Academic Section(s):
Endocrinology and Diabetes
Education:
- 1990 Doctor of Medicine, Shandong Medical University, Shandong, China
Fellowship:
- 1996 - 1999 Post-doctoral Research Fellow, Endocrinology, Diabetes and Metabolism, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Clinical/Research Interests:
Research Interests
- GRK2 and proteasome dysregulation in myocardial ischemia.
- Altered autonomic signaling in diabetic cardiomyopathy.
- G-protein receptor autoimmunity in cardiovascular diseases.
Select Publications:
Li H, Guo Y, Zhang G, Deng J, Fischer H, Craig LB, Yu X, Kem DC. Gonadotrophin-releasing hormone receptor autoantibodies induce polycystic ovary syndrome-like features in a rat model. Exp Physiol 2021;106(4):902-912.
Li H, Zhang G, Guo Y, Deng J, Fischer H, Craig LB, Kem DC, Yu X. Autoimmune activation of the GnRH receptor induces insulin resistance independent of obesity in a female rat model. Physiol Rep 2021;8(24):e14672.
Weedin EA, Burks HR, Yu X, Li H, Aston CE, Kem DC, Craig LB. Elevated activity levels of activating autoantibodies to the gonadotropin releasing hormone receptor in patients with polycystic ovary syndrome. F&S Rep 2020;1(3):299-304.
Kem DC, Li H, Yu X, Weedin E, Reynolds AC, Forsythe E, Beel M, Fischer H, Hines B, Guo Y, Deng J, Liles JT, Nuss Z, Elkosseifi M, Aston CE, Burks HR, Craig LB. The role of GnRH receptor autoantibodies in polycystic ovary syndrome. J Endocr Soc 2020;4(8):bvaa078.
Badiudeen T, Forsythe EA, Bennett G, Li H, Yu X, Beel M, Nuss Z, Blick KE, Okamoto LE, Arnold AC, Paranjape SY, Black BK, Maxey C, Kem DC, Raj SR. A functional cell-based bioassay for assessing adrenergic autoantibody activity in postural tachycardia syndrome. J Transl Autoimmun 2019;2:100006.
Li H, Zhang G, Zhou L, Nuss Z, Beel M, Hines B, Murphy T, Liles J, Zhang L, Kem DC, Yu X. Adrenergic autoantibody-induced postural tachycardia syndrome in rabbits. J Am Heart Assoc 2019;8(19):e013006.
Yu X, Li H, Murphy TA, Nuss Z, Liles J, Liles C, Aston CE, Raj SR, Fedorowski A, Kem DC. Angiotensin II type 1 receptor autoantibodies in postural tachycardia syndrome. J Am Heart Assoc 2018;7(8):e008351.
Fedorowski A, Li H, Yu X, Koelsch KA, Harris VM, Liles C, Murphy TA, Quadri SM, Scofield RH, Sutton R, Melander O, Kem DC. Antiadrenergic autoimmunity in postural tachycardia syndrome. Europace 2017;19(7):1211-1219.
Li H, Murphy T, Zhang L, Huang B, Veitla V, Scherlag BJ, Kem DC, Yu X. b1-adrenergic and M2 muscarinic autoantibodies and thyroid hormone facilitate induction of atrial fibrillation in male rabbits. Endocrinology 2016;157(1):16-22.
Li H, Zhang L, Huang B, Veitla V, Scherlag BJ, Cunningham MW, Aston CE, Kem DC, Yu X. A peptidomimetic inhibitor suppresses the inducibility of b1-adrenergic autoantibody-mediated cardiac arrhythmias in the rabbit. J Interv Card Electrophysiol 2015;44(3):205-212.
Liles C, Li H, Veitla V, Liles JT, Murphy TA, Cunningham MW, Yu X, Kem DC. AT2R autoantibodies block angiotensin II and AT1R autoantibody-induced vasoconstriction. Hypertension 2015;66(4):830-835.
Galloway A, Li H, Vanderlinde-Wood M, Khan M, Benbrook A, Liles C, Zillner C, Rao V, Cunningham MW, Yu X, Kem DC. Activating autoantibodies to the b1/2-adrenergic and M2 muscarinic receptors associate with atrial tachyarrhythmias in patients with hyperthyroidism. Endocrine 2015;49(2):457-463.
