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Faculty and Staff

Faculty

Wei-Qun Ding, PhD
Pathology

Wei-Qun Ding, PhD

Associate Professor of Experimental Pathology 
Research/Molecular Oncology


Biomedical Sciences Center
940 Stanton L. Young Blvd
RM 401A
Oklahoma City, OK 73104-5020

405-271-1605

weiqun-ding@ouhsc.edu


Academic Section(s):

Pathology


Education:

  • Lund University
    Department of Medical Neurochemistry
    Lund, Sweden
    PhD (1998)
  • Center for Basic Research in Digestive Diseases
    Mayo Clinic and Foundation
    Postdoctoral research fellow (2002)


Clinical/Research Interests:

This laboratory investigates cellular mechanisms of exosome microRNA signaling in cancer cells and their potential implications in cancer diagnosis and therapy. We are also interested in developing combination therapies using docosahexaenoic acid (a long chain n-3 polyunsaturated fatty acid), and other anticancer drugs. A combination of cellular, molecular, and biochemical approaches are applied to address critical questions using experimental model systems and patient specimens.


Select Publications:

  1. Zou S, Yang J, Guo J, Su Y, He C, Wu J, Yu L, Ding WQ, Zhou J. RAD18 promotes the migration and invasion of esophageal squamous cell cancer via the JNK-MMPs pathway. Cancer Lett. 2018 Mar 28;417:65-74. PMID: 29306013.

  2. Hannafon BN, Ding WQ. miRNAs as Biomarkers for Predicting the Progression of Ductal Carcinoma in Situ. Am J Pathol. 2018 Mar;188(3):542-549. PMID: 29246496.

  3. Xue J, Zhu W, Song J, Jiao Y, Luo J, Yu C, Zhou J, Wu J, Chen M, Ding WQ, Cao J, Zhang S. Activation of PPARα by clofibrate sensitizes pancreatic cancer cells to radiation through the Wnt/Β-catenin pathway. Oncogene. 2018 Feb 15;37(7):953-962. PMID: 29059162.

  4. Xu YF, Hannafon BN, Zhao YD, Postier RG, Ding WQ. Plasma exosome miR-196a and miR-1246 are potential indicators of localized pancreatic cancer. Oncotarget. 2017 Aug 18;8(44):77028-77040. PMID: 29100367.

  5. Hannafon BN, Trigoso YD, Calloway CL, Zhao YD, Lum DH, Welm AL, Zhao ZJ, Blick KE, Dooley WC, Ding WQ. Plasma exosome microRNAs are indicative of breast cancer. Breast Cancer Res. 2016 Sep 8;18(1):90. PMID: 27608715.

  6. Jiao Y, Hannafon BN, Ding WQ. Disulfiram's Anticancer Activity: Evidence and Mechanisms. Anticancer Agents Med Chem. 2016;16(11):1378-1384. PMID: 27141876.

  7. Hannafon BN, Carpenter KJ, Berry WL, Janknecht R, Dooley WC, Ding WQ. Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA). Mol Cancer. 2015 Jul 16;14:133. PMID: 26178901.

  8. Zhang S, Xue J, Zheng J, Wang S, Zhou J, Jiao Y, Geng Y, Wu J, Hannafon BN, Ding WQ. The superoxide dismutase 1 3'UTR maintains high expression of the SOD1 gene in cancer cells: The involvement of the RNA-binding protein AUF-1. Free Radic Biol Med. 2015 Aug;85:33-44. PMID: 25908445.

  9. Zhang S, Wang W, Gu Q, Xue J, Cao H, Tang Y, Xu X, Cao J, Zhou J, Wu J, Ding WQ. Protein and miRNA profiling of radiation-induced skin injury in rats: the protective role of peroxiredoxin-6 against ionizing radiation. Free Radic Biol Med. 2014 Apr;69:96-107. PMID: 24447893.

  10. Wang S, Hannafon BN, Wolf RF, Zhou J, Avery JE, Wu J, Lind SE, Ding WQ. Characterization of docosahexaenoic acid (DHA)-induced heme oxygenase-1 (HO-1) expression in human cancer cells: the importance of enhanced BTB and CNC homology 1 (Bach1) degradation. J Nutr Biochem. 2014 May;25(5):515-25. PMID: 24613086.



Adjunct Faculty

Prabir K. Chakraborty, PhD

Prabir K. Chakraborty, PhD

Assistant Professor (Research)

Daniel J. Cowden, MD, FCAP, CPHIMS

Daniel J. Cowden, MD, FCAP, CPHIMS

Clinical Associate Professor

Charles Esmon, PhD

Charles Esmon, PhD

Lloyd Noble Chair, Cardiovascular Research

Member & Head, Cardiovascular Biology Research at OMRF

Adjunct Professor, Pathology

Adjunct Professor, Biochemistry

Investigator at Howard Hughes Medical Institute

David M Lewis, DDS

David M. Lewis, DDS

Associate Professor
Department of Oral and Maxillofacial Pathology

Adjunct Associate Professor
Department of Pathology

Yuechueng Liu, PhD

Yuechueng Liu, PhD

Associate Professor of Pathology

Jeffrey McBride, MD, PhD

Jeffrey McBride, MD, PhD

Assistant Professor

Director of Dermatopathology

Adjunct Faculty - Pathology

Charles A. Montgomery, DVM, DACVP, DACLAM

Charles A. Montgomery, DVM, DACVP, DACLAM

Adjunct Professor
Department of Pathology
Division of Comparative Medicine

Kathy L. Moser, PhD

Kathy L. Moser, PhD

Associate Member, Arthritis & Immunology Program
OMRF

Adjunct Faculty, Pathology

Aravindan Natarajan

Aravindan Natarajan, MS., MPhil., PhD., CCA.

Associate Professor, Department of Radiation Oncology,
Associate Professor (Adjunct), Department of Anesthesiology,
Associate Professor (Adjunct), Department of Pathology
Course Director, Radiation Biology for Radiation Oncology Residents
Graduate Faculty, College of Medicine
Member, Cancer Biology Program

Amr H. Sawalha, MD

Amr H. Sawalha, MD

Assistant Member
Arthritis and Immunology Research Program

Assistant Professor of Medicine 
Department of Medicine

Staff Physician 
Veteran Affairs Medical Center
Oklahoma City

Adjunct Faculty
Department of Pathology