicholas, and Galvan, Veronica. 2022. Rapamycin restores peripheral blood flow in aged mice and in mouse models of atherosclerosis and Alzheimer’s disease. In revision for GeroScience.
  20. Hussong S.A., Burbank RR, Halloran JJ, DeRosa, N.D., Lin AL, Van Skike, C., Walsh, M.E., Bokov, A., Romero, P., Soto, V.Y., Liu, Y., Maslin, K., Van Remmen H, Austad, S.A., Fox, P.T., and Galvan V. Cell-autonomous and non-cell-autonomous regulation of brain and peripheral metabolism by neuronal mTORC1 signaling. **In preparation, to be submitted to Cell Metabolism.
  21. Hussong, S.A., Galvan, V. mTORC1 regulates AMPK-dependent eNOS activation in brain vascular endothelial cells. In preparation, to be submitted to Journal of Cerebral Blood Flow and Metabolism.