Beatriz Ferran Perez, PhD

Assistant Professor of Research

Department of Biochemistry & Physiology

Harold Hamm Health Campus at the University of Oklahoma
975 NE 10th St, BRC 1364, Oklahoma City, OK 73104

(405) 271-5921

Education:

2016   PhD in Biomedicine       University of Barcelona, Spain
2012   MSc in Biomedicine       University of Barcelona, Spain
2007   BSc in Biochemistry       University of Havana, Cuba

Clinical/Research Interests:

My research interests include the redox communication between astrocytes and neurons, and the role of protein glutathionylation in regulating the metabolic capacity of neural cells to cope with and recover from excitotoxic and neurometabolic insults. I am particularly interested in harnessing the activity of Glutaredoxin-1 to elicit cellular resilience to neurodegeneration.

Select Publications:

Ferrán B, Rose HM, Gray J, Redwine TL, Pham S, Rubin O, Rice HC, Sonntag WE, Díaz-García CM. Insulin regulates activity-dependent mitochondrial depolarization and calcium dynamics in dentate granule cells. J Neurosci. 2026 Oct 19:e0291262026. doi: 10.1523/JNEUROSCI.0291-26.2026. PMID: 42896895.

Rosen PC, Fu P, Ferrán B, Kim E, Brooks DJ, Lim DC, Díaz-García CM, Yellen G. Activity-dependent citrate dynamics in neurons. Proc Natl Acad Sci U S A. 2025 Oct 14;122(41):e2519902122. doi: 10.1073/pnas.2519902122. PMID: 41071660; PMCID: PMC12541437.

Gray J, Halemirle G, Ferrán B, Rose H, Redwine TL, Pham S, Hagy B, Pranay A, Giorgione J, Hussong SA, Galvan V, Humphries K, Van Remmen H, Kinter M, Sonntag WE, Singh PK, Díaz-García CM. Mitochondrial Ca²⁺ uniporter haploinsufficiency leads to sexually dimorphic redox imbalance and metabolic remodeling in the mouse brain. J Physiol. 2025 Oct 9. doi: 10.1113/JP287618. PMID: 41066222.

Matsui R, Ferran B, Oh A, Croteau D, Shao D, Han J, Pimentel DR, Bachschmid MM. Redox Regulation via Glutaredoxin-1 and Protein S-Glutathionylation. Antioxid Redox Signal. 2020 Apr 1;32(10):677-700. doi: 10.1089/ars.2019.7963. PMID: 31813265; PMCID: PMC7047114.

Kimura T*, Ferran B*, Tsukahara Y, Shang Q, Desai S, Fedoce A, Pimentel DR, Luptak I, Adachi T, Ido Y, Matsui R, Bachschmid MM. Production of adeno-associated virus vectors for in vitro and in vivo applications. Sci Rep. 2019 Sep 19;9(1):13601. doi: 10.1038/s41598-019-49624-w. PMID: 31537820; PMCID: PMC6753157. *Equal contribution.

Link to full publication list:

https://www.ncbi.nlm.nih.gov/myncbi/beatriz.ferran%20perez.1/bibliography/public/