CURRENT RESEARCH SUPPORT
Principal Investigator
1. R01CA221819 (PI: Businelle) 02/01/2019-01/31/2024
NIH/NCI (Clinical Trials#: NCT03740490)
Smartphone Based Smoking Cessation Intervention for Socioeconomically Disadvantaged Adults
This
study (N=450) will compare the longer-term effects of the Smart-T
smoking cessation app with the free and publically available NCI
QuitGuide smoking cessation app (Aim 1). The second aim will determine
if Smart-T messages that are tailored to address key smoking lapse risk
variables in real-time (i.e., urge, stress, cigarette availability,
cessation motivation) reduce participant ratings of these lapse risk
variables compared with similar situations that do not receive this
tailored content (QuitGuide group).
Direct & Indirect: $2,695,044 (Direct: $1,858,651)
Effort: 23.3%
2. R01MD010733 (PIs: Businelle & Reingle) 09/26/2017-05/31/2022
NIH/NIMHD (Clinical Trials#: NCT03399500)
mHealth to Increase Service Utilization in Recently Incarcerated Homeless Adults
This
3-armed randomized clinical trial will use an innovative smartphone
application to identify and address barriers that prevent recently
incarcerated homeless adults from obtaining available case management,
crisis management, substance abuse, and mental health services.
Direct & Indirect: $3,326,084 (Direct: $2,627,219)
Effort: 25%
3. R34AA024584 (PIs: Businelle & Walters) 06/01/2018–05/31/2020
NIH/NIAAA (Clinical Trials#: NCT03746808)
Development and Testing of a Just-in-Time Adaptive Smart Phone Intervention to Reduce Drinking
among Homeless Adults
The
aims of this study are to identify predictors of heavy drinking and
develop and test a just-in-time adaptive intervention to prevent heavy
drinking days in a sample of homeless adults with Alcohol Use Disorder.
Direct & Indirect: $665,384 (Direct: $515,108)
Effort: 15%
4. TSET 092-016-0002 (PIs: Businelle & Kendzor) 07/01/2019–06/01/2020
Oklahoma Tobacco Research Center
Direct & Indirect: $3,800,000 (Direct: $3,454,545)
Effort: 5%
5. OUHSC Pilot Funds (PI: Businelle; NCT03405129) 06/01/2018–05/31/2020
Project Phoenix: Pilot Intervention for Smokers Who Are Not Ready to Quit Smoking
The
primary long-term objective of this research is to increase smoking
cessation attempts and reduce smoking relapse through the use of
automated phase based mobile smoking cessation interventions. The
primary short-term objective of this pilot study is to determine the
initial utility of the novel Phoenix smartphone based smoking cessation
app.
Direct & Indirect: OUHSC funds
6. OUHSC Pilot Funds (PI: Businelle & Funk-Lawler)
Project Persist: mHealth for Cancer Survivorship
This
pilot randomized controlled trial (RCT) will assess the initial
feasibility of a phone-delivered intervention for anxiety and depressive
symptoms among cancer patients that are receiving active radiation
treatments. A total of 60 participants will be randomized to in-person
and smartphone-based assessment only (n=30) or assessment plus
smartphone-based intervention (n=30).
Co-Investigator
7. R01CA231952 (PIs: D. Vidrine & J. Vidrine) 04/01/2019–03/31/2024
NIH/NCI
Partnering with a State Food Bank to Provide Tobacco Treatment to Underserved Smokers
The
overall goal of this project is to collaborate with a large food bank
to evaluate the efficacy and economic impact of a theoretically-based,
fully automated, interactive smartphone-based smoking cessation
intervention.
Effort: 4%
8. P30 CA225520 (PI: Mannel; Businelle: Director mHeath Shared Resource) 05/01/2018–04/30/2023
NIH/NCI
Stephenson Cancer Center – Cancer Center Support Grant
Dr.
Businelle is the Scientific Director of the NCI designated Stephenson
Cancer Center mHealth Shared Resource. The shared resource enables
researchers to rapidly create mobile applications that identify
environmental, cognitive, affective, physiological and behavioral
antecedents of cancer risk behaviors (e.g., smoking, heavy alcohol use,
poor diet, inactivity, obesity, etc.) and deliver context-specific
adaptive interventions in real time.
Total Direct: $7,000,000
Effort: 10%
9. U01 DA045537 (PI: Wagener) 8/01/2018–07/31/2020
NIH/NIDA
Switching to the SREC: Evaluating Risk Reduction among Quitline Treatment Failures
The
specific aims of this project are: 1) to assess nicotine SREC vs.
placebo SREC on product switching/substitution, craving/withdrawal,
abuse liability, number of cigarettes smoked, and perceived nicotine
dependence, 2) to evaluate changes in biomarkers of tobacco constituent
exposure and physiological effects, and 3) to evaluate which e-cigarette
device characteristics and perceived effects influence complete (vs.
partial or no substitution).
