The research in Nagareddy lab is broadly focused on defining the pathological basis for enhanced atherothrombotic risk to various cardiovascular risk factors such as diabetes, obesity, cigarette smoking, high salt diet, rheumatoid arthritis etc. We specifically focus on identifying the inflammatory cues/ signaling mediators that interact with hematopoietic stem and progenitor cells in the bone marrow that promote systemic inflammation. Our major to emphasis is on innate immune cells, particularly the neutrophils that have the ability not only to instigate inflammation but also facilitate the resolution of inflammation. We have identified certain neutrophil-derived alarmin molecules such as S100A8 and S100A9 that activate the NLRP3 inflammasome to initiate inflammation while also retaining the ability to induce anti-inflammatory signaling mechanisms. We use various animal models, human samples, invitro and ex vivo techniques to address our research questions. Our short-term goal is to validate and repurpose certain FDA-approved agents to target chronic inflammation and improve cardiometabolic outcomes. The long-term goal is to harness the wealth of knowledge from our studies and others to develop novel therapeutic strategies to reduce the overall burden of cardiovascular and cardiometabolic diseases. Our research is supported by both federal (NIH) and foundation grants (AHA).
Academic Section(s):
Cardiovascular Diseases
Education:
- 1993-1997: B. Pharm, Bangalore University, Bangalore, India
- 1999-2011: M. Pharm, Rajiv Gandhi University of Health Sciences, Bangalore, India
- 2002-2004: MSc, University of British Columbia, Vancouver, BC, Canada
- 2005-2009: PhD, University of British Columbia, Vancouver, BC, Canada
- 2009-2012: Post Doc, Columbia University, New York, NY, USA
- 2012-2016: Post Doc, University of Kentucky, Lexington, KY, USA
Board Certification(s):
Clinical/Research Interests:
- Cardiovascular Risk Factors (Obesity, Diabetes, Smoking, High Salt Diet, RA etc.) and Aberrant Hematopoiesis
- Neutrophils in Myocardial Infarction and Heart Failure
- Myelopoiesis and Thrombopoiesis, Inflammation, Inflammasome and DAMPs
- Adipose Tissue Inflammation, Insulin Resistance and Diabetes
- Platelet Production and Function in Diabetes
- Neutrophils in Pancreatic Islets and Beta Cell Loss
- High Salt Diet, Th17 Cells, Gut Microbiome, Hematopoiesis and Atherosclerosis
- Clonal Hematopoiesis and Atherosclerosis
OUHSC Profile: https://profiles.ouhsc.edu/display/8464330
ORCID: https://orcid.org/0000-0002-0294-641X
Funding:
NIH: https://reporter.nih.gov/search/J843ctCXLESirnUXqAuqKg/projects
Select Honors & Accomplishments:
- 2020: Elected, Fellow of the American Heart Association, BCVS (FAHA)
- 2018: Young Investigator Award (Finalist), ISHR, Canada
- 2017: Kenneth M. Brinkhous Young Investigator Prize in Thrombosis (Finalist), ATVB/PVD, AHA
- 2015: Dean’s Distinguished Lecture Award, College of Medicine, University of Kentucky (UK)
- 2015: Outstanding Post-Doctoral Presentation- Gill Heart Institute Cardiovascular Research Day
- 2015: Young Investigators Award- at American College of Cardiology (Kentucky Chapter)
- 2015: Outstanding Early Career Award, (Finalist) at BCVS 2015, AHA Scientific Sessions
- 2015: Irvine H. Page Young Investigator Research Award (Finalist), ATVB/PVD, AHA
- 2014: Stew Whitman Memorial Award- Cardiovascular Research Day (UK)
- 2014: Best Research Presentation- Barnstable Brown Obesity and Diabetes Research Day (UK)
- 2014: CIHR (The Canadian Institutes of Health Research)-ICS Travel Award
- 2014: Best Poster Presentation, College of Medicine (UK)
- 2014: Stew Whitman Memorial Award- Cardiovascular Research Day (UK)
- 2013: Vasculata Scholarship- North American Vascular Biology Organization (NAVBO)
- 2013: Best Research Presentation- Barnstable Brown Obesity and Diabetes Research Day (UK)
- 2012: Have a Heart Award- Canadian Cardiovascular Society, Toronto, Canada
- 2012: CIHR-ICS Travel Award- Young Investigators Forum, Montreal, Canada
- 2012: Future of Science Fund Scholarship- Keystone Conference, Montana
- 2011: Young Investigator Award – ATVB Council, AHA, Chicago
- 2010: Post-Doctoral Research Fellowship from CIHR (3 years), Canada
- 2010: Early Career Investigator Award, The Kern Aspen Lipid Conference, Aspen, CO
- 2008: Peter Dresel Award- The IXth World Conference on Clinical Pharmacology & Therapeutics
- 2008: Graduate Student Travel Award – Canadian Society for Clinical Pharmacology, Canada
- 2008: Graduate Student Travel Award- Experimental Biology (ASPET)
- 2007: Subhash C. Verma Prize for best research published article in Pharma. Sciences, UBC,
- 2006: Heart and Stroke Foundation Travel Award, Young Investigators Forum, Canada
- 2006: Doctoral Research Award, Heart and Stroke Foundation of Canada (3 Years)
- 2006: Doctoral Research Award, Canadian Diabetes Association (3 Years)
- 2006: Doctoral Research Award, The Michael Smith Foundation for Health Research (3 Years)
- 2004: The John H McNeill Prize- UBC, Vancouver, Canada
- 2004: Graduate Research Scholarship in Pharmacy, CIHR and Rx & D (2 Years), Canada
Select Publications:
https://pubmed.ncbi.nlm.nih.gov/?term=nagareddy+pr&sort=date