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Residency Faculty

Family and Preventive Medicine

Michael S. Businelle, PhD

Leader of the OTRC mHealth Core

Health Promotion Research Center
University of Oklahoma Health Sciences Center
655 Research Parkway, Suite 400
Oklahoma City, OK  73104

(405) 271-6872

Michael S. Businelle, PhD, is a Peggy and Charles Stephenson Endowed Chair in Cancer, Co-Director of the TSET Health Promotion Research Center (previously Oklahoma Tobacco Research Center), and Professor (tenured) in the Department of Family and Preventive Medicine at OU Medicine. He is also the founding director of the NCI-designated Stephenson Cancer Center mHealth Shared Resource.

Over the past five years, Businelle's team has developed the Insight mHealth platform, which enables researchers to rapidly create mobile applications that can utilize EMA and sensor data to identify environmental, cognitive, affective, physiological, and behavioral antecedents of health risk behaviors (e.g., smoking, heavy alcohol use, poor diet / inactivity / obesity, etc.) and deliver context-specific JITAIs in real-time. To date, Insight has supported over 60 studies (>30 with NIH funding).

Businelle is PI/MPI on six ongoing NIH-funded studies including mHealth applications that focus on smoking cessation, alcohol cessation, case management, anxiety/depression, and COVID-19 in cancer patients. His primary goal is to improve understanding of the causes of health disparities and to create and disseminate effective smartphone based just-in-time adaptive interventions (JITAIs) that reduce health disparities.

Academic Section(s):

OUFMC Research Division


The University of Texas MD Anderson Cancer Center, Houston, TX
Doctor of Philosophy in Clinical Psychology (APA Accredited; 2003-2007)

Louisiana State University, Baton Rouge, LA
Internship in Clinical Psychology (APA Accredited; 2006-2007)

The University of Mississippi Medical Center & G. V. (Sonny) Montgomery Veterans Affairs Medical Center, Jackson, MS
Master of Arts in Clinical Psychology (2001-2003)

Louisiana State University, Baton Rouge, LA
Experimental Psychology Masters Student (1999-2001)

University of Louisiana – Lafayette, Lafayette, LA
Bachelor of Science (1992-1996)

University of Southwestern Louisiana, Lafayette, LA


The University of Texas MD Anderson Cancer Center, Houston, TX
Postdoctoral Fellowship in Cancer Prevention Research (2007-2009)

Clinical/Research Interests:

  • Development of Novel Tobacco Cessation Interventions for Underserved/Disadvantaged Populations (e.g., Homeless Adults, Uninsured)
  • Using Technology to Identify Antecedents of Health Risk Behaviors
  • Technology Supported Health Behavior Change Interventions



Principal Investigator

R01MH126586 (MPIs: Businelle, Zvolensky)    05/01/2021 – 03/31/2024 
Mobile Health to Monitor Risk for COVID-19 and Improve Mental Health during the Pandemic
This study will evaluate the efficacy of the Easing Anxiety Sensitivity for Everyone (EASE) app (N=800) which includes COVID-19 symptom monitoring and intervention and targets anxiety sensitivity, a transdiagnostic individual difference factor implicated in the etiology, maintenance, and progression of anxiety and depressive symptoms. 

R01CA221819 (PI: Businelle)        02/01/2019 – 01/31/2024
NIH/NCI (Clinical Trials#: NCT03740490)
Smartphone Based Smoking Cessation Intervention for Socioeconomically Disadvantaged Adults
This study (N=450) will compare the longer-term effects of the Smart-T smoking cessation app with the free and publicly available NCI QuitGuide smoking cessation app (Aim 1). The second aim will determine if Smart-T messages that are tailored to address key smoking lapse risk variables in real-time (i.e., urge, stress, cigarette availability, cessation motivation) reduce participant ratings of these lapse risk variables compared with similar situations that do not receive this tailored content (QuitGuide group).

R01MD010733 (PIs: Businelle & Reingle)     09/26/2017 – 05/31/2022
NIH/NIMHD (Clinical Trials#: NCT03399500)
mHealth to Increase Service Utilization in Recently Incarcerated Homeless Adults
This 3-armed randomized clinical trial will use an innovative smartphone application to identify    and address barriers that prevent recently incarcerated homeless adults from obtaining available    case management, crisis management, substance abuse, and mental health services.