Total Direct ($998,213) and Total Costs ($1,489,354)
Effort: 7.5%
10. R01CA197314 (PI: Kendzor) 07/08/2015–06/30/2020
NIH/NCI
Small Financial Incentives to Promote Smoking Cessation in Safety Net Hospital Patients
This
randomized clinical trial will examine the longer-term effects of
offering small financial incentives for confirmed smoking abstinence in
safety-net hospital patients who are seeking smoking cessation
treatment. In addition, traditional and ecological momentary assessments
will be used to identify antecedents of smoking lapse.
Total Direct ($1,127,995) and Total Costs ($1,619,450)
Effort: 5%
11. R21DA046333 (PIs: Wagener & Villanti) 09/15/2018–08/31/2020
NIH/NIDA
Addiction and Behavior Related to Menthol Cigarette Substitutes
This
study will address an important gap in the menthol cigarette literature
as to how alternative menthol tobacco products may serve as substitutes
for menthol cigarettes in the context of a menthol ban in cigarettes
and potentially undermine public health.
Total Direct Costs: $427,742
Effort: 4%
12. Project SmartPath (PI: Kendzor) 09/01/2016–08/31/2019
OUHSC Pilot Funds
Evaluation of a Smartphone Intervention to Reduce Sedentary Behavior
The
aims of the study are to 1) evaluate the efficacy of a “real-time”
smartphone intervention that works in conjunction with a wearable
activity monitoring device to reduce sedentary time via smartphone
prompts during prolonged sedentary bouts (relative to 2 comparison
groups [AO and EQ]) and 2) to identify treatment mechanisms and
contextual factors associated with sedentary behavior using traditional
and ecological momentary assessment approaches.
Direct & Indirect: OUHSC funds
13. Grant/Contract Number: WI246498 (MPIs: Kendzor & Hébert) 12/15/2018–12/14/2020
OUHSC Pilot Funds and Pfizer (medication)
A comparison of the effectiveness of combination varenicline and oral nicotine
replacement therapy versus varenicline alone for smoking cessation: A pilot study
This
pilot study will provide information regarding the feasibility,
acceptability, and preliminary efficacy of combination varenicline and
oral NRT for smoking cessation, which will support an NIH funding
application for a larger, adequately powered study.
Total Costs ($150,000)
Effort: in kind
Consultant
14. R01NR017837 (PI: Santa Maria) 01/01/2019–05/31/2023
NIH/NINR
Come
As You Are - Assessing the Efficacy of a Nurse Case Management HIV
Prevention and Care Intervention among Homelessness Youth
This
study is a randomized controlled trial of an enhanced Nurse Case
Management intervention that will be delivered over 3 months to assess
its impact on HIV risk behaviors.
Total Costs: $3,085,854
Mentor
15. R01CA221819-01A1S1 (PI: Businelle) 09/01/2019-01/31/2021
The Application of a Smartphone-Based Smoking Cessation Tool with American Indian Adults
This
NCI Diversity Supplement will support Dr. Ashley Cole’s development
into an independent researcher. This study involves qualatative
examination of ways the Smart-T3 app can be culturally tailored for
American Indian smokers seeking smoking cessation treatment.
Total costs: $327,562
Role: Mentor
16. K01HL148907 (PI: Alayna P. Tackett) 08/21/2019-07/31/2024
NIH/NHLBI
Respiratory effects of E-Cigarette use among Youth: A prospective, longitudinal investigation
This
Tobacco Regulatory K01 will provide much needed evidence regarding the
immediate and longitudinal respiratory/pulmonary effects of youth
electronic cigarette use.
Total costs: $963,190
Role: Mentor
17. K99DA046564 (PI: Emily Hébert) 03/01/2019–02/28/2021
NIH/NIDA
Using Machine Learning to Develop Just-in-Time Adaptive Interventions for Smoking Cessation
Direct & Indirect: $179,883
Role: Primary mentor
18. F31DA047015 (PI: Samantha Schiavon) 07/01/2018-05/31/2021
NIH/NIDA
Balanced Placebo Design with Varenicline: Pharmacological and Expectancy Effects on Medication Adherence
This double-blind placebo controlled trial is designed to differentiate expectancies
versus pharmacologic mechanisms of varenicline administered to treatment-seeking smokers.
