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Research

Dr. Matthew Walters Lab

The major focus of my research program is to understand the cellular processes that regulate airway epithelial stem/progenitor cell fate decisions during repair and regeneration of the lung. Alterations in the normal ratio of differentiated epithelial cell types (defined as epithelial remodeling) are associated with multiple chronic lung diseases including asthma, cystic fibrosis (CF), idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD). The overarching goal of my research is to identify signaling pathways that regulate differentiation of airway epithelial stem/progenitor cells into specific cell types thus providing novel targets for developing new therapies to treat chronic lung disease.