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Sangphil Oh, PhD
Cell Biology

Sangphil Oh, PhD

Assistant Professor of Research, Department of Cell Biology

975 NE 10th Street, BRC 1464
Oklahoma City, OK 73104

(405) 271-8001 Ext. 47419

Sangphil-Oh@ouhsc.edu

Education:

  • Ph.D. in Biological Sciences, Korea Advanced Institute of Science & Technology (KAIST), South Korea
  • M.S. in Biological Sciences, Korea Advanced Institute of Science & Technology (KAIST), South Korea
  • B.S. in Biological Sciences, Korea Advanced Institute of Science & Technology (KAIST), South Korea

Clinical/Research Interests:

Jumonji C domain-containing (JMJD) proteins are implicated in epigenetic regulation of gene expression mostly by demethylating lysine residues on histones. Based on recent findings, deregulation of JMJD proteins may be involved in the progression of diseases such as cancer, metabolic disorders and developmental defects. Out of the ~32 JMJD family members, we have identified several JMJD proteins which may function in cancer progression. Our lab focuses on how these JMJD proteins mechanistically regulate biological processes by using genetically engineered mouse models.

Select Publications:

  • Oh, S., Shin, S., Song, H., Grande, J.P., Janknecht, R. (2019) Relationship between ETS Transcription Factor ETV1 and TGF-β-regulated SMAD Proteins in Prostate Cancer. Sci. Rep. 9, 8186.
  • Oh, S., Shin, S., Janknecht, R. (2019). The small members of the JMJD protein family: Enzymatic jewels or jinxes? Biochim. Biophys. Acta - Reviews on Cancer 1871, 406-418.
  • Saran, A.R., Kalinowska, D., Oh, S., Janknecht, R., Ditacchio, L. (2018). JMJD5 links CRY1 function and proteasomal degradation. PLoS Biol. 16, e2006145.
  • Li, X., Oh, S., Song, H., Shin, S., Zhang, B., Freeman, W., Janknecht, R. (2018). A potential common role of the Jumonji C domain-containing 1A histone demethylase and chromatin remodeler ATRX in promoting colon cancer. Oncol. Lett. 16, 6652-6662.
  • Liu, H., Wang*, C., Lee*, S., Deng*, Y., Wither*, M., Oh*, S., Ning, F., Dege, C., Zhang, Q., Liu, X., Johnson, A.M., Zang, J., Chen, Z., Janknecht, R., Hansen, K., Marrack, P., Li, C.Y., Kappler, J.W., Hagman, J., and Zhang, G. (2017). Clipping of arginine-methylated histone tails by JMJD5 and JMJD7. Proc. Natl. Acad. Sci. 114. E7717-E7726. * These authors contributed equally to this work.
  • Kim, T.D., Oh, S., Lightfoot, S.A., Shin, S., Wren, J.D., and Janknecht, R. (2016). Upregulation of PSMD10 caused by the JMJD2A histone demethylase. Int. J. Clin. Exp. Med. 9, 10123-10134.
  • Kim, T.D., Jin, F., Shin, S., Oh, S., Lightfoot, S.A., Grande, J.P., Johnson, A.J., van Deursen, J.M., Wren, J.D., and Janknecht, R. (2016). Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1. J. Clin. Invest. 126, 706-720.
  • Oh, S., Shin, S., Lightfoot, S.A., and Janknecht, R. (2013). 14-3-3 proteins modulate the ETS transcription factor ETV1 in prostate cancer. Cancer Res. 73, 5110-5119.
  • Oh, S., Shin, S., and Janknecht, R. (2012). ETV1, 4 and 5: an oncogenic subfamily of ETS transcription factors. Biochim. Biophys. Acta - Reviews on Cancer 1826, 1-12.
  • Oh, S., and Janknecht, R. (2012). Histone demethylase JMJD5 is essential for embryonic development. Biochem. Biophys. Res. Commun. 420, 61-65.
  • Song, H., Oh, S., Oh, H.J., and Lim, D.S. (2010). Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity. Biochem. Biophys. Res. Commun. 391, 969-973.
  • Choi*, J., Oh*, S., Lee, D., Oh, H.J., Park, J.Y., Lee, S.B., and Lim, D.S. (2009). Mst1-FoxO signaling protects Naive T lymphocytes from cellular oxidative stress in mice. PLoS One 4, e8011. * These authors contributed equally to this work.
  • Oh*, S., Lee*, D., Kim*, T., Kim, T.S., Oh, H.J., Hwang, C.Y., Kong, Y.Y., Kwon, K.S., and Lim, D.S. (2009). Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. Mol. Cell. Biol. 29, 6309-6320.

* These authors contributed equally to this work.

Complete List of Published Work in My NCBI: 
https://www.ncbi.nlm.nih.gov/myncbi/1vUjydy4nw-kr/bibliography/public/