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Kris Sekar, MD

Kris Sekar, MD


1200 North Everett Drive; ETNP 7504
Oklahoma City, OK 73104


MyNCBI Publicatons

Academic Section(s):

Neonatal-Perinatal Medicine


Madras Medical College, University of Madras, Madras, India MD - 1974 
Pediatric Residency: Polyclinic Medical Center, Harrisburg, PA - 1979 
Pediatric Residency, Chief Resident: Georgetown University Hospital, Washington, DC - 1981 
Neonatology Fellowship: Georgetown University Hospital, Washington, DC - 1983 
Training in ECMO: Children's National Medical Center, George Washington University, Washington DC
Lean Six-Sigma Green Belt: University of Oklahoma, Norman, OK

Board Certification(s):

American Board of Pediatrics
American Board of Pediatrics Sub-Specialty Boards
Neonatal Perinatal Medicine

Clinical/Research Interests:

Pulmonary Physiology
Non- invasive Ventilation
Surfactant therapy
Inhaled Nitric Oxide
Quality Improvement


Mallinckrodt Pharmaceuticals
Multicenter, Prospectively Defined Observational Registry with Retrospective Data Collection, Evaluating Premature and Term-Near-Term Neonates with Pulmonary Hypertension Receiving Inhaled Nitric Oxide via Invasive or Noninvasive Ventilator Support at US Centers
K C Sekar, Principle Investigator

A multicenter, double blind, randomized, single dose, active-controlled study to investigate the efficacy and safety of synthetic surfactant (chf 5633) in comparison to porcine surfactant (poractant alfa, curosurf®) in the treatment of preterm neonates with respiratory distress syndrome
K C Sekar, Principle Investigator

Pediatric Pharmacy Advocacy Group 
Comparison of amikacin pharmacokinetics in neonates pre- and post-doing protocol change.
Primary investigator: Miller JL (PI)

Co-Investigators: Hughes KM, Anderson MP, Sekar KC, Johnson, PN

Potential use of inhaled nitric oxide (iNO) as an adjunct to neonatal resuscitation protocol
KC Sekar, Principal investigator

Pfizer Paraxel
A multi-centre, randomized, placebo-controlled, double-blind, two-armed, parallel group study to evaluate efficacy and safety of iv sildenafil in the treatment of neonates with persistent pulmonary hypertension of the newborn (PPHN) or hypoxic respiratory failure and at risk for PPHN
KC Sekar, Principal investigator

National Institute of Health, NHLBI
Grant #   5R01HL069991-02
“Prolonged Outcome after Nitric Oxide (PrONOx)
Multicenter trial (Derek Angus, PI, University of Pittsburgh)

KC Sekar, Principal Investigator, OUHSC

National Institute of Health - NHLBI
Grant # 1UO1HL64857-01A1 "Inhaled Nitric Oxide for the Prevention of Chronic Lung Disease" Multicenter Trial (Dr. John Kinsella, PI, University of Colorado)
KC Sekar, Principal Investigator, University of Oklahoma

Select Publications:

  • Sekar K, Szyld E, McCoy M, Wlodaver A, Dannaway D, Helmbrecht A, Riley J, Manfredo A, Anderson M, Lakshminrusimha S, Noori S. Inhaled nitric oxide as an adjunct to neonatal resuscitation in premature infants: a pilot, double blind, randomized controlled trial. Pediatr Res. 2020 Feb;87(3):523-528. doi: 10.1038/s41390-019-0643-x. Epub 2019 Oct 30. PMID: 31666688
  • Ganguly A, Makkar A, Sekar K. Volume Targeted Ventilation and High Frequency Ventilation as the Primary Modes of Respiratory Support for ELBW Babies: What Does the Evidence Say? Front Pediatr. 2020 Feb 7;8:27. doi: 10.3389/fped.2020.00027. eCollection 2020. PMID: 32117833
  • Ramanathan R, Biniwale M, Sekar K, Hanna N, Golombek S, Bhatia J, Naylor M, Fabbri L, Varoli G, Santoro D, Del Buono D, Piccinno A, Dammann CE. Synthetic Surfactant CHF5633 Compared with Poractant Alfa in the Treatment of Neonatal Respiratory Distress Syndrome: A Multicenter, Double-Blind, Randomized, Controlled Clinical Trial.J Pediatr. 2020 Jun 14:S0022-3476(20)30725-3. doi: 10.1016/j.jpeds.2020.06.024. Online ahead of print. PMID: 3255386
  • Makkar A, Siatkowski RM, Szyld E, Ganguly A, Sekar K.C Scope of telemedicine in neonatology. hongguo Dang Dai Er Ke Za Zhi. 2020 May;22(5):396-408. doi: 10.7499/j.issn.1008-8830.2001135. PMID: 32434631
  • Sekar K, Fuentes D, Krukas-Hampel MR, Ernst FR. Health Economics and Outcomes of Surfactant Treatments for Respiratory Distress Syndrome Among Preterm Infants in US Level III/IV Neonatal Intensive Care Units. J Pediatr Pharmacol Ther. 2019 Mar-Apr;24(2):117-127. doi: 10.5863/1551-6776-24.2.117.
    PMID: 31019404