Hospital Location:
1200 North Everett Drive; ETNP 7504
Oklahoma City, OK 73104

Lab Location:
800 Research Parkway, Office No. 462
Oklahoma City, OK 73104

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Academic Section(s):

Neonatal-Perinatal

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Education:

Medical School: NRS Medical College & Hospital, Kolkata, West Bengal, India
Residency: Jackson Memorial Hospital - University of Miami, Flordia
Fellowship: Rainbow Babies & Children's Hospital - Case Western Reserve University, Cleveland, Ohio

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Board Certification(s):

Board-certified for General Pediatrics, American Board of Pediatrics
Board-certified for Neonatal-Perinatal Medicine

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Clinical/Research Interests:

Survivors of extremely preterm birth suffer from high levels of respiratory infections, asthma-like symptoms, and early onset chronic obstructive pulmonary disease (COPD). As a neonatologist and a physician-scientist, my long-term research goal is to study and prevent these life-long respiratory morbidities which affect extremely preterm infants. My research program aims to define the role of oxidative stress modulators as an interface between environmental oxidative injury (e.g., hyperoxia exposure) and the molecular programming which drive postnatal differentiation, barrier function and repair in the epithelial lining of small and large airways in newborn babies. We use in vitro organotypic air-liquid interface (ALI) culture models with supplemental oxygen exposure, to study the effects of oxidative stress on airway epithelial programming. Along with animal models of hyperoxic lung injury, we utilize neonatal tracheal aspirate-derived primary epithelial stem cells for organotypic cultures, thus closely mimicking a developing neonatal airway exposed to postnatal oxidative stress. Our lab is currently supported by funding from the Presbyterian Health Foundation (PHF) and Oklahoma Shared Clinical and Translational Resources (OSCTR).

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Select Honors & Accomplishments:

2018 - 2019: William Randolph Hearst research fellow in Neonatology, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, OH, USA
2019: Travel award for Pediatric Academic Society 2019, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, OH, USA
2018: Program representative for the NICHD Clinician Scientist Investigators Meeting, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Potomac, MD, USA
2018: Travel award for the 92nd Perinatal and Developmental Medicine Symposium, Academy of Pediatrics (AAP), Aspen, CO, USA 
2018: Travel award & finalist, 5th Annual Neonatal Cardiopulmonary Biology: Young investigator Forum, Chicago, IL, USA
2004: Scholastic award, West Bengal Board of Higher Secondary Education, Kolkata, West Bengal, India

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Select Publications:

• Ganguly A, Ofman G, Vitiello PF. Hydrogen Sulfide-Clues from Evolution and Implication for Neonatal Respiratory Diseases. Children (Basel). 2021 Mar 11;8(3):213. doi: 10.3390/children8030213. PMID: 33799529; PMCID: PMC7999351.

• Ganguly A, Martin RJ. Vulnerability of the developing airway. Respir Physiol Neurobiol. 2019 Dec;270:103263. PubMed PMID: 31386914.

• Ganguly A, Makkar A, Sekar K. Volume Targeted Ventilation and High Frequency Ventilation as the Primary Modes of Respiratory Support for ELBW Babies: What Does the Evidence Say?. Front Pediatr. 2020;8:27. PubMed PMID: 32117833; PubMed Central PMCID: PMC7025474.