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CLINICAL RESEARCH

CARDIOVASCULAR CLINICAL RESEARCH TRIALS

(Open Enrollment Only)

Synaptic Plasticity in the Epicardial Ganglionated Plexi (SNAP-GP)

This study will exIMI_DAPA_HFamine changes in synaptic density of ganglionated plexi (GP) neurons in patients with paroxysmal atrial fibrillation (AF) and persistent AF, compared to those without AF who are undergoing planned, cardiac surgery. In addition, the study will examine the effect of low-level tragus stimulation (LLTS) on the synaptic plasticity of the GP neurons.

Physician:  Stavros Stavrakis, MD, PhD
Coordinator:  Karrie Meeks, 405-271-8001, #1, 37520

The Effect of Different Low-Level Tragus Stimulation Parameters on Autonomic Nervous System Function (open to enrollment)

This study aims to study the effect of different tragus stimulation parameters on heart rate variability in healthy volunteers and patients with atrial fibrillation and/or heart failure.

Physician:  Stavros Stavrakis, MD, PhD
Coordinator:  Karrie Meeks, 405-271-8001, #1, 37520

Transcutaneous (Tragus) Vagal Nerve Stimulation for Post-op Afib (open to enrollment)

The purpose of this study is to determine the value of transcutaneous vagus nerve stimulation in reducing the burden of post-operative atrial fibrillation and days of hospitalization after cardiac surgery.

Physician:  Stavros Stavrakis, MD, PhD
Coordinator:  Karrie Meeks, 405-271-8001, #1, 37520

LLTS in ADHF (Open to enrollment)

Low Level Tragus Stimulation (LLTS) to Modulate Inflammation in Acute Decompensated Heart Failure.

The purpose of this study is to study the effects of non-invasive low-level Tragus Stimulation on inflammation in patients with acute heart failure.

Physician:  Tarun Dasari, MD
Coordinator:  Michael Stout, 271-9060

HRV-HF (Open to enrollment)

The Association Between Autonomic Function Improvement and Heart Failure Treatment Responding: A Cross-Sectional Study

The purpose of this study is to compare the percentage of autonomic improvement in treatment responders and non-responders of heart failure with reduced ejection fraction (HFrEF) patient’s dysfunction.

Physician:  Tarun Dasari, MD
Coordinator:  Michael Stout, 271-9060

The Effect of Low LEVel TrAgus STimulation on the Electrophysiological Substrate of Subjects with Ischemic CardioMyopathy and Heart Failure (ELEVATE)

This study will examine the effect of low-level tragus stimulation (LLTS) on repolarization alternans (RA) in patients with ischemic cardiomyopathy and heart failure. In addition, the study will examine whether this effect is independent of heart rate.

Physician:  Stavros Stavrakis, MD, PhD
Coordinator:  Karrie Meeks, 405-271-8001, #1, 37520

Neuromodulation of Inflammation to Treat Heart Failure with Preserved Ejection Fraction (TIN HF)

This study will examine the effects of LLTS on diastolic dysfunction, exercise capacity and inflammation in patients with HFpEF and determine whether these effects are mediated by suppression of inflammation.

Physician:  Stavros Stavrakis, MD, PhD
Coordinator:   Brittany Karfonta, 405-271-3480

LLTS in Peripheral Arterial Disease (Open to enrollment).

Effect of Low-Level Transcutaneous Vagal Stimulation (TVS) on Endothelial Function, Arterial Stiffness and Biomarkers of Endothelial Function in Patients with Peripheral Arterial Disease.

The purpose of this study is to study the effects of non-invasive low-level Tragus Stimulation on inflammation in patients with Peripheral Arterial Disease.

 Physician:  Tarun Dasari, MD
Coordinator:  Michael Stout, 271-9060

Nerina Sepsis (SEPSIS)

Transcutaneous Vagus Nerve Stimulation to Regulate Inflammation and Autonomic Imbalance in Sepsis:A Randomized Pilot Trial.

Physician:  Zain Asad, MD
Coordinator:  Michael Stout, 271-9060

IMI_DAPA_HF

This study will evaluate the effect of in-hospital initiation of Dapagliflozin on clinical outcomes in patients who have been stabilized during hospitalization for acute heart failure.

Physician:  Tarun Dasari, MD
Coordinator:  Michael Stout, 405-271-9060

SOS_AMI

This study will evaluate the efficacy and safety of self-administered subcutaneous selatogrel for prevention of all-cause death and treatment of acute myocardial infarction in subjects with a recent history of acute myocardial infarction.

Physician:  Usman Baber, MD
Coordinator:  Michael Stout, 405-271-9060

ANT-007

This study will compare the effect of abelacimab relative to apixaban on venous thromboembolism (VTE) recurrence and bleeding in patients with cancer associated VTE (ASTER).

Physician:  Federico Silva, MD
Coordinator:  Aurora Vera, 405-271-9060

DAPA-AF

This study will help us determine the effect of Dapagliflozin on AF burden in patients with atrial fibrillation (AF).

Physician:  Stavros Stavrakis, MD, PhD
Coordinator:  Antwanya Shaw, 405-271-9060

REBIRTH

This study will evaluate the effect of Bromocriptine in myocardial recovery therapy (REBIRTH) for peripartum cardiomyopathy.

Physician:  Tarun Dasari, MD
Coordinator:  Antwanya Shaw, 405-271-9060

Change-AF

We will study the effect of early Dronedarone versus usual care to change and improve outcomes in persons with first-detected atrial fibrillation (CHANGE AFIB).

Physician:  Zain Asad, MD
Coordinator:  Antwanya Shaw, 405-271-9060

R01-BiG tVNS-AF

This study will determine the effects of TVNS on autonomic tone, atrial substrate and neuromodulators in patients with paroxysmal atrial fibrillation.

Physician:  Stavros Stavrakis, MD, PhD
Coordinator:  Natalia Wells-Serrano, 405-271-9060

ERADICATE AF II

This study will evaluate renal artery denervation in addition to catheter ablation to eliminate atrial fibrillation.

Physician:  Sunny Po, MD
Coordinator:  Natalia Wells-Serrano, 405-271-9060

 

COMING SOON!

LIBREXIA-AF

Study to evaluate the efficacy and safety of Milvexian, an oral Factor XIa inhibitor, versus Apixaban in participants with atrial fibrillation.

Physician:  Stavros Stavrakis, MD, PhD
Coordinator:  Natalia Wells-Serrano, 405-271-9060