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Neurosurgery ​Research Faculty & Staff

Julio Morales, Ph.D.
Neurosurgery

Julio Morales, Ph.D.

Assistant Professor

405-271-2216

julio-morales@ouhsc.edu

Education:

University of Texas, Austin, TX     1993-1998

B.S. Molecular Biology, June 1998

University of Texas Health Science Center, Houston, TX     2001-2005

Ph.D. Biochemistry, December 2005

 

Board Certification(s):

  

Clinical/Research Interests:

Research Experiences:

University of Texas, Austin, TX     1996-1998

Undergraduate research assistant, Dr. George B. Kitto

University of Texas Health Science Center, Houston TX     1998-2001

Research Assistant, Dr. Phillip B. Carpenter

University of Texas Health Science Center, Houston TX     2001-2006

Graduate Student, Dr. Phillip B. Carpenter

University of Texas Southwestern Medical Center, Dallas, TX     2006-2012

Postdoctoral Research Fellow, Dr. David A. Boothman

University of Texas Southwestern Medical Center, Dallas, TX     2012-2014

Assistant Instructor

University of Texas Southwestern Medical Center, Dallas, TX     2014-2015

Research Associate

University of Oklahoma Health Science Center     2015-present

Assistant Professor (term) 

Select Publications:

  1. Dang TT, Morales JC. Loss of CENP-I Impairs Homologous Recombination and Sensitizes Cells to PARP1 Inhibition. Cancers (Basel). 2021 Jun 26;13(13). doi: 10.3390/cancers13133202. PubMed PMID: 34206916; PubMed Central PMCID: PMC8267748.
  1. Dang TT, McIntosh AT, Morales JC, Pearson GW. miR614 Expression Enhances Breast Cancer Cell Motility. Int J Mol Sci. 2020 Dec 24;22(1). doi: 10.3390/ijms22010112. PubMed PMID: 33374314; PubMed Central PMCID: PMC7801944.
  1. Patidar PL, Viera T, Morales JC, Singh N, Motea EA, Khandelwal M, Fattah FJ. XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition. Sci Rep. 2020 Aug 28;10(1):14253. doi: 10.1038/s41598-020-71203-7. PubMed PMID: 32859985; PubMed Central PMCID: PMC7455564.
  1. Dang TT, Morales JC. XRN2 Links RNA:DNA Hybrid Resolution to Double Strand Break Repair Pathway Choice. Cancers (Basel). 2020 Jul 7;12(7). doi: 10.3390/cancers12071821. PubMed PMID: 32645903; PubMed Central PMCID: PMC7408924.
  1. Dang TT, Morales JC. Involvement of POLA2 in Double Strand Break Repair and Genotoxic Stress. Int J Mol Sci. 2020 Jun 15;21(12). doi: 10.3390/ijms21124245. PubMed PMID: 32549188; PubMed Central PMCID: PMC7352189.
  1. Motea EA, Fattah FJ, Xiao L, Girard L, Rommel A, Morales JC, Patidar P, Zhou Y, Porter A, Xie Y, Minna JD, Boothman DA. Kub5-Hera RPRD1B Deficiency Promotes "BRCAness" and Vulnerability to PARP Inhibition in BRCA-proficient Breast Cancers. Clin Cancer Res. 2018 Dec 15;24(24):6459-6470. doi: 10.1158/1078-0432.CCR-17-1118. Epub 2018 Aug 14. PubMed PMID: 30108102; PubMed Central PMCID: PMC6295248.
  1. Tang KJ, Constanzo JD, Venkateswaran N, Melegari M, Ilcheva M, Morales JC, Skoulidis F, Heymach JV, Boothman DA, Scaglioni PP. Focal Adhesion Kinase Regulates the DNA Damage Response and Its Inhibition Radiosensitizes Mutant KRAS Lung Cancer. Clin Cancer Res. 2016 Dec 1;22(23):5851-5863. doi: 10.1158/1078-0432.CCR-15-2603. Epub 2016 May 24. PubMed PMID: 27220963; PubMed Central PMCID: PMC5122471.
  1. Morales JC, Richard P, Patidar PL, Motea EA, Dang TT, Manley JL, Boothman DA. XRN2 Links Transcription Termination to DNA Damage and Replication Stress. PLoS Genet. 2016 Jul;12(7):e1006107. doi: 10.1371/journal.pgen.1006107. eCollection 2016 Jul. PubMed PMID: 27437695; PubMed Central PMCID: PMC4954731.
  1. Patidar PL, Motea EA, Fattah FJ, Zhou Y, Morales JC, Xie Y, Garner HR, Boothman DA. The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair. Nucleic Acids Res. 2016 Feb 29;44(4):1718-31. doi: 10.1093/nar/gkv1492. Epub 2016 Jan 26. PubMed PMID: 26819409; PubMed Central PMCID: PMC4770225.
  1. Cao L, Li LS, Spruell C, Xiao L, Chakrabarti G, Bey EA, Reinicke KE, Srougi MC, Moore Z, Dong Y, Vo P, Kabbani W, Yang CR, Wang X, Fattah F, Morales JC, Motea EA, Bornmann WG, Yordy JS, Boothman DA. Tumor-selective, futile redox cycle-induced bystander effects elicited by NQO1 bioactivatable radiosensitizing drugs in triple-negative breast cancers. Antioxid Redox Signal. 2014 Jul 10;21(2):237-50. doi: 10.1089/ars.2013.5462. Epub 2014 Apr 3. PubMed PMID: 24512128; PubMed Central PMCID: PMC4060774.
