OMRF is a non-profit organization that was founded in 1946 with the mission of conducting basic biomedical research to help people live longer, healthier lives. Scientists at the OMRF are dedicated to understanding and curing human disease and focus on such critical research areas as lupus, multiple sclerosis, heart disease, cancer and Alzheimer's disease. Many of the subspecialty attendings and residents hold positions at the OMRF and the VA and/or OUMI. 

In 2019, OU Medical Center and Stephenson earned a highly coveted US News and World Report Top 50 “Best Hospitals for Cancer” ranking, placing it in the Top 1% of all hospitals in the nation for cancer care. Stephenson Cancer Center supports 135 member investigators who conduct state-of-the-art research in the basic, clinical, behavioral and population sciences on the OU Health Sciences Center and OU Norman campuses. Residents have the opportunity to work closely with clinical and research faculty at the Stephenson Cancer Center throughout their training. 

OU Medical Center is the only comprehensive academic hospital in the state and is home to Oklahoma’s only Level I trauma center. OU Medical Center offers the highest level of care for stroke patients and is home to Oklahoma’s most experienced organ transplant team, only comprehensive bone marrow transplant center, and more radiation therapy options than any hospital in Oklahoma. From advanced cardiac care, vascular procedures, OU Medical Center patients benefit from healthcare based on the latest research and advances in medicine. Residents are exposed to a wide variety of patients and pathologies.

Harold Hamm Diabetes Center is among the world’s largest and most comprehensive institutions focusing on all aspects of diabetes care, prevention, research, and training. Harold Hamm has facilities in Oklahoma City and Tulsa as well as affiliated sites across the state, including partnerships with Native American communities. Hamm Diabetes Center's research group is one of the top-funded and largest in the world. Endocrinologists based out of Harold Hamm also staff an inpatient consult service and dedicate time to teaching residents throughout their training.

OU is home to the states most comprehensive Children’s Hospital. The Children’s Hospital also houses the Women’s and Newborn center where internal medicine residents may be call to help manage expectant mothers with various medical conditions. Residents also utilize the ample conference space in the Samis Education Center, located in the Children’s Hospital

OU Physicians is the state's largest physician group and encompasses almost every adult specialty. OU Physicians have expertise in the management of complex conditions that is unavailable elsewhere in the state, region or sometimes even the nation. Residents have the opportunity to rotate through many different outpatient subspecialty clinics as well as gain exposure to general outpatient internal medicine at OU Physicians