https://medicine.ouhsc.edu/academic-departments Parent Page: Academic Departments id: 23109 Active Page: Our Teamid:23118

Section Leadership

Trent Tipple, MD

Trent E Tipple, MD

Professor and Section Chief, Section of Neonatal-Perinatal Medicine
Adjunct Professor of Nutrition Physiology, Biochemistry& Molecular Biology
Children's Health Foundation Reba McEntire Endowed Chair in Neonatology

Medical and Operational Leadership

Jeffrey Eckert, PhD
Pediatrics

Jeffrey Eckert, PhD

Director of Lab Research
Assistant Professor of Research


941 Stanton L. Young Blvd. 
Basic Sciences Education Building, Room 235
Oklahoma City, Oklahoma 73104

405-271-5215

Jeffery-Eckert@ouhsc.edu


As a member of the Chaaban laboratory, Dr. Eckert implemented a model of and neonatal necrotizing enterocolitis (NEC), and has focused in developing other experimental models through which to study diseases of NIH pre-doctoral training fellowship/scholarship intestinal inflammation. A recent focus has includes exploring acute kidney injury (AKI) in NEC.  In addition, Dr. Eckert assists with multiple translation projects, clinical studies, and is a co-director for the biorepository.


MyNCBI Publications

Fun Fact: "My high school mascot has been featured on Scooby Doo."


Academic Section(s):

Neonatal-Perinatal


Education:

Ph.D. - Medical College of Wisconsin Department of Physiology (Center for Human Molecular Genetics), Milwaukee, WI
Postdoctoral Fellowship - University of Oklahoma Health Sciences Center, Oklahoma City, OK


Clinical/Research Interests:

The Chaaban laboratory works to elucidate the mechanisms through which glycosaminoglycans (GAGs), biologically active components of breast milk, may be protective against intestinal inflammation generally, and neonatal necrotizing enterocolitis (NEC). Research in the Chaaban laboratory has focused on the many risk factors at play in predisposing infants to developing NEC, including extensive use of antibiotics, lack of breastfeeding, disrupted intestinal microbiome, and the developmentally immature interface between the immune system and the intestinal epithelium in the neonate. Both rodent models and in vitro systems are utilized to further investigate specific attributes of many of these risk factors in the hope that effective therapeutic strategies against NEC and associated diseases will surface.
Recent work has begun to explore AKI in NEC. Recent data from human and animal studies show that approximately 12% of preterm infants develop AKI, defined by a raise in serum creatinine from a previous low. In two independent studies, 50% of infants who developed NEC stage 2 or above developed kidney injury with more severe NEC identified as a risk factor for AKI. Interestingly, AKI was an independent risk factor for mortality, demonstrating that AKI in NEC patients is not a silent player but actually an active contributor to worse outcomes.  We are working to determine the extent of acute renal injury will be observed in the Paneth cell ablation model of NEC.  NEC leads to a systemic inflammatory response not only in the gut but also possibly in the kidney.  We are exploring the kidney damage within our NEC model exploring histological injury, inflammation and disruption of tight junction proteins.  In addition, we are also exploring pathways of inflammation and metabolism within the kidney in a NEC model.


Select Honors & Accomplishments:

2019 - Mentor Award Pediatrics Research Day
2017 - Mentor Award Pediatrics Research Day
2016 - Mentor Award Pediatrics Research Day
2015 - Mentor Award Pediatrics Research Day
2002-2006 - NIH pre-doctoral training fellowship/scholarship
2004 - NSF Research Experience for Undergraduates (REU)


Select Publications:

  • Chaaban H, Burge K, Eckert J, Keshari R, Silasi-Mansat R, Lupu C, Warner B, Escobedo M, Caplan M, Lupu F. Neutrophil extracellular trap inhibition increases inflammation, bacteremia, and mortality in murine necrotizing enterocolitis. J Cell Molec Med (Online Ahead of Print), 2020. PMID 32515131.
  • Eckert J, Scott B, Lawrence SM, Ihnat M, Chaaban H.  FLLL32, a curcumin analog, ameliorates intestinal injury in necrotizing enterocolitis. J Inflamm Res. 2017 Jun 14;10:75-81. PMID: 28652797
  • Gunasekaran A, Eckert J, Burge K, Zheng W, Yu Z, Kessler S, de la Motte C, Chaaban H. Hyaluronan 35 kDa enhances epithelial barrier function and protects against the development of murine necrotizing enterocolitis. Ped Res 87(7), 177-1184, 2019. PMID 31499514. PMC7061074.