R34AA024584-02S1 (PIs: Businelle & Walters)     06/01/2020 – 05/31/2021
NIH/NIAAA (Clinical Trials#: NCT03746808)    
Supplement: Development and Testing of a Just-in-Time Adaptive Smart Phone Intervention to Reduce Drinking among Homeless Adults
The aim of this study is to provide additional support to complete the third phase of the study during the COVID-19 pandemic. Original study aims are to identify predictors of heavy drinking and develop and test a just-in-time adaptive intervention to prevent heavy drinking days in a sample of homeless adults with Alcohol Use Disorder.
Direct & Indirect: $128,617 (Direct: $88,094)

TSET R21-02 (PIs: Businelle & Kendzor)    07/01/2020 – 06/30/2023
Health Promotion Research Center
This grant funds the Health Promotion Research Center.

P30CA225520 Supplement (MPIs: Businelle & Moxley)    06/01/2020 – 05/31/2021
NIH/NCI (Clinical Trials#: NCT04397614)
Mobile Health Study and Enhanced Symptom Monitoring to Prevent Severe Illness from COVID-19 in Cancer Patients
The Symptom Tracker app will follow 500 patients who are receiving chemotherapy daily for 24 weeks. When COVID-19 symptoms are detected, the app assesses COVID-19 risk, provides information (e.g., locations of testing sites), and connects the patient health care professionals. When/if a patient tests positive for COVID-19, the app assess symptom severity each day and provides advice/connections when severe symptoms are detected.

U54MD015946 (PI: Obasi; Project MPIs: Businelle & Zvolensky)    09/01/2020 – 04/30/2025
Overall grant title: HEALTH Center for Addictions Research and Cancer Prevention
Core Project title: Improving access to cigarette cessation treatment among African American smokers: Development and evaluation of an integrated mHealth application

We will refine and evaluate an initially developed and tested, novel, mobile intervention that targets sensitivity to bodily sensations among African American smokers and bridges the gap in access to care which has plagued this health disparities population. 

OUHSC Pilot Funds  (PI: Businelle; NCT03405129)     06/01/2018 – 05/31/2022
Project Phoenix: Pilot Intervention for Smokers Who Are Not Ready to Quit Smoking
The primary long-term objective of this research is to increase smoking cessation attempts and reduce smoking relapse through the use of automated phase based mobile smoking cessation interventions. The primary short-term objective of this pilot study is to determine the initial utility of the novel Phoenix smartphone based smoking cessation app.

OUHSC Pilot Funds (PI: Businelle & Funk-Lawler; NCT04126642)     03/01/2020 – 05/31/2022
Project Persist: mHealth for Cancer Survivorship
This pilot randomized controlled trial (RCT) will assess the initial feasibility of a phone-delivered intervention for anxiety and depressive symptoms among cancer patients that are receiving active radiation treatments. A total of 60 participants will be randomized to in-person and smartphone-based assessment only (n=30) or assessment plus smartphone-based intervention (n=30). 


R01CA251451 (PI: Kendzor)   04/01/2021 – 03/31/2026 
Mobile Contingency Management for Smoking Cessation among Socioeconomically Disadvantaged Adults

R21CA253600/R33 (PI: Bui)     07/01/2020 – 06/30/2025
Mobile Health Technology for Personalized Tobacco Cessation Support in Laos

R01 DA046096-01 (PI: Cropsey)     07/15/2020 – 04/30/2025
Circadian and sleep mechanisms among racial groups for nicotine dependence, craving, and Withdrawal

R01CA243552 (PI: D. Vidrine)    09/01/2019 – 08/31/2024
Randomized Trial of Automated Video-Assisted Smoking Treatment for People Living with HIV

R01CA231952 (PIs: D. Vidrine & J. Vidrine)   04/01/2019 – 11/30/2024
Partnering with a State Food Bank to Provide Tobacco Treatment to Underserved Smokers

P30 CA225520 (PI: Mannel)     05/01/2018 – 04/30/2023
Stephenson Cancer Center – Cancer Center Support Grant
Dr. Businelle is the Scientific Director of the NCI designated Stephenson Cancer Center mHealth Shared Resource. The shared resource enables researchers to rapidly create mobile applications that identify environmental, cognitive, affective, physiological and behavioral antecedents of cancer risk behaviors (e.g., smoking, heavy alcohol use, poor diet, inactivity, obesity, etc.) and deliver context-specific adaptive interventions in real time.