Direct Costs: $102,223
Role: Mentor
COMPLETED RESEARCH SUPPORT
Principal Investigator
1. OUHSC Pilot Funds (PI: Businelle; NCT02930200) 09/01/2016–08/31/2018
Pilot Randomized Clinical Trial of an Automated Smartphone based Smoking Cessation Treatment
This
pilot study is a 3 armed randomized clinical trial that aims to
determine the initial utility of a novel smartphone based smoking
cessation intervention (i.e., Smart-T) compared with standard in-person
smoking cessation clinic care and the free NCI QuitGuide smoking
cessation application. Results of this study will be used to support the
development of a fully powered NCI R01 application.
Direct & Indirect: OUHSC funds
2. MRSG-12-114-01-CPPB (PI: Businelle) 07/01/2012–07/10/2017
American Cancer Society (Mentored Research Scholar Grant)
Socioeconomic Disparities in Smoking Cessation: Identifying the Mechanisms
This
study will determine if low SES increases the odds of relapse through a
number of hypothesized mechanisms. This work is innovative because it
will explore mediational pathways between SES and smoking cessation
among individuals of varying racial/ethnic backgrounds from two distinct
samples, using both traditional (questionnaire) and
state-of-the-science real-time assessment methodology. This information
was used to develop a new smart phone–based smoking cessation treatment
that assesses relapse risk in real time and automatically intervenes to
reduce risk (Project Smart-T).
Direct & Indirect Costs: $717,000
3. Project Advance II (PI: Businelle) 06/29/2016–06/1/2018
Advance Understanding of Health in Homeless Shelter Patrons
The
primary objective of this anonymous cross-sectional questionnaire study
is to gain a better understanding of the prevalence of physical and
mental health problems among homeless adults in Oklahoma City. The
secondary objective is to identify risk (e.g., stress, pain) and
protective (e.g., levels of social support) factors that have an impact
on health behavior and health behavior change in this understudied and
underserved population.
Direct & Indirect: OUHSC funds
4. Project Advance (PI: Businelle) 05/01/2013–08/31/2014
University
of Texas School of Public Health (GRA support) & The University of
Texas MD Anderson Cancer Center (funded subject payments)
The Effects of a Smoking Policy Change at a Homeless Shelter
The
primary objective of this project was to examine homeless individuals’
attitudes and beliefs about partial and full smoking bans at a local
shelter before and after a partial smoking ban is implemented and to
examine the short-term consequences of this ban. The secondary objective
of this study was to determine the prevalence of modifiable cancer risk
factors among a sample of homeless individuals.
Direct Costs (No Indirect Costs): $15,000
5. Start Up Project (Project Prevail; Co-PIs: Businelle & Kendzor) 08/23/2011–07/31/2013
University of Texas School of Public Health
Adjunctive Contingency Management to Promote Smoking Abstinence
The
primary objectives of this study were: 1) to evaluate the efficacy of
an adjunctive contingency management intervention for smokers of low
socioeconomic status participating in a smoking cessation program at an
urban safety net clinic (Parkland Tobacco Cessation Clinic), and 2) to
identify barriers to smoking cessation and predictors of relapse in this
population.
Direct Costs (No Indirect Costs): $85,000
6. PILOT Grant (Project Aspire; PI: Businelle) 11/15/2011–02/15/2013
University of Texas School of Public Health
Reducing Tobacco Related Disparities among the Homeless
The
primary objectives of this pilot project were to: 1) determine if
ecological momentary assessment (EMA) methodology could be used to
identify predictors of and barriers to successful smoking cessation in
treatment seeking homeless smokers, and 2) determine if an adjunctive
contingency management treatment component (i.e., small financial
incentives for biologically confirmed abstinence) would increase
abstinence relative to usual care in this population.
Direct Costs (No Indirect Costs): $25,000
7. Contract (PI for career development funds: Businelle; Effort: 50%) 09/01/2010–06/30/2012
UT Southwestern Medical Center/Harold C. Simmons Comprehensive Cancer Center
Population Level Research on Cancer Prevention
These
funds were awarded to Dr. Businelle to support the development of his
cancer prevention research laboratory in Dallas and to expedite research
methods and data analysis for the Harold C. Simmons Comprehensive
Cancer Center.
Direct Costs (No Indirect Costs): $90,654
8. R25-T CA57730 (PI: Chamberlain; PI for postdoctoral fellowship project: Businelle; Effort: 100%)
01/01/2008–12/31/2009
NIH/NCI
Pathways Linking Socioeconomic Status and Smoking Cessation
The
major goal of this project was to examine pathways linking
socioeconomic status to smoking cessation using a structural equation
modeling approach.
