Education:
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Postdoctoral Training in Adipose Tissue Metabolism, Wayne State University
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Postdoctoral training in Aging and Metabolism, University of Wisconsin-Madison
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PhD in Pharmacology and Toxicology, Michigan State University
East Lansing, MI
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Bachelor's Degree in Veterinary Science, Madras Veterinary College, Chennai, India
Clinical/Research Interests:
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Understanding the role of endothelial senescence in age-related vascular cognitive impairment.
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Targeting adipose tissue thermogenesis for vascular cognitive impairment in aging.
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Mechanisms of accelerated aging in cancer survivors focusing on the long-term effects of chemotherapy.
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Adipose-skeletal muscle crosstalk as a target for sarcopenia.
"My research focuses on understanding the therapeutic potential of adipose tissue thermogenesis or increased cellular expenditure for age-related diseases, specifically vascular cognitive impairment, and sarcopenia. I'm interested in understanding the mechanisms mediating the beneficial effects of favorable remodeling of adipose tissue by thermogenic stimulation on systemic metabolism, inflammation, and microvascular endothelial function. Research efforts will also be focused on gleaning novel insights into the endocrine actions of adipose tissue secreted lipid bioactive molecules on the microvasculature in aging. Emerging evidence suggests that cancer survivors who underwent chemotherapy suffer from an early onset of age-related diseases indicating an accelerated aging phenotype. We will investigate how the hallmarks of aging can be targeted for accelerated aging in cancer survivors."
Select Publications:
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Obesity-induced cognitive impairment in older adults: a microvascular perspective, 2021
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Aging is associated with glial senescence in the brainstem - implications for age-related sympathetic overactivity, 2021
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Single-cell RNA sequencing identifies senescent cerebromicrovascular endothelial cells in the aged mouse brain, 2020
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Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential, 2017
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Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic ß3-adrenergic receptor activation, 2014
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