R01CA197314 (PI: Kendzor)   07/08/2015 – 06/30/2021
Small Financial Incentives to Promote Smoking Cessation in Safety Net Hospital Patients

#IRG-19-142-01 (PI: McQuoid)     01/01/2021 – 12/31/2021
ACS-Institutional Research Grant
Piloting a Mobile Health mixed method to understand rural cancer risk-related substance use behaviors: combining smartphone data collection with qualitative mapping


K01 MD015295 (PI: Alexander)   05/08/2021 – 1/31/2026    
HealthyCells: A Culturally-Tailored Smoking Cessation Smartphone Intervention for African Americans with Adjunctive Treatment for Sedentary Behavior

R01CA221819-01A1S1 (PI: Businelle)   09/01/2019 – 01/31/2022
The Application of a Smartphone-Based Smoking Cessation Tool with American Indian Adults
This NCI Diversity Supplement will support Dr. Ashley Cole’s development into an independent reseacher. This study involves qualatative examination of ways the Smart-T3 app can be culturally tailored for American Indian smokers seeking smoking cessation treatment.

K01HL148907 (PI: Alayna P. Tackett)   08/21/2019 – 07/31/2024
Respiratory effects of E-Cigarette use among Youth: A prospective, longitudinal investigation

K99/R00DA046564 (PI: Emily Hébert)  R00 phase 08/01/2020 – 11/30/2023
Using Machine Learning to Develop Just-in-Time Adaptive Interventions for Smoking Cessation

F31DA047015 (PI: Samantha Schiavon)  07/01/2018 – 05/31/2021 
Balanced Placebo Design with Varenicline: Pharmacological and Expectancy Effects on Medication Adherence

F31DA052158 (PI: Michelle Sisson)   06/01/2020 – 05/31/2023
Increasing Naloxone Access for Persons who use Opioids: An Online Recruitment and Training Approach to Opioid Overdose Education and Naloxone Distribution

Select Publications:


  1. Zvolensky, M.J., Kauffman, B.Y., Garey, L., Buckner, J.D., Businelle, M.S., & Reitzel, L.R. (2022) Financial strain among adult African American/Black cannabis users. Journal of Ethnicity in Substance Abuse.  DOI: 10.1080/15332640.2022.2092924
  2. Ehlke, S.J., Cohn, A.M., Boozary, L., Alexander, A.C., Waring, J. C., Businelle, M. S., & Kendzor, D. (2022) Discrimination, substance use, and mental health among sexual and gender minority adults accessing day shelter services. Substance Use & Misuse; 57(8): 1237-1247. DOI: 10.1080/10826084.2022.2076874
  3. Businelle, M. S., Garey, L., Gallagher, M. W., Hébert, E.T., Vujanovic, A., Alexander, A., Kezbers, K., Matoska, C., Robison, J., Montgomery, A., & Zvolensky, M. J.  (2022) An integrated mHealth app for smoking cessation in Black smokers with anxiety: Protocol for a randomized controlled trial. JMIR Research Protocols; 11(5), e38905.
  4. Garey, L., Hébert, E. T., Mayorga, N. A., Chavez, F., Shepherd, J. M., Businelle, M., & Zvolensky, M. J. (2022) Evaluating the feasibility and acceptability of a mobile based health technology for smoking cessation: Mobile Anxiety Sensitivity Program (MASP). British Journal of Clinical Psychology;61 (Suppl 1):111-129. doi: 10.1111/bjc.12294
  5. Bui, T. C., Sopheab, H., Businelle, M. S, Chhea, C., Ly, P. S., Vidrine, J. I., Thol, D., Frank-Pearce, S. G., Vidrine, D. J. (2022) Mobile-health intervention for smoking cessation among Cambodian people living with HIV: A mixed-methods pilot study. AIDS Care;34(4):430-439. doi: 10.1080/09540121.2021.1887443
  6. Walters, S. T., Businelle, M. S., Suchting, R., *Li, X., *Hébert, E. T., & Mun, E-Y. (2021) Using machine learning to identify predictors of imminent drinking and create tailored messages for at-risk drinkers experiencing homelessness. Journal of Substance Abuse Treatment. Volume 127, 108417.
  7. Cropsey, K. L., Wolford-Clevenger, C., *Sisson, M. L., Chichester, K. R., Azuero, A., Businelle, M. S., Hendricks, P. S., Shelton, R. C., Carpenter, M. J. (2021) A pilot study of nicotine replacement therapy sampling and selection to increase medication adherence in low-income smokers. Nicotine & Tobacco Research; 18;23(9):1575-1583. doi: 10.1093/ntr/ntab029
  8. Mun, E-Y., *Li, X., Businelle, M. S., Tan, Z., Barnett, N. P., & Walters, S. T. (2021). Ecological momentary assessment of alcohol consumption and its concordance with transdermal alcohol detection and timeline follow-back self-report among adults experiencing homelessness. Alcoholism: Clinical and Experimental Research, 45, 864-876. 
  9. *Hébert, E. T., Suchting, R., *Ra, C. K., *Alexander, A. C., Kendzor, D. E., Vidrine, D. J., & §Businelle, M.S. (2021). Predicting the first smoking lapse during a quit attempt: A machine learning approach. Drug and Alcohol Dependence, 218, 108340. 
  10. Suchting, R., Businelle, M. S., Hwang, S. W., Padhye, N. S., Yang, Y., Santa-Maria, D. M. (2020). Predicting daily sheltering arrangements among youth experiencing homelessness using diary measurements collected by ecological momentary assessment. International Journal of Environmental Research and Public Health, 17, 6873.
  11. Kendzor, D. E., Businelle, M. S., Waring, J. J. C., Mathews, A., Geller, D. W., Barton, J. M., *Alexander, A. C., *Hébert, E. T., *Ra, C. K., Vidrine, D. J. (2020). Automated Mobile Delivery of Financial Incentives for Smoking Cessation among Socioeconomically Disadvantaged Adults: A Feasibility Study. JMIR mHealth and uHealth,8(4), e15960. DOI:
  12. Businelle, M. S. (co-first author), Walters, S. (co-first author), Mun, E-Y, Kirchner, T. R., *Hébert, E. T., & Li, X. (2020). Reducing Drinking Among People Experiencing Homelessness: Protocol for the Development and Testing of a Just-in-Time Adaptive Intervention. JMIR Research Protocols, 9, e15610. PMCID: 7193437 
  13. *Hébert, E. T., *Ra, C. K., *Alexander, A. C., Helt, A., Moisiuc, R., Kendzor, D. E., Vidrine, D. J., Funk-Lawler, R. K., §Businelle, M. S. (2020). A mobile just-in-time adaptive intervention for smoking cessation: pilot randomized controlled trial. Journal of Medical Internet Research, 22(3), e16907. PMCID: 7091024 
  14. *Cooper, M., *Case, K. R., *Hébert, E. T., Vandewater, E. A., Raese, K., Perry, C. L. & Businelle, M. S. (2019). Characterizing ENDS use in young adults with ecological momentary assessment: Results from a pilot study. Addictive Behaviors, 91, 30-36. PMC6364672
  15. Suchting, R., *Hébert, E. T., Ma, P., Kendzor, D. E., & §Businelle, M. S. (2019). Using elastic net penalized cox proportional hazards regression to identify predictors of imminent smoking lapse. Nicotine & Tobacco Research, 21, 173-179. PMID: 29059349

