The research in Nagareddy lab is broadly focused on defining the pathological basis for enhanced atherothrombotic risk to various cardiovascular risk factors such as diabetes, obesity, cigarette smoking, high salt diet, rheumatoid arthritis etc. We specifically focus on identifying the inflammatory cues/ signaling mediators that interact with hematopoietic stem and progenitor cells in the bone marrow that promote systemic inflammation. Our major emphasis is on innate immune cells, particularly the neutrophils that have the ability not only to instigate inflammation but also facilitate the resolution of inflammation. We have identified certain neutrophil-derived alarmin molecules such as S100A8 and S100A9 that activate the NLRP3 inflammasome to initiate inflammation while also retaining the ability to induce anti-inflammatory signaling mechanisms. We use various animal models, human samples, invitro and ex vivo techniques to address our research questions. Our short-term goal is to validate and repurpose certain FDA-approved agents to target chronic inflammation and improve cardiometabolic outcomes. The long-term goal is to harness the wealth of knowledge from our studies and others to develop novel therapeutic strategies to reduce the overall burden of cardiovascular and cardiometabolic diseases. Our research is supported by both federal (NIH) and foundation grants (AHA).
Academic Section(s):
Cardiovascular Diseases
Education:
1993-1997: B. Pharm, Bangalore University, Bangalore, India
1999-2011: M. Pharm, Rajiv Gandhi University of Health Sciences, Bangalore, India
2002-2004: MSc, University of British Columbia, Vancouver, BC, Canada
2005-2009: PhD, University of British Columbia, Vancouver, BC, Canada
2009-2012: Post Doc, Columbia University, New York, NY, USA
2012-2016: Post Doc, University of Kentucky, Lexington, KY, USA
Board Certification(s):
FPGEC
Clinical/Research Interests:
Cardiovascular Risk Factors (Obesity, Diabetes, Smoking, High Salt Diet, RA etc.) and Aberrant Hematopoiesis
Neutrophils in Myocardial Infarction and Heart Failure
Myelopoiesis and Thrombopoiesis, Inflammation, Inflammasome and DAMPs
Adipose Tissue Inflammation, Insulin Resistance and Diabetes
Platelet Production and Function in Diabetes
Neutrophils in Pancreatic Islets and Beta Cell Loss
High Salt Diet, Th17 Cells, Gut Microbiome, Hematopoiesis and Atherosclerosis
Clonal Hematopoiesis and Atherosclerosis
Funding:
NIH Funding: https://reporter.nih.gov/search/J843ctCXLESirnUXqAuqKg/projects
ORCID: https://orcid.org/0000-0002-0294-641X
Select Honors & Accomplishments:
2020 Elected, Fellow of the American Heart Association, BCVS (FAHA)
2018 Young Investigator Award (Finalist), ISHR, Canada
2017 Kenneth M. Brinkhous Young Investigator Prize in Thrombosis (Finalist), ATVB/PVD, AHA
2015 Dean’s Distinguished Lecture Award, College of Medicine, University of Kentucky (UK)
2015 Outstanding Post-Doctoral Presentation- Gill Heart Institute Cardiovascular Research Day
2015 Young Investigators Award- at American College of Cardiology (Kentucky Chapter)
2015 Outstanding Early Career Award, (Finalist) at BCVS 2015, AHA Scientific Sessions
2015 Irvine H. Page Young Investigator Research Award (Finalist), ATVB/PVD, AHA
2014 Stew Whitman Memorial Award- Cardiovascular Research Day (UK)
2014 Best Research Presentation- Barnstable Brown Obesity and Diabetes Research Day (UK)
2014 CIHR (The Canadian Institutes of Health Research)-ICS Travel Award
2014 Best Poster Presentation, College of Medicine (UK)
2014 Stew Whitman Memorial Award- Cardiovascular Research Day (UK)
2013 Vasculata Scholarship- North American Vascular Biology Organization (NAVBO)
2013 Best Research Presentation- Barnstable Brown Obesity and Diabetes Research Day (UK)
2012 Have a Heart Award- Canadian Cardiovascular Society, Toronto, Canada
2012 CIHR-ICS Travel Award- Young Investigators Forum, Montreal, Canada
2012 Future of Science Fund Scholarship- Keystone Conference, Montana
2011 Young Investigator Award – ATVB Council, AHA, Chicago
2010 Post-Doctoral Research Fellowship from CIHR (3 years), Canada
2010 Early Career Investigator Award, The Kern Aspen Lipid Conference, Aspen, CO
2008 Peter Dresel Award- The IXth World Conference on Clinical Pharmacology & Therapeutics
2008 Graduate Student Travel Award – Canadian Society for Clinical Pharmacology, Canada
2008 Graduate Student Travel Award- Experimental Biology (ASPET)
2007 Subhash C. Verma Prize for best research published article in Pharma. Sciences, UBC,
2006 Heart and Stroke Foundation Travel Award, Young Investigators Forum, Canada
2006 Doctoral Research Award, Heart and Stroke Foundation of Canada (3 Years)
2006 Doctoral Research Award, Canadian Diabetes Association (3 Years)
2006 Doctoral Research Award, The Michael Smith Foundation for Health Research (3 Years)
2004 The John H McNeill Prize- UBC, Vancouver, Canada
2004 Graduate Research Scholarship in Pharmacy, CIHR and Rx & D (2 Years), Canada
Select Publications:
OUHSC Profile: https://profiles.ouhsc.edu/display/8464330
Publications: https://pubmed.ncbi.nlm.nih.gov/?term=nagareddy+pr&sort=date
ORCID: https://orcid.org/0000-0002-0294-641X