https://medicine.ouhsc.edu/Academic-Departments Parent Page: Academic Departments id: 22046 Active Page: Faculty - Staffid:22079

Faculty and Staff

Faculty

Takemi Tanaka, Ph.D.
Pathology

Takemi Tanaka, Ph.D.

Associate Professor


The University of Oklahoma Health Sciences Center
Stephenson Cancer Center
975 NE 10th
BRC-W, 1415
Oklahoma City, OK 73104

405-271-8260

takemi-tanaka@ouhsc.edu


Fellowship:

  • Breast cancer metastasis and metastasis prevention
  • Anti-migration therapy for breast cancer treatment
  • Tumor inflammation
  • Identification of prognostic biomarker
  • Type II diabetes and immunity in cancer
  • Cancer health disparities


Select Publications:

  1. Tanaka T, Suh KS, Lo AM, De Luca LM. p21WAF1/CIP1 is a common transcriptional target of retinoid receptors:pleiotropic regulatory mechanism through RAR/RXR heterodimer and RXR/RXR homodimer. Journal of Biological Chemistry. 282, 29987-29997 (2007) 

  2. Tanaka T, De Luca LM. Therapeutic Potential of “Rexinoids” in Cancer prevention and Treatment. Cancer Research. 69: 4945-4947, 2009 

  3. Tanaka T, Mangala LS, Vivas-Mejia PE, Nieves R, Mann AP, Mora E, Han H-D, Shahzad MK, Liu X, Bhavane R, Gu J, Jakhoury F, Chiappini C, Matsuo K, Godin B, Stone RL, Nick AL, Lopez-Berestein G, Sood AK, Ferrari M. Sustained siRNA Delivery by Mesoporous Silicon Particles. Cancer Research. 70(9):3687-96, 2010

  4. Mann AP, Bhavane RC, Somasunderam A, Montalvo-Ortiz BL, Ghaghada KB, Volk D, Nieves R, Suh KS, Ferrari M, Annapragada A, Gorenstein DG, Tanaka T, Thioaptamer Conjugated Liposomes for Tumor Vasculature Targeting. Oncotarget. 2(4): 298-304, 2011

  5. Mann AP, Tanaka T, Somasunderam A, Liu X, Gorenstein DG, Ferrari M. E-Selectin-targeted porous silicon particle for nanoparticle delivery to the bone marrow. Advanced Material. 23;36, H278-282, 2011

  6. Kang S-A, Hasan N, Mann, AP, Zheng W, Zhao L, Morris L, Zhu W, Zhao D, Suh SK, Dooley WC, Volk D, Gorenstein DG, Cristofanilli M, Rui H, Tanaka T. Blocking the adhesion cascade at the pre-metastatic niche for prevention of breast cancer metastasis. Molecular Therapy. 2015 Mar 27. doi: 10.1038/mt.2015.45. PMID: 25815697

  7. Kang S-A, Hasan N, Mann AP, Zheng W, Zhao L, Morris L, Zhu W, Zhao D, Suh SK, Volk D, Gorenstein DG, Rui H, Tanaka T. Safety evaluation of intravenously administered mono-thioated aptamer against E-selectin in mice. Toxicology and Applied Pharmacology. I 15;287(1):86-92. doi: 10.1016/j.taap.2015.05.011, 2015.

  8. Kang SA, Blache CA, Bajana S, Hasan N, Kamal M, Morita Y, Gupta V, Tsolmon B, Suh KS, Gorenstein DG, RazaqW, Rui H, Tanaka T. The effect of soluble E-selectin on tumor progression and metastasis. BMC Cancer. 2016 May 24;16:331. doi: 10.1186/s12885-016-2366-2.

  9. Lingegowda S. Mangala, Hongyu Wang, Dahai Jiang, Sherry Y. Wu, Anoma Somasunderam, David E. Volk, Ganesh L. R. Lokesh, Xin Li, Sunila Pradeep, Xianbin Yang, Monika Haemmerle, Cristian Rodriguez-Aguayo, Archana S Nagaraja, Rajesha Rupaimoole, Emine Bayraktar, Recep Bayraktar, Li Li, Takemi Tanaka, Wei Hu, Cristina Ivan, Kshipra M Gharpure, Michael H. McGuire, Varatharasa Thiviyanathan, Xinna Zhang, Sourindra N. Maiti, Nataliya Bulayeva, Hyun-Jin Choi, Piotr L. Dorniak, Laurence J.N. Cooper, Kevin P. Rosenblatt, Gabriel Lopez-Berestein, David G. Gorenstein, Anil K. Sood. Improving vascular maturation using non-coding RNAs increases anti-tumor effect of chemotherapy. JCI Insight 2016 Oct 20; 1:17, e87754. doi:10.1172/jci.insight.87754. 2016

  10. Yoshi Morita, Mohamed Kamal, Shin-Ae Kang, Roy Zhang, Ganesh L. R. Lokesh, Varatharasa Thiviyanathan, Nafis Hasan, Sukyung Woo, Daniel Zhao, Macall Leslie, Stephen Suh, Wajeeha Razaq, Hallgeir Rui, David G. Gorenstein, David E. Volk, and Takemi Tanaka, E-selectin Targeting PEGylated-thioaptamer Prevents Breast Cancer Metastases, Molecular Therapy, 13;5(12):e399. doi: 10.1038/mtna.2016.103, 2016



Adjunct Faculty

Prabir K. Chakraborty, PhD

Prabir K. Chakraborty, PhD

Assistant Professor (Research)

Daniel J. Cowden, MD, FCAP, CPHIMS

Daniel J. Cowden, MD, FCAP, CPHIMS

Clinical Associate Professor

Charles Esmon, PhD

Charles Esmon, PhD

Lloyd Noble Chair, Cardiovascular Research

Member & Head, Cardiovascular Biology Research at OMRF

Adjunct Professor, Pathology

Adjunct Professor, Biochemistry

Investigator at Howard Hughes Medical Institute

David M Lewis, DDS

David M. Lewis, DDS

Associate Professor
Department of Oral and Maxillofacial Pathology

Adjunct Associate Professor
Department of Pathology

Charles A. Montgomery, DVM, DACVP, DACLAM

Charles A. Montgomery, DVM, DACVP, DACLAM

Adjunct Professor
Department of Pathology
Division of Comparative Medicine

Kathy L. Moser, PhD

Kathy L. Moser, PhD

Associate Member, Arthritis & Immunology Program
OMRF

Adjunct Faculty, Pathology

Aravindan Natarajan

Aravindan Natarajan, MS., MPhil., PhD., CCA.

Associate Professor, Department of Radiation Oncology,
Associate Professor (Adjunct), Department of Anesthesiology,
Associate Professor (Adjunct), Department of Pathology
Course Director, Radiation Biology for Radiation Oncology Residents
Graduate Faculty, College of Medicine
Member, Cancer Biology Program

Amr H. Sawalha, MD

Amr H. Sawalha, MD

Assistant Member
Arthritis and Immunology Research Program

Assistant Professor of Medicine 
Department of Medicine

Staff Physician 
Veteran Affairs Medical Center
Oklahoma City

Adjunct Faculty
Department of Pathology