Research Faculty

Adam C. Alexander, PhD

Adam C. Alexander, PhD

Assistant Professor

Desiree Azizoddin, PsyD

Desiree Azizoddin, PsyD

Assistant Professor

Thanh C. Bui

Thanh C. Bui, MD, DrPH

Assistant Professor

Michael S. Businelle, PhD

Michael S. Businelle, PhD

Leader of the OTRC mHealth Core

Ann Chou, PhD, MPH

Ann Chou, PhD, MPH


Robert Hamm, PhD

Robert Hamm, PhD

Professor, Director of Medical Decision Making

Darla E. Kendzor, Ph.D.

Darla E. Kendzor, PhD

Associate Professor
Leader of the Tobacco Intervention Research Clinic

Amanda Kong, Assistant Professor

Amanda Kong, PhD, MPH

Assistant Professor

Julia McQuoid, PhD

Julia McQuoid, PhD

Assistant Professor

Natasha M. Mickel, Ph.D.

Natasha M. Mickel, PhD

Assistant Professor
Assistant Director of Faculty Development
Director of Oklahoma Center for Mentoring Excellence
Program Coordinator of Center for Telemedicine

Jim Mold, MPH, MD

Jim W. Mold, MPH, MD

Professor Emeritus
Member of the Institute of Medicine

Zsolt Nagykáldi, PhD

Zsolt J. Nagykáldi, PhD, BTh

Director of Research (OUFMC)
Associate Director of Community-Engaged Research (OSCTR)
Associate Director of the Oklahoma Primary Healthcare Improvement Collaborative (OPHIC)

Jordan Neil, PhD

Jordan Neil, PhD

Assistant Professor

Jason A. Oliver, PhD

Jason A. Oliver, PhD

Assistant Professor

Dewey Scheid, MD

Dewey Scheid, MD, MPH

Medical Decision Making



Elizabeth Wickersham, MD

Elizabeth Wickersham, MD, MS, CAQ-Hospice and Palliative Medicine

Associate Professor 
Associate Residency Program Director