Direct Costs (No Indirect Costs): $120,000
Co-Investigator
9. R01CA197314 Supplement (PI: Kendzor) 07/01/2016–06/30/2019
NIH/NCI Supplement
Mobile Contingency Management for Smoking Cessation Among Socioeconomically Disadvantaged Adults
The
purpose of the supplement is to 1) develop a fully automated, mobile
phone-based CM approach that can remotely verify smoking abstinence,
confirm participant identity, and deliver financial incentives for
smoking cessation, and 2) evaluate the feasibility and preliminary
effectiveness of using a fully automated mobile CM approach as an
adjunct to telephone counseling and nicotine replacement therapy among
socioeconomically disadvantaged adults.
Total Direct ($80,550)
Effort: 10% year 1; in kind years 2-3
8. Houston Endowment Inc. (PI: Tortolero) 01/01/2015–11/30/2016
A Comprehensive Community-wide Approach to Adolescent Sexual Health
This
study will use smart phone technology to assess health behaviors
including sexual behavior, safe sex practices, and alcohol/drug use
among a sample of at-risk adolescents and homeless youths. My role on
this project is to guide the design of the smart phone–based data
collection program and to assist with analyses of EMA data.
Total Direct Costs: $6,000,000; Current Year Direct Costs: $2,000,000
Effort: 10% in 2015; in kind 2016
9. U01AA016668 (PI: Adinoff) 02/01/2011–01/31/2013
NIH/NIAAA
Stress, HPA Axis Dysfunction, and Relapse in Alcoholism
The
primary goal of this project was to examine the interaction between
stress and HPA axis dysfunction and its impact on relapse in a sample of
alcohol dependent men.
Subcontract Direct Costs (No Indirect Costs): $24,954
Effort: 10%
10. IRG-02-196-07 (PI: Kendzor) 01/06/2014–10/01/2015
American Cancer Society (Institutional Research Grant)
Evaluation of a Shelter-Based Diet and Physical Activity Intervention for Homeless Adults: A Pilot Study
This
pilot randomized clinical trial will evaluate the feasibility and
effectiveness (relative to an assessment-only control group) of a
shelter-based intervention designed to improve dietary intake and
increase physical activity among homeless individuals.
Direct Costs (No Indirect Costs): $30,000
Mentor
11. R25/CA57712 (PI: Mullen) 09/01/2013–10/1/2015
NCI/NIH
Behavioral Science Education-Cancer Prevention and Control
Direct and Indirect Costs: $2,499,817
12. CPRIT (PIs: Ness & Mullen) 2014-2015
Collaborative Training of a New Cadre of Innovative Cancer Prevention Researchers
Direct and Indirect Costs: $1,700,000
Role: Mentor (in Kind)
13. P50 CA180906 (PI: Cooper) 09/01/2015–10/31/2015
NIH/NCI TCORS Pilot Grant
Assessing Young Adult E-cigarette Use with Ecological Momentary Assessment
The purpose of thise study is to investigate e-cigarette use behaviors and antecedents associated with use among young adults.
Direct costs: $19,235 (no indirect costs)
Role: Mentor (in Kind)
Consultant14. R25 HD045810 to University of California, San Francisco 09/1/2016–8/31/2017
NIH, NICHD - Center for AIDS Prevention Studies (PI: Santa Maria)
Development of a HIV Risk Estimator to Predict Imminent HIV Risk Behaviors in Homeless YouthThe
goal of this project is to identify antecedents to HIV risk behaviors
and combine this information to develop a real-time HIV risk estimator
using existing EMA data from 71 homeless 18-24 year olds recruited from a
local drop-in center in Houston, TX.
Direct and Indirect Costs: $20,000
15. PARTNERS Foundation (PI: Santa Maria) 08/01/2018–07/31/2019
MY-RID: Motivating Youth to Reduce Infections and DisconnectionsUsing
a participatory research model, a personalized nurse-led, mobile
enhanced, HIV prevention intervention for youth experiencing
homelessness and unstably housing will be developed. Once developed and
beta tested, we will conduct a small randomized attention control trial
to assess the feasibility, acceptability, and preliminary efficacy of
the intervention.
Direct & Indirect: $100,000
Role: Consultant
16. DSRIP (1115) (PI: Walters) 01/26/2014–12/31/2016
Centers for Medicare & Medicaid Services, Delivery System Reform Incentive Payment Program
Health Navigation Incentives for Dual Diagnosis PatientsProvide
consultation on the development of an application that uses mobile
technology for real-time assessment and intervention among people
enrolled in Fort Worth permanent supportive housing.
Direct and Indirect Costs: $2,488,150