Faculty

975 NE 10th Street
BRC-W, 1415
Oklahoma City, OK 73104

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Education:

• PhD - University of Shizuoka, Shizuoka, Japan (1996-1999)

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Fellowship:

• Postdoctoral Fellow, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda (1999-2004)
• Research Fellow, Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, National Institutes of Health, Bethesda (2004-2006)

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Memberships:

• American Association of Cancer Research
• Japanese Biochemical Society
• Japanese Society of Cancer Research

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Clinical/Research Interests:

• Breast cancer metastasis and metastasis prevention
• Anti-migration therapy for breast cancer treatment
• Tumor inflammation
• Identification of prognostic biomarker
• Type II diabetes and immunity in cancer
• Cancer health disparities

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Select Publications:

1. Tanaka T, Suh KS, Lo AM, De Luca LM. p21^WAF1/CIP1 is a common transcriptional target of retinoid receptors:pleiotropic regulatory mechanism through RAR/RXR heterodimer and RXR/RXR homodimer. Journal of Biological Chemistry. 282, 29987-29997 (2007) 
2. Tanaka T, De Luca LM. Therapeutic Potential of “Rexinoids” in Cancer prevention and Treatment. Cancer Research. 69: 4945-4947, 2009 
3. Tanaka T, Mangala LS, Vivas-Mejia PE, Nieves R, Mann AP, Mora E, Han H-D, Shahzad MK, Liu X, Bhavane R, Gu J, Jakhoury F, Chiappini C, Matsuo K, Godin B, Stone RL, Nick AL, Lopez-Berestein G, Sood AK, Ferrari M. Sustained siRNA Delivery by Mesoporous Silicon Particles. Cancer Research. 70(9):3687-96, 2010
4. Mann AP, Bhavane RC, Somasunderam A, Montalvo-Ortiz BL, Ghaghada KB, Volk D, Nieves R, Suh KS, Ferrari M, Annapragada A, Gorenstein DG, Tanaka T, Thioaptamer Conjugated Liposomes for Tumor Vasculature Targeting. Oncotarget. 2(4): 298-304, 2011
5. Mann AP, Tanaka T, Somasunderam A, Liu X, Gorenstein DG, Ferrari M. E-Selectin-targeted porous silicon particle for nanoparticle delivery to the bone marrow. Advanced Material. 23;36, H278-282, 2011
6. Kang S-A, Hasan N, Mann, AP, Zheng W, Zhao L, Morris L, Zhu W, Zhao D, Suh SK, Dooley WC, Volk D, Gorenstein DG, Cristofanilli M, Rui H, Tanaka T. Blocking the adhesion cascade at the pre-metastatic niche for prevention of breast cancer metastasis. Molecular Therapy. 2015 Mar 27. doi: 10.1038/mt.2015.45. PMID: 25815697
7. Kang S-A, Hasan N, Mann AP, Zheng W, Zhao L, Morris L, Zhu W, Zhao D, Suh SK, Volk D, Gorenstein DG, Rui H, Tanaka T. Safety evaluation of intravenously administered mono-thioated aptamer against E-selectin in mice. Toxicology and Applied Pharmacology. I 15;287(1):86-92. doi: 10.1016/j.taap.2015.05.011, 2015.
8. Kang SA, Blache CA, Bajana S, Hasan N, Kamal M, Morita Y, Gupta V, Tsolmon B, Suh KS, Gorenstein DG, RazaqW, Rui H, Tanaka T. The effect of soluble E-selectin on tumor progression and metastasis. BMC Cancer. 2016 May 24;16:331. doi: 10.1186/s12885-016-2366-2.
9. Lingegowda S. Mangala, Hongyu Wang, Dahai Jiang, Sherry Y. Wu, Anoma Somasunderam, David E. Volk, Ganesh L. R. Lokesh, Xin Li, Sunila Pradeep, Xianbin Yang, Monika Haemmerle, Cristian Rodriguez-Aguayo, Archana S Nagaraja, Rajesha Rupaimoole, Emine Bayraktar, Recep Bayraktar, Li Li, Takemi Tanaka, Wei Hu, Cristina Ivan, Kshipra M Gharpure, Michael H. McGuire, Varatharasa Thiviyanathan, Xinna Zhang, Sourindra N. Maiti, Nataliya Bulayeva, Hyun-Jin Choi, Piotr L. Dorniak, Laurence J.N. Cooper, Kevin P. Rosenblatt, Gabriel Lopez-Berestein, David G. Gorenstein, Anil K. Sood. Improving vascular maturation using non-coding RNAs increases anti-tumor effect of chemotherapy. JCI Insight 2016 Oct 20; 1:17, e87754. doi:10.1172/jci.insight.87754. 2016
10. Yoshi Morita, Mohamed Kamal, Shin-Ae Kang, Roy Zhang, Ganesh L. R. Lokesh, Varatharasa Thiviyanathan, Nafis Hasan, Sukyung Woo, Daniel Zhao, Macall Leslie, Stephen Suh, Wajeeha Razaq, Hallgeir Rui, David G. Gorenstein, David E. Volk, and Takemi Tanaka, E-selectin Targeting PEGylated-thioaptamer Prevents Breast Cancer Metastases, Molecular Therapy, 13;5(12):e399. doi: 10.1038/mtna.2016.103, 2016