Li H, Kem DC, Zhang L, Huang B, Liles C, Benbrook A, Gali H, Veitla V, Scherlag BJ, Cunningham MW, Yu X. Novel retro-inverso peptide inhibitor reverses angiotensin receptor autoantibody-induced hypertension in the rabbit. Hypertension 2015;65(4):793-799.
Li H, Yu X, Cicala MV, Mantero F, Benbrook A, Veitla V, Cunningham MW, Kem DC. Prevalence of angiotensin II type 1 receptor (AT1R)-activating
autoantibodies in primary aldosteronism. J Am Soc Hypertens 2015;9(1):15-20.
Li H, Scherlag BJ, Kem DC, Benbrook A, Zhang L, Huang B, Cunningham MW, Lazzara R,Yu X. Atrial tachyarrhythmias induced by the combined effects of b1/2-adrenergic autoantibodies and thyroid hormone in the rabbit. J Cardiovasc Transl Res 2014;7(6):581-589.
Kem DC, Li H, Velarde-Miranda C, Liles C, Vanderlinde-Wood M, Galloway A, Khan M, Zillner C, Benbrook A, Rao V, Gomez-Sanchez CE, Cunningham MW, Yu X. Autoimmune mechanisms activating the angiotensin AT1 receptor in ‘primary’ aldosteronism. J Clin Endocrinol Metab 2014;99(5):1790-1797.
Li H, Yu X, Liles C, Khan M, Vanderlinde-Wood M, Galloway A, Zillner C, Benbrook A, Reim, S, Collier D, Hill MA, Raj SR, Okamoto LE, Cunningham MW, Aston CE, Kem DC. Autoimmune basis for postural tachycardia syndrome. J Am Heart Assoc 2014;3(1):e000755.
Li H, Scherlag BJ, Kem DC, Benbrook A, Shen X, Cunningham MW, Lazzara R, Aston CE, Yu X. Inducible cardiac arrhythmias caused by enhanced b1-adrenergic autoantibody expression in the rabbit. Am J Physiol Heart Circ Physiol 2014;306(3):H422-428.
Li H, Scherlag BJ, Kem DC, Zillner C, Male S, Thirunavukkarasu S, Shen X, Benbrook A, Pitha JV, Lazzara R, Yu X. The propensity for inducing atrial fibrillation: a comparative study in old versus young rabbits. J Aging Res 2014;2014:684918.
Li H, Zuccolo J, Kem DC, Zillner C, Lee J, Smith K, James JA, Cunningham MW, Yu X. Implications of a vasodilatory human monoclonal autoantibody in postural hypotension. J Biol Chem 2013;288(42):30734-30741.
Li H, Yu X. Emerging role of JNK in insulin resistance. Curr Diabetes Rev 2013;9(5):422-428.
Li H, Scherlag BJ, Kem DC, Zillner C, Male S, Thirunavukkarasu S, Shen X, Pitha JV, Cunningham MW, Lazzara R, Yu X. Atrial tachycardia provoked in the presence of activating autoantibodies to β2-adrenergic receptor in the rabbit. Heart Rhythm 2013;10(3):436-441.
Li H, Kem DC, Reim S, Khan M, Vanderlinde-Wood M, Zillner C, Collier D, Liles C, Hill MA, Cunningham MW, Aston CE, Yu X. Agonistic autoantibodies as vasodilators in orthostatic hypotension: a new mechanism. Hypertension 2012;59(2):402-408.
Yu X, Stavrakis S, Hill MA, Huang S, Reim, S, Li H, Khan M, Hamlett SR, Cunningham MW, Kem DC. Autoantibody activation of beta-adrenergic and muscarinic receptors contributes to an "autoimmune" orthostatic hypotension. J Am Soc Hypertens 2012;6(1):40-47.
Stavrakis S, Kem DC, Patterson E, Lozano P, Huang S, Szabo B, Cunningham MW, Yu X. Opposing cardiac effects of autoantibody activation of β-adrenergic and M2 muscarinic receptors in cardiac related diseases. Int J Cardiol 2011;148(3):331-336.
