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David Dyer, PhD
Microbiology & Immunology

David Dyer, PhD

Professor Emeritus

Office: BRC 1106

David-Dyer@ou.edu

Academic Section(s):

Microbiology and Immunology

Education:

Ph.D. - 1983, Kansas State University

Fellowship:

University of North Carolina at Chapel Hill; The State University of New York at Buffalo

Clinical/Research Interests:

David W. Dyer received a B.S in Biology at Emporia State University in 1975, a Ph.D. in Microbiology at Kansas State University in 1983, and followed with postdoctoral studies at the University of North Carolina at Chapel Hill. Dr. Dyer moved to the State University of New York at Buffalo as an Assistant Professor in 1988. In 1995, Dr. Dyer joined the Department of Microbiology and Immunology at the University of Oklahoma Health Sciences Center. Rising to the rank of Professor, Dr. Dyer retired in 2024 and joined the emeritus faculty. Dr. Dyer's expertise is primarily in Gram-negative bacterial physiology, metabolism, mechanisms of pathogenesis and microbial genomics. He has a longstanding interest in microbial iron metabolism, having studied iron uptake systems in a variety of bacterial systems. These studies have lately included extensive analyses of global gene expression patterns in Neisseria gonorrhoeae using a variety of technologies, most recently employing whole transcriptome RNA-seq, sRNA-seq and GRIL-Seq analysis. Upon arriving at OUHSC in 1995, Dr. Dyer began to move into microbial genomics, and participated in the sequencing and analysis of the genomes of Neisseria gonorrhoeae, Aggregatibacter actinomycetemcomitans, 10 additional bacterial pathogens and over 40 human adenovirus isolates. Currently, Dr. Dyer is Co-Director of the Data Science Core for the Oklahoma IDeA Network of Biomedical Research Excellence (OK-INBRE, P20GM103447), having held this position since the inception of the INBRE program in 2001. In this capacity, Dr. Dyer also has contributed to the bioinformatics analyses of data obtained from bacterial, human, rat and mouse RNA-seq analysis, microbial ecology, phylogenetic analysis, pathway analysis and comparative genomics. The tools and analysis pipelines developed with over 30 years of experience in microbial genomics and microbiomics are readily available upon request.

Select Publications:

  • Chavez-Bueno S, M. Day M, I. Toby, D. Akins, and D.W. Dyer. May/June 2014. Genome Sequence of SCB34, a Sequence Type 131, Multidrug-Resistance Escherichia coli Isolate Causing Neonatal Early-Onset Sepsis. Genome Announc. 2(3):00514-14. doi:10.1128/genomeA.00514-14. PMID: 24926049
  • Day M, Ibrahim M, Dyer D, Bulla L, Jr. July/August 2014. Genome sequence of Bacillus thuringiensis subsp. kurstaki strain HD-1. Genome Announc. 2(4):e00613-14. doi:10.1128/genomeA.00613-14. PMID: 25035322
  • Toby, I., and D.W. Dyer. Divergence of protein-coding capacity and regulation in the Bacillus cereus sensu lato group. BMC Bioinformatics 2014, 15(Suppl 11):S8 (21 October 2014) PMID: 25350501
  • Day, M.W., L.A. Jackson, D.R. Akins, D.W. Dyer and S. Chavez-Bueno. Whole Genome Sequences of the Archetypal K1 Escherichia coli Neonatal Isolate RS218, and the Contemporary Neonatal Bacteremia Isolates SCB11, SCB12, and SCB15. Genome Announc. January/February 2015 3:e01598-14; doi:10.1128/genomeA.01598-14. PMID: 25720688
  • Ramke, M., J.Y. Lee, D.W. Dyer, D. Seto, J. Rajaiya, and J. Chodosh. The 5’ UTR of human adenoviruses: new insights into evolution and leader diversity. Virology. 2015 Nov;485:452-9. doi: 10.1016/j.virol.2015.08.018.
  • Singh, G., X. Zhou, J.Y. Lee, M. Yousuf, M. Ramke, M. Ismail, J. Lee, C. Robinson, D. Seto, D. Dyer, M. Jones, J. Rajaiya, and J. Chodosh. Recombination of the Epsilon Determinant and Corneal Tropism: Human Adenovirus Species D types 15, 29, 56, and 69. Virology. 2015 Nov;485:452-9. doi: 10.1016/j.virol.2015.08.018. Epub 2015 Sep 7. PMID: 26343864
  • Kenedy, M.R., E.J. Scott II, B. Shrestha, A. Anand, H. Iqbal, J.D. Radolf, D.W. Dyer and D.R. Akins. Consensus Computational Network Analysis for Identifying Candidate Outer Membrane Proteins from Borrelia Spirochetes. BMC Microbiology BMC Microbiology 16: 141 (2016); DOI 10.1186/s12866-016-0762-z.
  • Ismail, A.M., J. Lee, D.W. Dyer, D. Seto, J. Rajaiya and J. Chodosh. Selection Pressure in the Human Adenovirus Fiber Knob Drives Cell Specificity in Epidemic Keratoconjunctivitis. J Virol. 2016 Oct 14;90(21):9598-9607. Print 2016 Nov 1.
  • Chavez-Bueno, S., B. coli, M. Iliki, D. Akins, D. Dyer, D. Bard and E. Scott II. Route of Infection Alters Virulence of Neonatal Septicemia Escherichia coli Clinical Isolates. PLOS ONE, December 13, 2017 https://doi.org/10.1371/journal.pone.0189032
  • Jackson, L., M. Day, J. Allen, E. Scott II, and D.W. Dyer. Iron-Regulated Small RNA Expression as Neisseria gonorrhoeae FA_1090 Transitions into Stationary Phase Growth. BMC Genomics 18: 317, 2017; DOI: 10.1186/s12864-017-3684-8.
  • Day, M., E. Scott II, L. Jackson and D.W. Dyer. ChIP-seq analysis of Fur binding and the Iron Response Regulon of Neisseria gonorrhoeae FA1090. BMC Genomics (submitted).
  • Jackson, L.A., M. Day, E. Scott II, J. Allen and D.W. Dyer. Transcriptome analysis of Neisseria gonorrhoeae FA1090 grown under iron-limiting conditions. BMC Genomics (submitted).