  1. Morales JC, Richard P, Rommel A, Fattah FJ, Motea EA, Patidar PL, Xiao L, Leskov K, Wu SY, Hittelman WN, Chiang CM, Manley JL, Boothman DA. Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair. Nucleic Acids Res. 2014 Apr;42(8):4996-5006. doi: 10.1093/nar/gku160. Epub 2014 Mar 3. PubMed PMID: 24589584; PubMed Central PMCID: PMC4005673.
  1. Morales J, Li L, Fattah FJ, Dong Y, Bey EA, Patel M, Gao J, Boothman DA. Review of poly (ADP-ribose) polymerase (PARP) mechanisms of action and rationale for targeting in cancer and other diseases. Crit Rev Eukaryot Gene Expr. 2014;24(1):15-28. doi: 10.1615/critreveukaryotgeneexpr.2013006875. Review. PubMed PMID: 24579667; PubMed Central PMCID: PMC4806654.
  2. Goetz EM, Shankar B, Zou Y, Morales JC, Luo X, Araki S, Bachoo R, Mayo LD, Boothman DA. ATM-dependent IGF-1 induction regulates secretory clusterin expression after DNA damage and in genetic instability. Oncogene. 2011 Sep 1;30(35):3745-54. doi: 10.1038/onc.2011.92. Epub 2011 Apr 4. PubMed PMID: 21460853; PubMed Central PMCID: PMC4807730.
  3. Li LS, Morales JC, Veigl M, Sedwick D, Greer S, Meyers M, Wagner M, Fishel R, Boothman DA. DNA mismatch repair (MMR)-dependent 5-fluorouracil cytotoxicity and the potential for new therapeutic targets. Br J Pharmacol. 2009 Oct;158(3):679-92. doi: 10.1111/j.1476-5381.2009.00423.x. Epub 2009 Sep 23. Review. PubMed PMID: 19775280; PubMed Central PMCID: PMC2765589.
  1. Wagner MW, Li LS, Morales JC, Galindo CL, Garner HR, Bornmann WG, Boothman DA. Role of c-Abl kinase in DNA mismatch repair-dependent G2 cell cycle checkpoint arrest responses. J Biol Chem. 2008 Aug 1;283(31):21382-93. doi: 10.1074/jbc.M709953200. Epub 2008 May 14. PubMed PMID: 18480061; PubMed Central PMCID: PMC2490779.
  1. Li LS, Morales JC, Hwang A, Wagner MW, Boothman DA. DNA mismatch repair-dependent activation of c-Abl/p73alpha/GADD45alpha-mediated apoptosis. J Biol Chem. 2008 Aug 1;283(31):21394-403. doi: 10.1074/jbc.M709954200. Epub 2008 May 14. PubMed PMID: 18480060; PubMed Central PMCID: PMC2490771.
  1. Suzuki M, Goetz EC, Veneziano G, Shankar B, Zou Y, Morales JC, Boothman DA. Secretory clusterin (sCLU) is a hallmark sensor of DNA damage, cell stress, and cellular senescence: Evidences for similar regulation of sCLU expression after celluar stress and replicative senescence. International congress series. 2007 February; 1299:150-157. doi: 10.1016/j.ics.2006.10.017.
  1. Morales JC, Franco S, Murphy MM, Bassing CH, Mills KD, Adams MM, Walsh NC, Manis JP, Rassidakis GZ, Alt FW, Carpenter PB. 53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis. Proc Natl Acad Sci U S A. 2006 Feb 28;103(9):3310-5. doi: 10.1073/pnas.0511259103. Epub 2006 Feb 21. PubMed PMID: 16492765; PubMed Central PMCID: PMC1413919.
  1. Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW. H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell. 2006 Jan 20;21(2):201-14. doi: 10.1016/j.molcel.2006.01.005. PubMed PMID: 16427010.
  1. Adams MM, Wang B, Xia Z, Morales JC, Lu X, Donehower LA, Bochar DA, Elledge SJ, Carpenter PB. 53BP1 oligomerization is independent of its methylation by PRMT1. Cell Cycle. 2005 Dec;4(12):1854-61. doi: 10.4161/cc.4.12.2282. Epub 2005 Dec 28. PubMed PMID: 16294047.
  1. Morales JC, Carpenter PB. Breaking in a new function for casein kinase 2. Sci Aging Knowledge Environ. 2004 Jun 2;2004(22):pe24. doi: 10.1126/sageke.2004.22.pe24. Review. PubMed PMID: 15175499.
  1. Manis JP, Morales JC, Xia Z, Kutok JL, Alt FW, Carpenter PB. 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat Immunol. 2004 May;5(5):481-7. doi: 10.1038/ni1067. Epub 2004 Apr 11. PubMed PMID: 15077110.
  1. Morales JC, Xia Z, Lu T, Aldrich MB, Wang B, Rosales C, Kellems RE, Hittelman WN, Elledge SJ, Carpenter PB. Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability. J Biol Chem. 2003 Apr 25;278(17):14971-7. doi: 10.1074/jbc.M212484200. Epub 2003 Feb 10. PubMed PMID: 12578828.
  1. Fernandez-Capetillo O, Chen HT, Celeste A, Ward I, Romanienko PJ, Morales JC, Naka K, Xia Z, Camerini-Otero RD, Motoyama N, Carpenter PB, Bonner WM, Chen J, Nussenzweig A. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol. 2002 Dec;4(12):993-7. doi: 10.1038/ncb884. PubMed PMID: 12447390.
  1. Xia Z, Morales JC, Dunphy WG, Carpenter PB. Negative cell cycle regulation and DNA damage-inducible phosphorylation of the BRCT protein 53BP1. J Biol Chem. 2001 Jan 26;276(4):2708-18. doi: 10.1074/jbc.M007665200. Epub 2000 Oct 20. PubMed PMID: 11042216.