Yu X, Kem DC. Proteasome inhibition during myocardial infarction. Cardiovasc Res 2010;85(2):312-320.
Stavrakis S, Yu X, Patterson E, Huang S, Hamlett SR, Chalmers L, Pappy R, Cunningham MW, Morshed SA, Davies TF, Lazzara R, Kem DC. Activating autoantibodies to the beta1-adrenergic and M2 muscarinic receptors facilitate atrial fibrillation in patients with Graves’ hyperthyroidism. J Am Coll Cardiol 2009;54(14):1309-1316.
Yu X, Patterson E, Kem DC. Targeting proteasomes for cardioprotection. Curr Opin Pharmacol 2009;9(2):167-172.
Yu X, Patterson E, Stavrakis S, Huang S, De Aos I, Hamlett S, Cunningham MW, Lazarra R, Kem DC. Development of cardiomyopathy and atrial tachyarrhythmias associated with activating autoantibodies to beta-adrenergic and muscarinic receptors.J Am Soc Hypertens 2009;3(2):133-140.
Mascaro-Blanco A, Alvarez K, Yu X, Lindenfeld J, Olansky L, Lyons T, Duvall D, Heuser JS, Gosmanova A, Rubenstein CJ, Cooper LT, Kem DC, Cunningham MW. Consequences of unlocking the cardiac myosin molecule in human myocarditis and cardiomyopathies. Autoimmunity 2008;41(6):442-453.
Huang S, Patterson E, Yu X, Garrett MW, Kem DC. Proteasome inhibition one hour following ischemia protects GRK2 and prevents malignant ventricular tachyarrhythmias and SCD in a canine model of myocardial infarction. Am J Physiol Heart Circ Physiol 2008;294(3):H1298-1303.
Yu X, Tesiram YA, Towner RA, Abbott A, Patterson E, Huang S, Garrett MW, Chandrasekaran S, Matsuzaki S, Szweda LI, Gordon BE, Kem DC. Early myocardial dysfunction in streptozotocin-induced diabetic mice: a study using in vivo magnetic resonance imaging (MRI). Cardiovasc Diabetol 2007;6:6.
Kem DC, Metcalf JP, Cornea A, Dunnam M, Engelbrecht A, Yu X. Is pseudocushings syndrome in a critically ill patient pseudo? Endocr Pract 2007;13(2):153-158.
Kem DC, Yu X, Patterson E, Huang S, Stavrakis S, Szabo B, Olansky L, McCauley J, Cunningham MW. An autoimmune hypertensive syndrome. Hypertension 2007;50(5):829-834.
Patterson E, Yu X, Huang S, Garrett MW, Kem DC. Suppression of autonomic-mediated triggered firing in pulmonary veins, 24 hrs post coronary artery ligation in the dog. J Cardiovasc Electrophysiol 2006;17(7):763-770.
Yu X, Patterson E, Huang S, Garrett MW, Kem DC. Tumor necrosis factor alpha, rapid ventricular tachyarrhythmias and infarct size in canine models of myocardial infarction. J Cardiovasc Pharmacol 2005;45(2):153-159.
Yu X, Huang S, Patterson E, Garrett MW, Kaufman KM, Metcalf JP, Zhu M, Dunn ST, Kem DC. Proteasome degradation of GRK2 during ischemia and ventricular tachyarrhythmias in a canine model of myocardial infarction. Am J Physiol Heart Circ Physiol 2005;289(5):H1960-1967.
Kem DC, Lyons DF, Wenzl J, Halverstadt D, Yu X. Renin-dependent hypertension caused by nonfocal stenotic aberrant renal arteries: proof of a new syndrome. Hypertension 2005;46(2):380-385.
Castro OL, Yu X, Kem DC. Diagnostic value of the post-captopril test in primary aldosteronism. Hypertension 2002;39(4):935-938.
Yu X, Zhang M, Kyker K, Patterson E, Benovic JL, Kem DC. Ischemic inactivation of G protein-coupled receptor kinase and altered desensitization of canine cardiac b-adrenergic receptors. Circulation 2000;102(20):2535-2540.