In-office gynecologic procedures such as intrauterine device (IUD) insertion, endometrial biopsy (EMB), and manual vacuum aspiration (MVA) are essential components of reproductive healthcare but are frequently associated with significant patient discomfort, particularly among nulliparous patients and adolescents. Evidence supports several strategies to reduce procedural pain, including local anesthetic techniques such as paracervical or intracervical lidocaine blocks, intrauterine anesthetic instillation, and the use of nonsteroidal anti-inflammatory drugs. In addition, patient-centered approaches—including anticipatory counseling and trauma-informed care—can improve the overall procedural experience. Despite this growing body of evidence, pain management practices for in-office gynecologic procedures remain inconsistent across clinical settings. Quality improvement initiatives aimed at implementing evidence-based pain management strategies may help improve patient comfort and promote more consistent patient-centered care.