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Faculty and Staff

Faculty

Jie Wu, PhD
Pathology

Jie Wu, PhD

Professor of Pathology
Peggy and Charles Stephenson Endowed Chair in Cancer Translational Research
Co-leader, Cell Signaling and Oncogenes Team, Stephenson Cancer Center
Oklahoma TSET Research Scholar


The University of Oklahoma Health Sciences Center
Stanton L. Young Biomedical Research Center
975 NE 10th St, Rm BRC 411B
Oklahoma City, OK 73104

405-271-8001, x 31092

jie-wu@ouhsc.edu


Education:

  • Xiamen University
    Xiamen, China
    B.S., 1982
  • Shanghai Institute of Cell Biology
    Chinese Academy of Sciences
    Shanghai, China
    Graduate Student, 1983
  • University of Kansas Medical Center
    Kansas City, KS
    Ph.D., 1988
  • Memorial Sloan-Kettering Cancer Center
    New York, NY
    Postdoc, 1990
  • University of Virginia
    Charlottesville, VA
    Postdoc, 1994


Clinical/Research Interests:

  • Protein kinases and phosphatases
  • Tumor biology
  • Animal models
  • Cancer genomics
  • Drug discovery and development
  • Sensitivity and resistance to therapy
  • Precision medicine


Select Publications:

  1. Dorsey JF, Cunnick JM, Mane SM, and Wu J. Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of the Bcr-Abl+ K562 cells by Gab2. Blood. 2002 Feb; 99(4): 1388-1397.
  2. Ren Y, Chen Z, Chen L, Woods NT, Reuther GW, Cheng JQ, Wang HG, and Wu J. Shp2E76K mutant confers cytokine-independent survival of TF-1 myeloid cells by up-regulating Bcl-XL. J Biol Chem. 2007 Dec; 282(50): 36463-36473.
  3. Ren Y, Zhang Y, Liu RZ, Fenstermacher DA, Wright KL, Teer JK, and Wu J. JAK1 truncating mutations in gynecologic cancer define new role of cancer-associated protein tyrosine kinase aberrations. Sci Rep. 2013 Oct; 3, 3042; doi:10.1038/srep03042.
  4. Schneeberger V, Luetteke N, Ren Y, Berns H, Chen L, Foroutan P, Martinez GV, Haura EB, Chen J, Coppola D, and Wu J. (2014) SHP2E76K mutant promotes lung tumorigenesis in transgenic mice. Carcinogenesis. 2014 Aug; 35(8):1717-25. doi: 10.1093/carcin/bgu025. Epub 2014 Jan 30.
  5. Schneeberger VE, Ren Y, Luetteke N, Huang Q, Chen L, Lawrence HR, Lawrence NJ, Haura EB, Koomen JM, Coppola D, and Wu J. Inhibition of Shp2 suppresses mutant EGFR-induced lung tumors in transgenic mouse model of lung adenocarcinoma. Oncotarget. 2015 Mar; 6(8): 6191-6202.
  6. Fan C, Chen L, Huang Q, Tao S, Welsh EA, Teer JK, Cai J, Cress WD, and Wu J. Overexpression of major CDKN3 transcripts is associated with poor survival in lung adenocarcinoma. Br J Cancer. 2015 Dec; 113(12): 1735-1743.
  7. Huang Q, Schneeberger VE, Luetteke N, Jin C, Afzal R, Budzevich MM, Makanji RJ, Martinez GV, Shen T, Zhao L, Fung KM, Haura EB, Coppola D, and Wu J. Preclinical modeling of KIF5B-RET fusion lung cancer. Mol Cancer Ther. 2016 Oct; 15, 2521-2529.
  8. Shen T, Chen Z, Zhao ZJ, and Wu J. Genetic defects of the IRF1-mediated major histocompatibility complex class I antigen presentation pathway occur prevalently in the JAK2 gene in non-small cell lung cancer. Oncotarget 2017 May; 8 (37): 60975-60986.
  9. Sun X, Ren Y, Gunawan S, Teng P, Chen Z, Lawrence HR, Cai J, Lawrence NJ, and Wu J. Selective inhibition of leukemia-associated SHP2E69K mutant by the allosteric SHP2 inhibitor SHP099. Leukemia 2018 May; 32 (5), 1246-1249.
  10. Liu X, Shen T, Mooers BHM, Hilberg F, Wu J. Drug resistance profiles of mutations in the RET kinase domain. British J. Pharmacol. 2018 Sept; 175, 3504-3515.



Adjunct Faculty

Prabir K. Chakraborty, PhD

Prabir K. Chakraborty, PhD

Assistant Professor (Research)

Daniel J. Cowden, MD, FCAP, CPHIMS

Daniel J. Cowden, MD, FCAP, CPHIMS

Clinical Associate Professor

Charles Esmon, PhD

Charles Esmon, PhD

Lloyd Noble Chair, Cardiovascular Research

Member & Head, Cardiovascular Biology Research at OMRF

Adjunct Professor, Pathology

Adjunct Professor, Biochemistry

Investigator at Howard Hughes Medical Institute

David M Lewis, DDS

David M. Lewis, DDS

Associate Professor
Department of Oral and Maxillofacial Pathology

Adjunct Associate Professor
Department of Pathology

Yuechueng Liu, PhD

Yuechueng Liu, PhD

Associate Professor of Pathology

Jeffrey McBride, MD, PhD

Jeffrey McBride, MD, PhD

Assistant Professor

Director of Dermatopathology

Adjunct Faculty - Pathology

Charles A. Montgomery, DVM, DACVP, DACLAM

Charles A. Montgomery, DVM, DACVP, DACLAM

Adjunct Professor
Department of Pathology
Division of Comparative Medicine

Kathy L. Moser, PhD

Kathy L. Moser, PhD

Associate Member, Arthritis & Immunology Program
OMRF

Adjunct Faculty, Pathology

Aravindan Natarajan

Aravindan Natarajan, MS., MPhil., PhD., CCA.

Associate Professor, Department of Radiation Oncology,
Associate Professor (Adjunct), Department of Anesthesiology,
Associate Professor (Adjunct), Department of Pathology
Course Director, Radiation Biology for Radiation Oncology Residents
Graduate Faculty, College of Medicine
Member, Cancer Biology Program

Amr H. Sawalha, MD

Amr H. Sawalha, MD

Assistant Member
Arthritis and Immunology Research Program

Assistant Professor of Medicine 
Department of Medicine

Staff Physician 
Veteran Affairs Medical Center
Oklahoma City

Adjunct Faculty
Department of Pathology