The Heart Rhythm Institute pursues a broad-based research program in cardiac arrhythmias that includes basic and clinical investigation. This comprehensive program has produced important discoveries and advances by including scientists and clinicians from many fields, including cardiology, electrophysiology, immunology, cell biology and pharmacology. The synergism produced by discussion, accessibility, and cross-pollination of many disciplines has resulted in significant contributions to the field.
Some of HRI's current research includes: 
- Grant from Presbyterian Health Foundation for studying the role of surviving myocardial bundles within the infarct scar in ischemia induced ventricular tachycardia/fibrillation.
- Grant from Stereotaxis Corporation investigating magnetic navigation system for electrophysiological mapping.
- Grant from the National Institutes of Health titled "Towards a Non-Invasive Therapy for Atrial Fibrillation."
- Grant from Cardiofocus for a clinical study for the endoscopic ablation system.
- Grant from Cardiofocus Corporation for the study of light ring balloon catheter - atrial fibrillation.
- Grant from Atricure Corporation for thoracoscopically-assisted epicardial bilateral pulmonary vein isolation for atrial fibrillation.
- Grant from Biosense Webster for endocardial ablation of typical atrial flutter and a clinical study for ablation in patients with ventricular tachycardia.
- Grant from CV Therapeutics for a pharmacological approach to atrial fibrillation.
- Grant from Endosense to evaluate a contact sensor catheter for ablation.
- Grant from Johnson & Johnson for pharmacological study for subjects with non-valvular atrial fibrillation.
- Grant from Reliant for pharmacological study for the prevention of recurrent, symptomatic atrial fibrillation.
- Grants from ProRhythm Corporation for focused ultrasound for the treatment of atrial fibrillation.