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Andrei Belousov
Biochemistry and Physiology

Andrei B. Belousov, PhD

Professor and Vice Chair, Department of Biochemistry & Physiology
405-271-8001, ext. 32064

andrei-belousov@ou.edu

Education:

  • B.S. and M.S. Biology and Physiology (MS Thesis with Honors), Kazan State University, Kazan, Russia
  • Ph.D. Neurophysiology, Moscow State University, Moscow, Russia
  • Postdoctoral Fellow, Anesthesia Research Department, McGill University, Montreal, Canada
  • Postdoctoral Fellow, Department of Biological Sciences, Stanford University, Stanford, CA

Clinical/Research Interests:

Teaching Interests

  • Physiology
  • Neuroscience
  • Neurobiology of Disease

Research Focus

Patch-clamp electrophysiology, calcium digital imaging, immunocytochemistry, multiple molecular biology techniques, confocal microscopy, primary cell cultures, acute brain slices, transgenic animals.

Research Interests

We are interested in the mechanisms of regulation of neuronal gap junctions (electrical synapses) during development and neuronal injury. We also study the role of neuronal gap junctions in death of neurons in the developing nervous system and in the secondary, glutamate-dependent neuronal death following ischemic stroke, traumatic brain injury and epilepsy. As a result of these studies, a novel model of the mechanisms of glutamate-dependent neuronal death has been proposed, where neuronal gap junctions play a critical role.

Select Publications:

  • Arumugam H., Liu X., Colombo P.J., Corriveau R.A., Belousov A.B. NMDA receptors regulate developmental gap junction uncoupling via CREB signaling. Nature Neuroscience, 8 (12): 1720-1726, 2005. Abstract.
  • NEWS AND VIEWS: Nature Neuroscience, 8 (12): 1633-1634, 2005. Abstract.
  • IN THE NEWS: Nature Reviews Neuroscience, 7 (1): 8-9, 2006. Abstract.
  • deRivero Vaccari J.C., Corriveau R.A., Belousov A.B. Gap junctions are required for NMDA receptor-dependent cell death in developing neurons. Journal of Neurophysiology, 98 (5): 2878–2886, 2007. Abstract.
  • Wang Y., Denisova J.V., Kang K.S., Fontes J.D., Zhu B.T., Belousov A.B. Neuronal gap junctions are required for NMDA receptor-mediated excitotoxicity: implications in ischemic stroke. Journal of Neurophysiology, 104 (6): 3551-3556, 2010. Abstract.
  • Park W.-M., Wang Y., Park S., Denisova J.V., Fontes J.D., Belousov A.B. Interplay of chemical neurotransmitters regulates developmental increase in electrical synapses. The Journal of Neuroscience, 31 (16): 5909-5920, 2011. Abstract.
  • THIS WEEK IN THE JOURNAL: The Journal of Neuroscience, 31(16): i-i, 2011. Abstract.
  • Wang Y., Song J.-H., Denisova J.V., Park W.-M., Fontes J.D., Belousov A.B. Neuronal gap junction coupling is regulated by glutamate and plays critical role in cell death during neuronal injury. The Journal of Neuroscience, 32 (2): 713-725, 2012. Abstract.
  • THIS WEEK IN THE JOURNAL: The Journal of Neuroscience, 32 (2): i, 2012. Abstract.
  • Belousov A.B. Novel model for the mechanisms of glutamate-dependent excitotoxicity: role of neuronal gap junctions. Brain Research, 1487 (Special Issue: From Electrical Synapses to the Clinics: A Translational Perspective): 123-130, 2012. Abstract.
  • Belousov A.B., Fontes J.D. Neuronal gap junctions: making and breaking connections during development and injury. Trends in Neurosciences, 36 (4): 227-36, 2013. Abstract. 
  • Belousov A.B., Fontes J.D. Neuronal gap junction coupling as the primary determinant of the extent of glutamate-mediated excitotoxicity. Journal of Neural Transmission, 121 (8): 837-846, 2014. Abstract.
  • Fontes J.D., Ramsey J., Polk J.M., Koop A., Denisova J.V., Belousov, A.B. (2015) Death of neurons following injury requires conductive neuronal gap junction channels but not a specific connexin. PLOS ONE, 10 (5), e0125395, 2015. Abstract.
  • Belousov A.B., Nishimune H., Denisova J.V., Fontes J.D. (2017) On possible role of neuronal connexin 36 in amyotrophic lateral sclerosis progression. Neurosci Lett, 666, 1-4, 2017. Abstract.


Our Published Studies That Were Listed on PubMed Can Be Found Here:

http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/41503121/?sort=date&direction=descending