Academic Section(s):
Pathology
Education:
BS - Universidad de Ciencias, Granada, Spain (1982-1987)
PhD - Centro de Investigaciones Biológicas, Universidad Autónoma de Madrid, Madrid, Spain (1988-1992)
Clinical/Research Interests:
The research in Dr. Ruiz-Echevarria's laboratory is driven to provide insights into the development and progression of prostate cancer—a process which is inextricably linked to androgen receptor signaling, with the ultimate goal of developing more effective diagnostic, prognostic and therapeutic strategies for prostate cancer. Focusing on the following areas:
- Androgen receptor and co-regulators in prostate cancer progression
- Androgen signaling and therapeutic resistance
- Tumor suppressors in Prostate cancer
- Understanding the link between development and cancer
Select Publications:
- Corbin JM, Georgescu C, Wren JD, Xu C, Asch AS, Ruiz-Echevarría MJ. Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells. bioRxiv: https://www.biorxiv.org/content/10.1101/2020.07.17.209379v1.full.
- Georgescu, C., Corbin, J.M., Thivibilliers, S., Webb, Z.D., Zhao, Y.D., Koster, J. Fung, K.M., Asch, A.S., Wren, J.D., Ruiz-Echevarría M.J. A TMEFF2-regulated cell cycle derived gene signature is prognostic of recurrence risk in prostate cancer. BMC Cancer (2019) 19:423. PMCID: PMC6503380.
- Corbin JM., Overcash RF., Wren JD., Coburn A., Tipton GJ., Ezzell JA., McNaughton KK., Fung KM., Kosanke SD. and Ruiz-Echevarría MJ. Analysis of TMEFF2 allografts and transgenic mouse models reveals roles in prostate development and cancer. The Prostate (2016) 76:97-113. PMCID: PMC4722803
- Chen X, Corbin JM, Tipton GJ, Yang LV, Asch AS, Ruiz-Echevarría MJ. The TMEFF2 tumor suppressor modulates integrin expression, RhoA activation and migration of prostate cancer cells. Biochim Biophys Acta. 2014 Jun;1843(6):1216-24. doi: 10.1016/j.bbamcr.2014.03.005. Epub 2014 Mar 13. PubMed PMID: 24632071; PubMed Central PMCID: PMC4021708.
- Green T, Chen X, Ryan S, Asch AS, Ruiz-Echevarría MJ. TMEFF2 and SARDH cooperate to modulate one-carbon metabolism and invasion of prostate cancer cells. Prostate. 2013 Oct;73(14):1561-75. doi: 10.1002/pros.22706. Epub 2013 Jul 3. PubMed PMID: 23824605; PubMed Central PMCID: PMC3878307.
- Overcash RF, Chappell VA, Green T, Geyer CB, Asch AS, Ruiz-Echevarría MJ. Androgen signaling promotes translation of TMEFF2 in prostate cancer cells via phosphorylation of the α subunit of the translation initiation factor 2. PLoS One. 2013;8(2):e55257. doi: 10.1371/journal.pone.0055257. Epub 2013 Feb 6. PubMed PMID: 23405127; PubMed Central PMCID: PMC3566213.
- Chen X, Ruiz-Echevarría MJ. TMEFF2 modulates the AKT and ERK signaling pathways. Int J Biochem Mol Biol. 2013;4(2):83-94. Print 2013. PubMed PMID: 23936739; PubMed Central PMCID: PMC3729255.
- Chen X, Overcash R, Green T, Hoffman D, Asch AS, Ruiz-Echevarría MJ. The tumor suppressor activity of the transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) correlates with its ability to modulate sarcosine levels. J Biol Chem. 2011 May 6;286(18):16091-100. doi: 10.1074/jbc.M110.193805. Epub 2011 Mar 10. PubMed PMID: 21393249; PubMed Central PMCID: PMC3091218.
- Ruiz-Echevarría MJ, Peltz SW. The RNA binding protein Pub1 modulates the stability of transcripts containing upstream open reading frames. Cell. 2000 Jun 23;101(7):741-51. doi: 10.1016/s0092-8674(00)80886-7. PubMed PMID: 10892745.
- Ruiz-Echevarría MJ, Yasenchak JM, Han X, Dinman JD, Peltz SW. The upf3 protein is a component of the surveillance complex that monitors both translation and mRNA turnover and affects viral propagation. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8721-6. doi: 10.1073/pnas.95.15.8721. PubMed PMID: 9671745; PubMed Central PMCID: PMC21143.