The Pediatric Metabolic Research Program is
located in the OU Children's Physicians Building, on the fourth floor.
In addition to the Program, this space houses the Pediatric
Diabetes/Endocrinology clinics and academic offices. Our facilities are
well-suited for a broad range of metabolic research, and we are open
to the use of our facilities for collaborative or independent research.
For more information, please contact
Sharon Silliman. See below for highlights from our facilities.
We are one of the few research
centers that can analyze body composition across the lifespan. This is
accomplished using the air displacement plethysmography (PEA POD, TOD
POD, and BOD POD) or dual energy X-ray absorptiometry (GE Lunar
iDXA). In addition to measuring total body composition, these
devices can assess regional composition and bone mineral status. Mobile
measurements can also be made using the Tanita bioelectrical impedence
A MedGraphics Ultima CardiO2 metabolic cart is available for
performing exercise stress tests and for measuring energy expenditure
during exercise. This system includes an ECG and breath-by-breath gas
exchange for indirect calorimetry measurements. Testing can utilize a
treadmill (Trackmaster 425), an electromagnetically braked bicycle (Lode
Corival), or other modes of physical activity.
A canopy flow system (Parvo Medics) with gas mixing chamber
is available for dedicated resting energy expenditure measurements.
Subjects rest quietly during these measurements.
Free-living energy expenditure measurements will soon be
available using the doubly-labeled water method. A small dose of water
labeled with non-radioactive forms of hydrogen (2H) and oxygen (18O) are
given orally and urine collections are obtained regularly for up to 2
weeks thereafter. The rate at which the labeled hydrogen and oxygen
appear in the urine is used to calculate the total energy expenditure
during the measurement period. The measurements are performed using an
isotope ratio-mass spectrometer (ThermoElectron Delta V).
Physical Activity Monitoring
We currently use the StepWatch (Cyma Corporation) to monitor
physical activity patterns in either the laboratory or free-living
situations. The StepWatch is a small accelerometer worn above the ankle.
It can record step frequency in 3-60 second intervals for several days
at a time.
Peripheral Vascular Integrity
Small and large artery elasticity is determined
non-invasively using pulsewave analysis (HDI analyzer). Vascular
endothelial cell function (post-occlusive dilation) is assessed using
the Endo Pat System.
Exercise Training Facility
Our primary exercise training center is a 750 sq ft. room
that contains 6 Precor treadmills, 2 Lode Corival bikes, a Precor
Multigym for weight training, and dumbbells for free weight training. A
separate 360 sq ft room is available for children's play or group
activities. Locker rooms with shower facilities are located adjacent to
the main exercise room.
Dedicated laboratory space includes facilities for
processing of blood samples, tissue culture, and other laboratory
procedures. A range of services are available, such as measurement of
serum insulin, c-peptide, and glucose concentrations.