Educational Leadership

Erynn Bergner, MD

Erynn Bergner, MD

Assistant Professor
Associate Fellowship Program Director, Section of Neonatal-Perinatal Medicine

Douglas Dannaway, MD

Doug Dannaway, MD

Director of Fellowship
Associate Professor, Section of Neonatal-Perinatal Medicine

Netsanet Kassa, MD

Netsanet Kassa, MD

Assistant Professor
Director of Resident Education, Section of Neonatal-Perinatal Medicine

Research Leadership

Hala Chaaban, MD

​Hala Chaaban, MD

Associate Professor
Adjunct Professor of Nutrition
Associate Director of Translational Research, Section of Neonatal-Perinatal Medicine

Edgardo Szyld, MD, MSc

Edgardo Szyld, MD, MSc

Professor of Research
Director of Clinical and Translational Research Section of Neonatal-Perinatal Medicine
Associate Vice-Chair of Education, Department of Pediatrics

Peter Vitiello, PhD

Peter Vitiello, PhD

Associate Professor
Adjunct Professor of Physiology, Biochemistry & Molecular Biology
Director of Laboratory Research, Section of Neonatal-Perinatal Medicine

Faculty

Lora Bailey-Downs, PhD

Lora Bailey-Downs, PhD

Assistant Professor

Faizah Bhatti, MD

Faizah Bhatti, MD

Associate Professor
Adjunct Associate Professor of Ophthalmology
Member, Oklahoma Center for Neurosciences

Sara Brewer, DO

Sara Brewer, DO

Assistant Professor of Pediatrics, Neonatal-Perinatal Medicine

Kathryn Burge, PhD

Kathryn Burge, PhD

Assistant Professor of Research

Jeffrey Eckert, PhD

Jeffrey Eckert, PhD

Director of Lab Research
Assistant Professor of Research

Jolyn Fernandes, PhD

Jolyn Fernandes, MS, PhD

Assistant Professor of Pediatrics
Associate Director of Metabolomics, Laboratory for Molecular Biology and Cytometry Research
Adjunct Assistant Professor, Biochemistry and Molecular Biology
Member, Harold Hamm Diabetes Center

Arlen Foulks, DO

Arlen Foulks, DO

Assistant Professor
Medical Director of NeoFlight Neonatal Transport Service
Assistant Medical Director, Level 2 NICU at St. Anthony Hospital
Chair of American Osteopathic Board of Pediatrics (AOBP)
Chair of the Neonatal Exam Committee on the AOBP
Adjunct Clinical Assistance Professor in Pediatrics at OSU College of Osteopathic Medicine and Center of Health Sciences

Abhrajit Ganguly, MD

Abhrajit Ganguly, MD

Assistant Professor

Vadim Ivanov, MD

Vadim Ivanov, MD

Assistant Professor
Assistant Medical Director of CCMH NICU
Neonatologist

Erin Jain, MD

Erin Jain, MD

Clinical Assistant Professor
Pediatrician

Barbara Johnson, MD

Barbara Johnson, MD

Assistant Professor
Assistant Director of NICU Resident Education

Samuel Levin, MD

Samuel Levin, MD

Clinical Assistant Professor
 

Marjorie Makoni, MD

Marjorie Makoni, MD

Assistant Professor
Neonatologist

Maxwell Mathias, MD

Maxwell Mathias, MD

Assistant Professor of Pediatrics

Raja Nandyal, MD

Raja Nandyal, MD

Professor of Pediatrics
Medical Director Oklahoma Infant Transition Program (OITP)
Medical Director of Oklahoma Transition Clinic (OTC)
Chairman of OUHSC Neonatal Mortality Committee (NMC)

Gaston Ofman, MD

Gaston Ofman, MD

Assistant Professor

Rita Raman, MD, MS, CNS, JD, MACN, FCLM

Rita Raman, MD, MS, CNS, JD, MACN, FCLM

Professor
Neonatologist

Tavleen Sandhu, MD

Tavleen Sandhu, MD

Clinical Assistant Professor of Pediatrics, Neonatal-Perinatal Medicine
Associate Director of NeoFlight Neonatal Transport Service

Kris Sekar, MD

Kris Sekar, MD

Professor
Neonatologist

Birju Shah, MD, MPH, MBA

Birju Shah, MD, MPH, MBA

Associate Professor
Neonatologist

Frederico Vieira, MD

Frederico Vieira, MD

Assistant Professor

Lauren White, DO

Lauren White, DO

Clinical Assistant Professor
Medical Director of Transition and Labor Consults
Neonatologist

Anne Wlodaver, MD

Anne Wlodaver, MD

Clinical Associate Professor of Pediatrics
Medical Director of SAH Level II NICU