Hongyi Zhou, PhD

Assistant Professor of Research

Department of Biochemistry & Physiology

940 Stanton L. Young Blvd, BMSB 938
Oklahoma City, OK 73104

405-271-2274

Education:

2000 - MS in Pharmaceutical Science, Tongji Medical College, Huazhong University of Science and Technology, China
2003 - PhD in Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, China
2005 - Postdoctoral training, Institute of Materia Medica, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, China
2011 - Postdoctoral training, The University of Texas M. D. Anderson Cancer Center

Funding:

05/01/2024-04/30/2028 NIDDK R01DK135657A1
Role: Co-I
Title: Novel Posttranslational Modifications in Adipose Biology

Select Honors and Accomplishments:

07/01/2018-06/30/2021 American Heart Association Career Development Award
Role: PI
Title: Neddylation in adipose tissue development and obesity

Select Publications:

1. Zhou H, Lei X, Yan Y, Lydic T, Li J, Weintraub NL, Su H, Chen W. Targeting ATGL to rescue BSCL2 lipodystrophy and its associated cardiomyopathy. JCI Insight. 2019 Jun 11;5(14) PubMed Central PMCID: PMC6675548.

2. Zhou H, Su H, Chen W. Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation. Int J Mol Sci. 2021 Sep 1;22(17) PubMed Central PMCID: PMC8431717.

3. Zhou H, Li J, Su H, Li J, Lydic TA, Young ME, Chen W. BSCL2/Seipin deficiency in hearts causes cardiac energy deficit and dysfunction via inducing excessive lipid catabolism. Clin Transl Med. 2022 Apr;12(4):e736. PubMed Central PMCID: PMC8982503.

4. Zhou H, Patel V, Rice R, Lee R, Kim HW, Weintraub NL, Su H, Chen W. Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation. Cells. 2024 Oct 5;13(19) PubMed Central PMCID: PMC11475318.

5. Zhou H, Chakraborty S, Zhao X, Weintraub NL, Su H, Chen W. COP9 signalosome is required for adipose tissue maintenance and metabolic health. J Lipid Res. 2026 Feb;67(2):100977. PubMed Central PMCID: PMC12887410.

Link to full publication list:
https://www.ncbi.nlm.nih.gov/myncbi/hongyi.zhou.1/bibliography/public/