Faculty

The University of Oklahoma Health Sciences Center
975 NE 10th ST, BRC 1409A
Oklahoma City, OK 73104

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Education:

• BS - Chemistry, University of Burdwan, India (1992)
• MS - Chemistry, University of Burdwan, India (1994)
• PhD - Chemistry, University of Poona, India (2000)

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Fellowship:

• Junior Research Fellow, Council of Scientific Industrial Research, India (1994-1996)
• Senior Research Fellow, Council of Scientific Industrial Research, India (1997-2000)
• Postdoctoral Fellow, Department of Chemistry, Texas Christian University, Fort Worth, TX (2001-2003)
• Research Fellow, Harvard Medical School/Children’s Hospital, Boston, MA (2003-2004)
• Senior Research Fellow, Mayo Clinic, Rochester, MN (2004-2005)

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Clinical/Research Interests:

• Reprogramming tumor microenvironment by nanoparticles
• Anti-Angiogenic property of inorganic nanoparticles
• Metabolic enzyme and angiogenesis
• Identification of new molecular targets using nanotechnology
• Nanoendocytosis
• Understanding cellular processes using engineered nanoparticles
• Metabolic enzymes in cancer

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Select Publications:

1. Zhang, Y., Elechalawar, C. K, Yang, W., Frickenstein, A. N., Asfa, S., Fung, K., Murphy, B. N., Dwivedi, S. K., Rao, G., Dey, A., Wilhelm, S., Bhattacharya, R., Mukherjee. P.Disabling partners in crime: gold nanoparticles disrupt multicellular communications within the tumor microenvironment to inhibit ovarian tumor aggressiveness. (2022). Materials Today Feb 22, 2022 in press. https://doi.org/10.1016/j.mattod.2022.01.025
2. Hybrid nanosystems for biomedical applications. Joshua Seaberg, Hossen Montazerian, Md Nazir Hossen, Resham Bhattacharya, Ali Khademhosseini, Priyabrata Mukherjee. (2021) ACS Nano, 15, 2099-2142
3. Switching the intracellular pathway and enhancing the therapeutic efficacy of small interfering RNA by Auroliposome. Md. Nazir Hossen^1,2, Lin Wang³, Harisha. R. Chinthalapally^1,2, Joe. D. Robertson⁴, Kar-Ming Fung^1,2, Stefan Wilhelm⁵, Magdalena Bieniasz³, Resham Bhattacharya⁶ and Priyabrata Mukherjee^1,2* . (2020) Science Advances, 6(30), eaba5379. PMID: 32743073. DOI: 10.1126/sciadv.aba5379. 
4. Dey, A.⁺, Prabhudesai, S.⁺, Zhang, Y., Rao, G., Thirugnanam, K., Hossen, M. N., Dwivedi, S. K. D., Ramchandran, R., Mukherjee, P., Bhattacharya, R. (2020). Cystathione β-synthase regulates HIF-1α stability through persulfidation of PHD2. Science Advances. 2020 Jul 3;6(27):eaaz8534. doi: 10.1126/sciadv.aaz8534.
5. Rao G, Dwivedi SKD, Zhang Y, Dey A, Shameer K, Karthik R, Srikantan S, Hossen MN, Wren JD, Madesh M, Dudley JT, Bhattacharya R, Mukherjee P. MicroRNA-195 controls MICU1 expression and tumor growth in ovarian cancer. EMBO Rep. 2020 Oct 5;21(10):e48483. doi: 10.15252/embr.201948483 
6. Xiong, X., Rao, G., Roy, R. V., Zhang, Y., Means, N., Dey, A., Tsaliki, M., Saha, S., Bhattacharyya, S., Dhar Dwivedi, S. K., Rao, C. V., McCormick, D. J., Dhanasekaran, N., Ding, K., Gillies, E. M., Zhang, M., Yang, D., Bhattacharya, R., Mukherjee, P. (2020). Ubiquitin-binding associated protein 2 regulates KRAS activation and macropinocytosis in pancreatic cancer. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. PMID: 32692445. DOI: 10.1096/fj.201902826RR 
7. Hossen, M. N., Rao, G., Dey, A., Robertson, J. D., Bhattacharya, R., Mukherjee, P. (2019). Gold Nanoparticle Transforms Activated Cancer-Associated Fibroblasts to Quiescence. ACS applied  materials & interfaces, 11(29), 26060-26068. PMID: 31117437. DOI: 10.1021/acsami.9b03313
8. Chakraborty, P. K., Mustafi, S. B., Xiong, X., Dwivedi SKD, Nesin, V., Saha, S., Zhang, M., Dhanasekaran, N., Jayaraman, M., Mannel, R. S., Moore, K., McMeekin, S., Yang, D., Zuna, R. E., Ding, K., Tsiokas, L., Bhattacharya, R., Mukherjee, P. (2017). MICU1 drives glycolysis and chemoresistance in ovarian cancer. Nature communications, 8, 14634. PMID: 28530221. DOI: 10.1038/ncomms14634
9. Arvizo, R. R., Saha, S., Wang, E., Robertson, J. D., Bhattacharya, R., Mukherjee, P. (2013). Inhibition of tumor growth and metastasis by a self-therapeutic nanoparticle. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 110(17), 6700-5. PMID: 23569259. DOI: 10.1073/pnas.1214547110
10. Bhattacharyya, S., Bhattacharya, R., Curley, S., McNiven, M. A., Mukherjee, P. (2010). Nanoconjugation modulates the trafficking and mechanism of antibody induced receptor endocytosis. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 107(33), 14541-6. PMID: 20679244. DOI: 10.1073/pnas.1006507107