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Prospectus: Effect of GLP-1 Agonist Use on Fertility

Resident: Jacey Harmon, MD

Faculty Advisor: Heather Burks, MD

Contributing Authors: Madeline Hightower, BS; Ishan Bhanot, BA, BS; Summer Anwar, BS

Background

Higher BMI is associated with poorer fertility prognosis, and many studies have shown that obesity is associated with increased time-to-pregnancy. Obesity is frequently associated with metabolic syndrome – a cluster of factors including insulin resistance, glucose intolerance, dyslipidemia, and hypertension. The successful use of GLP-1 agonists for weight loss, HgbA1c reduction, decrease in blood pressure, and improvement in dyslipidemia has been well established. There is an emerging role for the use of GLP-1 agonists to increase fertility rates among reproductive-age women.

Methods

We are performing a systematic review. We created search criteria using key words and phrases that was used to identify studies within MEDLINE, Embase, and Cochrane CENTRAL databases. We initially identified 1,480 studies, removed 639 duplicates, and excluded 833 articles as irrelevant. This resulted in 8 studies that will be included in the data extraction process.

Results / Conclusion

The data collection for this project is still ongoing. The goal is for the data collection to be completed this summer.







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Agenda