https://medicine.ouhsc.edu/academic-departments Parent Page: Academic Departments id: 33472 Active Page: Facultyid:33475

Faculty

Jacob E. "Jed" Friedman, PhD
Biochemistry and Physiology

Jacob "Jed" E Friedman, PhD

Director, Harold Hamm Diabetes Center

Associate Vice Provost for Diabetes Programs, OUHSC

Chickasaw Professor, Department of Biochemistry & Physiology, OUHSC College of Medicine

Adjunct Professor, Department of Pediatrics

Jed-Friedman@ou.edu

From left to right: Keenan Greyslak, PhD; Rachel Janssen, MS; Jacob E. "Jed" Friedman, PhD; Ram Badu Undi, PhD; Ben Nelson, PhD

Clinical/Research Interests:

1. Maternal Obesity/GDM and Developmental programming in Infant Stem Cells and Neonatal health.

2. The Microbiome role in development of Pediatric Metabolic Associated Steatotic Liver Disease (MASLD).

3. Social determinants of Health and Maternal Health Equity to reduce  Morbidity and Mortality in Native Americans.

4. Nutritional intervention and Epigenetic determinants of health in mouse, monkey, and man.

Funding:

ACTIVE RESEARCH SUPPORT: (Total Direct Costs):

1. NIH-R01-DK121951-01 MPI: (Friedman (contact)/Jonscher): “Role of the macrophage in developmentally programmed NAFLD” $2,316,960. 07/01/2020 – 06/30/2025. -1 yr NCE.

2. NIH-R01-DK128416-01- Friedman, PI “Maternal Obesity and Pediatric NAFLD: Fetal Origins and Long-term outcomes in Non-Human Primates” $1,821,034. 09/01/2021 – 08/31/2025.

3. NIH-R01-DK128187-01 MPI: (Friedman, Kievit contact PI): “Metformin in Pregnancy: Fetal Consequences & Long-term Offspring Outcomes in a NHP Model” $8,447,463. 09/01/2021 – 08/31/2026.

4. NIH R01-DK129656-01 MPI: (Friedman, Short-contact PI): “Understanding the metabolic pathology of pediatric obesity and NAFLD” $2,535,684, 04/01/2022 – 03/30/2026.

5. NIH-R01-DK131064-01 (Li, PI, Friedman, Co-I) “Sulfur amino acid metabolism and regulation of hepatic metabolic flexibility” $1,504,168. 01/01/2022 –12/31/2026.

6. NIH R01 DK129948-01 (Li, PI, Friedman, Co-I). “Novel Roles of Cullin-RING E3 Ligases in Liver Pathophysiology”. $1,493,313. 10/1/2023 – 09/30/27.

7. NIH-U54-HD113173. MPI: (Friedman/Shreffler-Contact PI/Spicer/VanWagoner). “Center for Indigenous Resilience, Culture, and Maternal Health Equity.” $10,448,621. 8/17/2023 – 7/31/2030.

8. NIH-R01DK122028-06 (Joshi, PI, Friedman, Co-I) “Novel mechanism of aryl hydrocarbon receptor-mediated differential gene regulation”. $$1,812,500. 4/1/2024-3/30/2028.

9. NIH-R01DK139443-01 MPI: (Jonscher, Myers, Friedman, Consultant). “Evaluating PQQ for preventing maternal obesity-induced fetal programming of juvenile NAFLD in Papio anubisbis”. $2,094,746. 3/1/2024-2/28/2028.

10. NIH-R01DK138986-01 (Jiang, PI, Friedman, Consultant). “Macrophage miR-130b/301b and beige adipogenesis” $2,256,225. 5/1/2024-3/30/2029.

11. Burroughs Wellcome Fund- Next Generation Pregnancy Initiative:(Hayes, PI, Friedman, Co-I) “Promoting resilience against the effects of maternal inflammation on developmental programming of microglia in the offspring”. $300,000. 6/2024-5/2028.

LOCAL GRANTS:

12. HHDC Team Science Grant (Pierce, PI, Friedman Co-I): “Pilot RCT Intervention Targeting Elevated Triglycerides with a Point-of-Care Meter and Omega-3 Fatty Acids to Normalize Triglycerides and Fetal Growth” $638,000. 7/1/2020 – 6/30/2026.

13. HHDC pilot award: (Short, PI, Friedman, Co-I) Maternal obesity and diet: Impact on liver and metabolic health during pregnancy and post-partum. $150,000, 07/1/2023-6/30/2025.

Select Honors and Accomplishments:

  • 2025, Nominated for The University of Oklahoma David L. Boren Professorship for outstanding teaching, research and creative activity, and leadership in professional and public service.
  • 2023, NIH- Workshop Organizer/Speaker: Multigenerational Nutrition Influences on Health and Disease.
  • 2022, Keystone Conference Session Chair, Inter Organ Crosstalk in Non-Alcoholic Steatohepatitis (NASH).
  • 2019, Endowed Chair and Director, Harold Hamm Diabetes Center, University of Oklahoma
  • 2018-present Danish Diabetes Academy and Novo Nordisk International Committee for Talent Development.
  • 2018, Co-Chair and Organizer, 40th Annual Kern-Aspen Lipid Conference, Vail, Colorado.
  • 2017, Sir Harcourt Caughey Award-University of Auckland, NZ for Visiting Distinguished International faculty.
  • 2017, Co-Chair, NIH Working Group on Obesity and Environmental Influences on Child Health Outcomes ECHO cohort.
  • 2014, American Diabetes Association Norbert Freinkel Award for outstanding contributions to the field of diabetes and pregnancy.
  • 2014, Post-Doc Mentor of the Year award, University of Colorado Anschutz Medical Campus.
  • 2014, American Diabetes Association Michaela Modan Memorial Award - for top abstract in human epidemiology, complications, and prevention of diabetes.

Select Publications:

1. Friedman JE. Developmental Programming in Gestational Diabetes in Mouse, Monkey, and Man, Where do we go next? –The Norbert Freinkel Lecture. Diabetes Care, 38(8):1402-11, 2015 PMID: 26207051

2. Wesolowski SR, el Kasmi K, Jonscher K, and Friedman JE. Developmental programming of NAFLD: A womb with a clue. Nature Reviews: Gastroenterology and Hepatology 14(2):81-96, 2016. PMID: 27780972.

3. Soderborg TK, Mulligan C, Babcock L, Janssen R, Johnson L, Frank D, Weir T, Barbour LA, Severs E, D’alessandro A, El-Kasmi KE, and Friedman JE. The gut microbiota in infants of obese mothers Increases inflammation and susceptibility to obesity and NAFLD. Nature Communications, 26;9(1): 4462, 2018, PMID: 30367045

4. Nash MJ, Dobrinskikh E, Soderborg TK, Janssen RC, Takahashi DL, Dean T, Varlamov O, Stouffer RE, Gannon M, Aagaard KM, McCurdy CE, Kievit P, Bergman B, Jones KL, Pietras EM, Wesolowski SR, and Friedman JE*. Maternal diet induces long term innate immune cell memory through hematopoietic

stem and progenitor cells in Non-Human Primate offspring. Cell Reports 42(4):112393, 2023. PMID: 37058409

5. Sugino KY, Hernandez TL, Barbour LA, Kofonow JM, Daniel N. Frank DN, and Friedman JE. Distinct serum metabolomic and gut microbiome profiles after GDM diet treatment: Implications for personalized dietary interventions. Microorganisms 12(7):1369, 2024. PMID: 39065137.

Complete List of Published Work in My Bibliography:

https://www.ncbi.nlm.nih.gov/myncbi/jacob.friedman.1/bibliography/public/